Sinomenine preparation and preparation method thereof

A technology of sinomenine and sinomenine, which is applied in the field of sinomenine preparations and its preparation, can solve problems such as ostrich oil that has not yet been seen, and achieve the effects of improving transdermal effect, improving drug efficacy, and reducing skin irritation

Active Publication Date: 2014-04-02
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no research report on the application of ostrich oil to traditional Chinese medicine preparations, especially the percutaneous absorption of sinomenine

Method used

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  • Sinomenine preparation and preparation method thereof
  • Sinomenine preparation and preparation method thereof
  • Sinomenine preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 50g of ostrich oil, heat it to 42°C, make it melt into a liquid, gradually add 100mg of sinomenine powder passed through an 80 mesh sieve, stir at high speed for 30 minutes to make it evenly dispersed, then gradually add 50mg of eucalyptus oil, 500mg of vitamin C E, continue stirring for 30 minutes to make the system uniform. Naturally cool to room temperature to obtain a solid paste, which can be packaged.

Embodiment 2

[0016] Take 100g of ostrich oil, heat it to 44°C, melt it into a liquid state, gradually add 500mg of sinomenine powder passed through an 80-mesh sieve, stir at high speed for 30 minutes to disperse evenly, then gradually add 1g of eucalyptus oil, 500mg of vitamin E, Stirring was continued for 30 minutes to make the system uniform. Naturally cool to room temperature to obtain a solid, which can be packaged.

Embodiment 3

[0018] Take 200g of ostrich oil, heat it to 46°C, melt it into a liquid state, gradually add 4g of sinomenine powder passed through an 80 mesh sieve, stir at high speed for 30 minutes to make it evenly dispersed, then gradually add 400mg of eucalyptus oil, 1.6g of vitamin E , and continue stirring for 30 minutes to make the system uniform. Naturally cool to room temperature to obtain a solid, which can be packaged.

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Abstract

The invention aims to provide a sinomenine preparation. The preparation is prepared from sinomenine with a proper concentration, ostrich oil, vitamin E with a proper concentration and eucalyptus oil. The preparation method comprises the following steps: heating and melting the ostrich oil into liquid; adding sinomenine powder, and uniformly stirring and dispersing; adding eucalyptus oil and vitamin E, stirring and cooling. According to the preparation, the transdermal effect of sinomenine can be improved and the drug effect of the medicine can be improved; ostrich oil is a pure natural raw material, is capable of reducing skin irritation when used as a drug-loading matrix; in addition, ostrich oil has arthritis resistance and can realize arthritis treatment when used together with sinomenine.

Description

technical field [0001] The invention belongs to the field of pharmaceuticals, and relates to a preparation method of a pharmaceutical preparation, in particular to a novel sinomenine preparation using a natural penetration enhancer and a preparation method thereof. Background technique [0002] Sinomenine (sinomenine) is an alkaloid monomer extracted from Qingfengteng. It has anti-inflammatory, analgesic and anti-arrhythmic effects. Clinically, there are Zhengqing Fengtongning Tablets, Sustained-release Tablets, and Sinomenine Hydrochloride Injection And other preparations are used to treat arthritis, chronic nephritis, ankylosing spondylitis, arrhythmia, etc., with remarkable curative effect. In recent years, scientific research has also discovered other pharmacological activities of sinomenine, such as immunosuppression, anti-oxidation, anti-tumor, cancer treatment, drug rehabilitation, etc. [0003] Clinical trials have shown that sinomenine has a short biological ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/485A61K31/473A61K35/12A61K47/44A61P9/06A61P19/02A61P29/00A61K35/57
Inventor 王龙虎陈誊王琼刘欣王长根刘雪松
Owner ZHEJIANG UNIV
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