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82results about How to "Fast drug effect" patented technology

Pesticide suspension concentrate containing pleocidin and preparation method thereof

The invention provides a pesticide suspension concentrate containing pleocidin and a preparation method thereof. The suspension concentrate comprises active ingredients such as pleocidin and abamectin, emamectin benzoate, lambda-cyhalothrin, beta-cypermethrin, chlorfenapyr, chlorfluazuron, diafenthiuron, lufenuron, thiamethoxam or butene-fipronil, as well as dispersing agent, wetting agent, functional aids, other aids and water. The preparation method is as follows: mixing the active ingredients, aids and water to a homogeneous pasty material, and then feeding into a sand mill to obtain a mean grain size of 2-4mu m (4.3) by the sand milling. The suspension concentrate of the invention has a small mean grain size, high suspension rate of the product, stable performance and minimal condensate rate under storage at room temperature within two years. Furthermore, as the suspension rate of the preparation is high and the added functional aids increase spreadability and permeability, the pharmacodynamic action of the product is improved.
Owner:SHENZHEN NOPOSION AGROCHEM

Herbicide-fertilizer for direct-seeding rice field and production method of herbicide-fertilizer

ActiveCN102674973AImprove quality stability performanceReduce pollutionFertilizer mixturesAmmonium sulfateFertilizer
The invention discloses a herbicide-fertilizer for a direct-seeding rice field. The herbicide-fertilizer contains herbicide-fertilizer mixture which is prepared by using bensulfuron-methyl with weeding activity, pretilachlor herbicide and a nitrogen-containing fertilizer, wherein the weight ratio of the bensulfuron-methyl to the pretilachlor is 1:9 and the nitrogen-containing fertilizer consists of urea and ammonium sulfate with weight ratio being 1:2. The invention additionally discloses a production method of the herbicide-fertilizer. Water is used as solvent. A spray-coating method is used for preparing herbicide-fertilizer particle mixture. The process flow is short, the quality is stable and the yield is high. The prepared herbicide-fertilizer is suitable for direct-seeding rice fields, can realize synchronous fertilization and weeding, has the characteristics of high safety, excellent stability and good efficacy, and can achieve the goal of labor saving and time saving.
Owner:广西乐土生物科技有限公司

Preparation method of arginine aspirin and powder and injection preparation thereof

The invention discloses an aspirin arginine and a preparation method of powder for injection thereof, the preparation method is characterized in that: arginine is dissolved in water, aspirin is further added, the arginine fully reacts with the aspirin in the water by stirring at the reaction temperature of 60-80 DEG C, chloroform is added after the reaction, the low temperature preservation, the precipitation and the filtration are carried out, sediment is washed and vacuum dried, an aspirin arginine crude product is obtained, and then the aseptic packaging or the freeze-drying after the redissolution is carried out to obtain the aspirin arginine powder for injection. The method has short reaction time and high production efficiency, and the obtained aspirin arginine powder for injection has stable product quality.
Owner:HAINAN LINGKANG PHARMA CO LTD

Niraparib granules with high utilization efficiency and preparation method thereof

The invention discloses niraparib granules with a high utilization efficiency and a preparation method thereof, and belongs to the technical field of medicine production. The components of the niraparib granules include niraparib, glucose, vitamin C and a carboxylesterase inhibitor. A granule packaging machine adopted in the preparation method comprises a storage bin and a transparent upper discharge pipe, wherein the transparent upper discharge pipe penetrates through the storage bin, the two sides of the upper discharge pipe are provided with an infrared emitter and an infrared receiver respectively, the infrared emitter and the infrared receiver are capable of lifting and lowering, a turntable is arranged below the upper discharge pipe, a curved through hole is formed in the turntable,a retractable stop block with a proximity switch is arranged on one side of the turntable, and a curved groove is formed in the turntable. By adopting the niraparib granules, the amount of niraparib discharged along with excretion can be reduced, and the pharmacodynamic effect of the niraparib can be maintained; valve-related components of the granule packaging machine adopted in the preparation process of the niraparib granules have longer service life, it can be ensured that the amount of the material discharged each time is sufficient, the remaining granules with a remaining amount less than a set value are remained in the upper discharge pipe, and the application is convenient.
Owner:ANHUI HAIKANG PHARMA

Medicinal composition for preventing and treating diabetic complications and preparation method thereof

