The invention discloses a preparation method of Trichosanthes kirilowii Maxim oral liquid, comprising the following steps: step 1, weighing raw materials: weighing 19-21 parts of Agastache rugosus, 56-64 parts of Mangnolia officinalis, 19-21 parts of white paeony root, 9-10 parts of delavay soapberry pericarp seed, 9-11 parts of Platycodon grandiflorum, 14-16 parts of apricot kernel, 60-80 parts of Trichosanthes kirilowii Maxim, 9-13 parts of Angelica sinensis, and 19-21 parts of peach kernel. Trichosanthes kirilowii Maxim added in the invention has the effects of moistening lung for removingphlegm, smoothing intestine and relaxing the bowels and is mainly used for cough caused by dryness and phlegm and constipation due to intestinal dryness; Mangnolia officinalis has therapeutical effecton diseases such as dyspepsia and qi stagnation, abdomen distension and constipation, damp retention in middle-jiao and the like; Angelica sinensis has effects of invigorating qi and blood, regulating menstruation and relieving pain, moistening dryness and smoothing intestine; white paeony root has efficacy of warming yang and eliminating dampness, tonifying body deficiency, strengthening spleenand stomach, etc.; and peach kernel has the effect of promoting digestion and removing food retention. By combining the various medicines to achieve the effects of tonifying middle-Jiao and qi, tonifying spleen and promoting circulation, the oral liquid of the invention is used for treating constipation.