The invention relates to a medicinal composition for preventing and treating diabetic complications and a preparation method thereof. The medicinal composition comprises the following active ingredients in part by weight: 3 parts of total phenolic acids of root of red-rooted salvia, 0.2 to 1.5 parts of total tanshinones and 1 to 10 parts of total flavonoids of kudzuvine root, and pharmaceuticallyacceptable auxiliary materials or carriers. The preparation method comprises the following steps of: respectively extracting corresponding active ingredients from medicinal materials, namely the rootof red-rooted salvia and the kudzuvine root; and mixing the active ingredients and the pharmaceutically acceptable auxiliary materials or carriers according to the proportion to prepare a corresponding medicinal preparation. Deep studies prove that due to the compatibility of the total tanshinones in the root of red-rooted salvia, the total flavonoids of the kudzuvine root and the total phenolic acids of the root of red-rooted salvia, the medicinal composition has obvious synergistic effect, achieves unexpected obvious effect, enhances the medicinal effect of the composition of the total flavonoids of the kudzuvine root and the total phenolic acids of the root of red-rooted salvia and improves the utilization rate of the medicinal materials.
Owner:SICHUAN ACAD OF CHINESE MEDICINE SCI

Vitamin-D3-contained filling agent for preventing dairy cow mastitis and preparation method of filling agent

The invention provides a vitamin-D3-contained filling agent for preventing dairy cow mastitis and a preparation method of the filling agent. Every 10g of filling agent is prepared from the following materials by weight: 20mg-50mg of vitamin D3, 50mg-250mg of ceftiofur hydrochloride, 0.65g-2g of thickener, 50mg-100mg of antioxidant, and the balance of soybean oil or liquid paraffin. The preparation method of the vitamin-D3-contained filling agent comprises the following steps of: preparing the materials for future use; mixing the vitamin D3 and the ceftiofur hydrochloride, dispersing the obtained mixture by the soybean oil or the liquid paraffin, and ultrasonically stirring the mixture with the soybean oil or the liquid paraffin to uniformly disperse the mixture to obtain active ingredient mixed liquor; heating up residual solvent, and adding the thickener and the antioxidant into the mixture to obtain accessory mixed liquor; pouring the active ingredient mixed liquor into the accessory mixed liquor, uniformly stirring the mixture to obtain the vitamin-D3-contained filling agent for preventing the dairy cow mastitis. The vitamin-D3-contained filling agent is used for preventing and curing the dairy cow mastitis caused by pathogenic bacteria such as staphylococcus aureus, streptococcus, escherichia coli and salmonella.
Owner:QILU ANIMAL HEALTH PROD

Quality control method of four-time treated rhizoma cyperi decoction pieces

ActiveCN104155399AImproved anti-dysmenorrhea pharmacological effectsSimple and easy quality control methodComponent separationFingerprintHplc fingerprint
The invention discloses a quality control method of four-time treated rhizoma cyperi decoction pieces. The quality control method comprises the steps: establishing a four-time treated rhizoma cyperi HPLC fingerprint spectrum, and with an active ingredient alpha-cyperone as a benchmark peak, calculating the content of alpha-cyperone in the benchmark peak; and allowing fingerprint peaks of other main active ingredients to take alpha-cyperone as a reference, calculating the relative contents of the fingerprint peaks of the active ingredients according to alpha-cyperone. The method has operability, can control the relative contents of other unknown main effective ingredients only with the known reference substance alpha-cyperone ingredient content, and is a scientific method achieving control of the quality of the four-time treated rhizoma cyperi decoction pieces. The method is simple, is easy to popularize, reduces the use amount of the reference substance, solves the problems that a market monomeric material reference substance is insufficient and expensive, makes the quality of the four-time treated rhizoma cyperi decoction pieces stable, enhances the pharmacological function, and is conducive to promote rapid development of traditional Chinese medicine industries.
Owner:江西龙开河中药饮片有限公司

Metformin hydrochloride gastric floating tablet and preparation method thereof

The invention relates to a metformin hydrochloride gastric floating tablet. The metformin hydrochloride gastric floating tablet contains metformin hydrochloride, a polymer gel material, a wax material and a foaming material, wherein the polymer gel material is a mixture of water-soluble resin and lactose; the wax material is at least one of octodecyl alcohol and stearic acid; and the foaming material is a mixture of sodium bicarbonate and magnesium stearate. A preparation method comprises wet process pelletization and powder direct tabletting, wherein the wet process pelletization comprises the following steps: A1) preparing the materials; A2) mixing the materials; A3) pelletizing; and A4) tabletting; and the powder direct tabletting comprises the following steps: B1) preparing the materials; B2) mixing the materials; and B3) tabletting. Each metformin hydrochloride gastric floating tablet contains 0.25-0.75g of metformin hydrochloride. The metformin hydrochloride gastric floating tablet disclosed by the invention has the advantages that after the tablets are taken by a patient, hydrophilic gel is hydrated and expanded, a medicament is simultaneously controlled to be released slowly, the onset of action of the medicament is fast, the medicament effect is lasting and the bioavailability of the medicament is high; and the frequency of taking the tablets of the patient can be reduced, the side effects are reduced, and the incidence rate of poor reactions is also reduced.
Owner:CHENGDU HENGRUI PHARMA

A pharmaceutical composition containing an analgesic and fospropofol disodium

The invention discloses a pharmaceutical composition containing a non-narcotic analgesic or a narcotic analgesic and pharmaceutically acceptable salts thereof and fospropofol disodium. The non-narcotic analgesic is nefopam hydrochloride or nefopam. The narcotic analgesic is selected from fentanyl, remifentanil, alfentanil and sufentanil. The pharmaceutical composition can be directly used for clinic comprising anesthesia induction, maintenance of anesthesia, post operation or ICU analgesia, and the like. The pharmaceutical composition has functions of analgesia and sedation. Through addition or synergistic effects of medicines, the pharmaceutical effects are enhanced, the dosage is reduced, untoward effects in pain treatment is prevented and relieved, the number of times of administration by an anesthetist is reduced, and therefore an anesthesia induction process is more convenient and an ideal anesthesia effect can be achieved.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Preparation method of Trichosanthes kirilowii Maxim oral liquid

InactiveCN110898120AGood for treating constipationQuick Fill and SaveThreaded caps applicationDispersion deliveryAngelica Sinensis RootTrichosanthes kirilowii
The invention discloses a preparation method of Trichosanthes kirilowii Maxim oral liquid, comprising the following steps: step 1, weighing raw materials: weighing 19-21 parts of Agastache rugosus, 56-64 parts of Mangnolia officinalis, 19-21 parts of white paeony root, 9-10 parts of delavay soapberry pericarp seed, 9-11 parts of Platycodon grandiflorum, 14-16 parts of apricot kernel, 60-80 parts of Trichosanthes kirilowii Maxim, 9-13 parts of Angelica sinensis, and 19-21 parts of peach kernel. Trichosanthes kirilowii Maxim added in the invention has the effects of moistening lung for removingphlegm, smoothing intestine and relaxing the bowels and is mainly used for cough caused by dryness and phlegm and constipation due to intestinal dryness; Mangnolia officinalis has therapeutical effecton diseases such as dyspepsia and qi stagnation, abdomen distension and constipation, damp retention in middle-jiao and the like; Angelica sinensis has effects of invigorating qi and blood, regulating menstruation and relieving pain, moistening dryness and smoothing intestine; white paeony root has efficacy of warming yang and eliminating dampness, tonifying body deficiency, strengthening spleenand stomach, etc.; and peach kernel has the effect of promoting digestion and removing food retention. By combining the various medicines to achieve the effects of tonifying middle-Jiao and qi, tonifying spleen and promoting circulation, the oral liquid of the invention is used for treating constipation.
Owner:ANHUI ZANJIATIAN ECOLOGICAL AGRI CO LTD

Method for preparing tripterygium wilfordii extract by using triterpenes as main components and pharmaceutical application of tripterygium wilfordii extract

The invention discloses a method for preparing a tripterygium wilfordii extract by using triterpenes as main components and a pharmaceutical application of the triterpenes as main components. The method for preparing the tripterygium wilfordii extract by using triterpenes as main components comprises the following steps: (1) crushing a dried tripterygium wilfordii root medicinal material, screening through a screen of 10-40 meshes, and weighing 150-200g of powder; (2) performing ultrasonic extraction with an extracting solvent, wherein the usage ratio of the extracting solvent to the medicinal materials is (8-16)ml:1g; filtering the extract, reclaiming the filtrate at reduced pressure to extract the solvent to obtain concentrate, and drying to obtain a coarse product of tripterygium wilfordii extract; and (3) adding 5.0-15.0g of the coarse product of tripterygium wilfordii extract into a solvent for re-dissolving, wherein the usage ratio of the solvent to the coarse product of tripterygium wilfordii extract is (10-15)ml:1g, filtering, and reclaiming the solvent at reduced pressure to obtain the tripterygium wilfordii extract. The invention also discloses a medicament prepared from the tripterygium wilfordii extract for treating rheumatoid arthritis. The content of total triterpenes of the prepared tripterygium wilfordii extract is 50-75 percent, so that the utilization of a tripterygium wilfordii medicinal material is improved, and the toxicity of the tripterygium wilfordii medicinal material is reduced.
Owner:ZHEJIANG CHINESE MEDICAL UNIVERSITY +2

Method for preparing lipid-lowering chewable tablet of four leaves

The invention discloses a method for preparing a lipid-lowering chewable tablet of four leaves. The method comprises the following steps: firstly, crushing lotus leaf, folium mori, ginkgo leaf and chrysanthemum leaf to obtain powder a; carrying out supercritical CO2 extraction on the powder a to obtain an extract solution; refrigerating at 0-5 DEG C for 12 hours; carrying out suction filtration, extraction, vacuum concentration and vacuum drying to obtain a dry extract; crushing to obtain extract powder; then drying the lotus leaf and smashing by using an ultrafine grinder to obtain lotus leaf superfine powder; putting skim milk powder and microcrystalline cellulose into a mortar to grind and evenly mix, so as to obtain powder b; evenly mixing the extract powder with the powder b; adding the lotus leaf superfine powder, and evenly mixing to obtain a mixture; adding polyvinylpyrrolidone to the mixture to prepare a soft material; adding superfine silica powder after pelletizing and straightening, and then tabletting, so as to obtain the lipid-lowering chewable tablet of the four leaves. The lipid-lowering chewable tablet of the four leaves disclosed by the invention can be used for effectively reducing the weight, the fat and the liver weight of mice, and has latent effects of reducing weight and lowering lipid.
Owner:ANHUI XINHUA UNIV

Coumarin and phenylchromone extract from angelica polymorpha maxim and preparation method and use thereof

The invention relates to an angelica polymorpha maxim extract, which contains coumarin and phenylchromone components, wherein the coumarins include one or more of oxypeucedanin hydrate, pabulenol, isoimperatorin, osthol, bergapten, imperatorin, 22,23-dihydroavermectin, isopimpinellin and oxypeucedanin ethylether; and the phenylchromones include one or more of 3'R-(+)hamaudol, 3',-O-acetylhamaudol, angeliticin and ledebouriellol. The invention also relates to a preparation method, a quality control method and a medicinal composition of angelica polymorpha maxim extract and use of the angelica polymorpha maxim extract in the preparation of medicines or products for treating pain and / or inflammatory disorders. The experiments on the pharmacodynamic and acute toxicity of the extract indicate that the extract has the advantages that: the active ingredients are clear; the medicinal effect is remarkable; the toxic and side effects are small; the product quality is high; the dosage is small; the quality is controllable; and the like.
Owner:INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A

Clothianidin and beta-cyfluthrin suspending agent and preparation method thereof

The invention relates to a clothianidin and beta-cyfluthrin suspending agent and a preparation method thereof. The suspending agent is prepared from the following raw materials in parts by weight: 20-25 parts of clothianidin, 5-10 parts of beta-cyfluthrin, 4-7 parts of a composite dispersing agent, 0.2-0.6 part of a nonionic lipid emulsifier, 0.3-0.7 part of an anionic sulfonate wetting agent, 3-5parts of an anti-freezing agent, 1-1.5 parts of a thickening agent, 0.1-0.3 part of a preservative, 0.5-1 part of a regulator and 0.1-0.5 part of a defoaming agent , with the balance being water. Thesuspending agent provided by the invention is prepared by adding the composite dispersing agent, the nonionic lipid emulsifier and the anionic sulfonate wetting agent into effective components; through a compounding effect of the composite dispersing agent, the nonionic lipid emulsifier and the anionic sulfonate wetting agent, the mixing uniformity of the components of the suspending agent can besignificantly improved; the wetting and dispersing effects of the suspending agent on the surface of the root part of garlic can be enhanced; thus, the pesticide effect of the suspending agent is exerted to a maximum extent when the suspending agent is used in a low-temperature environment; and by addition of the anti-freezing agent, the storage stability of a product can be easily kept when thesuspending agent is used in the low-temperature environment.
Owner:南京保丰农药有限公司
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