78 results about "Fluvastatin" patented technology

A solid dispersion composition containing fluvastatin and a polymer is provided. Optionally, a surfactant is included. The fluvastatin appears to be amorphous and the solid dispersion composition enables fluvastatin to be constantly released over a time period.

Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentation using microorganisms of different species identified as species belonging to Aspergillus, Monascus, Nocardia, Amycolatopsis, Mucor or Penicillium genus, and some are obtained by treating the fermentation products using the methods of chemical synthesis or they are the products of total chemical synthesis. The aforementioned active substances may be destabilised by the environmental factors, their degradation may also be accelerated by interactions with other pharmaceutical ingredients, such as fillers, binders, lubricants, glidants and disintegrating agents, therefore the pharmaceutical ingredients and the process for preparation of the pharmaceutical formulation should be meticulously chosen to avoid the aforementioned undesired interactions and reactions. The present invention relates to a stable solid pharmaceutical formulation for the treatment of hypercholesterolemia and hyperlipidemia. More precisely, the present invention relates to the new stable solid pharmaceutical formulation containing as an active ingredient a HMG-CoA reductase inhibitor, such as atorvastatin, pravastatin, fluvastatin and cerivastatin or pharmaceutically acceptable salts thereof.

The invention belongs to the technical field of gene mutation detection, and concretely discloses a kit for simultaneously detecting SLCO1B1, APOE and LDLR gene multisite mutation. Through meticulous design, multi-time verification, screening and optimization, specific primers and probes based on a Taqman allelic gene resolution analysis method are obtained; eight functional variation of the SLCO1B1, APOE and LDLR genes can be detected; the time from DNA (Deoxyribonucleic Acid) extraction to fluorescent PCR (Polymerase Chain Reaction) to result obtaining is less than four hours; and the manual operation time is less than two hours. The kit comprising the primer pairs and the probe pairs has the advantages that the time is saved; convenience is realized; the sensitivity is high; and both the positive conformity rate and the negative conformity rate of a sample are higher than 99 percent, and the like. A detection method provided by the invention is mainly used for the personalized medication auxiliary diagnosis of statins such as simvastatin, atorvastatin, fluvastatin and rosuvastatin.

The present invention relates to optically active boronate derivatives which are useful as intermediates for the synthesis of HMG-CoA enzyme inhibitors such as atorvastatin, cerivastatin, rosuvastatin, pitavastatin, and fluvastatin.

The invention provides a fluvastatin preparation without stabilizing agents. The fluvastatin preparation is characterized in that the fluvastatin preparation does not contain alkalizers for elevating the pH value of the preparation; fluvastatin is dispersed on pharmaceutically applicable polymer carriers to achieve the aim of stabilization; and the polymer carriers are selected from one or more of polyethylene glycols, polyvidones, surfactants containing polyoxyethylene groups, water-soluble cellulose derivatives, organic acids, saccharides and alcohols. The preparation can be prepared by a freeze drying method.

The invention relates to an osmotic pump preparation containing acipimox, fluvastatin and other pharmaceutical excipients, wherein, the acipimox is the controlled-release part, the fluvastatin is the rapid-release part; or the acipimox and the fluvastatin are both the controlled-release parts. In addition, the invention further discloses a preparation method of osmotic pump tablets of the composition, and the osmotic pump table which is prepared by applying the method can better bring the synergy of the acipimox and the fluvastatin into play.

The invention relates to a statin-double phosphonate coupling compound for curing osteoporosis and other bone calcium metabolic diseases and a preparation process and an application, in particular to an atorvastain or fluvastatin-coupling compound and a synthesis and an application. The invention comprises mixing fluvastatin lactone or atorvastain lactone and double phosphonate according to statin lactone: double phosphonate ester= 1:1-3, obtaining statin double phosphonate coupling compound, and then obtaining salt through the reaction of the 1:4-20:4-20 proportion of double phosphonate coupling compound: 2, 4, 6-trimethyl pyridine: trimethyl bromo-silicane in solution with below 5-10 DEG C of reaction temperature. The synthesis process of the invention is simple, which can synthesize eight new compounds, namely that four new intermediate compounds and four target compounds, and provides an effective medicament for preventing and curing osteoporosis and other bone calcium metabolic diseases.

The invention relates to a choline salt of a hypolipidemic drug and a preparation method and a pharmaceutical use thereof. The invention provides a choline salt of a class of hypolipidemic drugs, and the hypolipidemic drugs include but not limited to clofibrate, libet, fenofibrate, ciprofibrate, gemfibrozil, acipimox, niacin, lovastatin, simvastatin, pravastatin, fluvastatin, atorvastatin, rosuvastatin, pitavastatin, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and other unsaturated fatty acids. The choline salt of the hypolipidemic drug can be used for treating hyperlipidemia and other cardiovascular diseases. The invention also provides a preparation method of the choline salt of the hypolipidemic drug.

A composition for increasing the bioavailability of a statin active pharmaceutical ingredient (“API”) in humans and animals, wherein that composition includes a statin API selected from the group consisting of atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin, a first water soluble surfactant having a cloud point greater than about 37° C., a second water soluble surfactant having a cloud point greater than about 37° C., wherein a mixture of the first surfactant and the second surfactant comprises a cloud point less than about 37° C.

This invention is directed towards a ready-to-use aqueous composition of fludarabine phosphate. In one embodiment, the invention is directed to an aqueous fludarabine phosphate composition which comprises fludarabine phosphate, a base, and water. The concentration of fludarabine phosphate in the composition may be between about 0.5 mg / mL and about 50 mg / mL. The pH of the composition may be between about 5.5 and about 7.1.

The present invention provides a drug composite for treating hyperlipidemia, the characteristics of which lies in containing effective amount Acipimox and Fluvastatin natrium, the weight ratio is (5~30):1, the optimal selection weight ratio is (5~15):1, the further optimal selection weight ratio is 10:1. The lipid-lowering effect is superior to the simple recipe with same dose significantly, which shows that there is synergistic effect and no distinct toxicity function under taking the Acipimox and the Fluvastatin both.

The invention discloses a specific primer probe combination for guiding a fluvastatin drug individualized drug use related gene SNP, and is characterized in that the primer probe combination includesa specific primer probe combination for rs4783961, rs11045819 and rs1922242 genes SNP. The invention also provides a kit containing the primer combination and an application thereof. The beneficial effects comprise that provided are the quick typing kit for guiding the fluvastatin drug individualized drug use related gene SNP and the application thereof. The test result obtained by the kit is accurate and reliable, the cost is low, and the kit has good practicability.

The invention provides an eutectic compound comprising a proton pump inhibitor and a hydroxy-3-methylglutaryl coa reductase inhibitor. The eutectic compound is characterized in that the proton pump inhibitor is selected from one in omeprazole, esomeprazole, pantoprazole, rabeprazole and lansoprazole; the hydroxy-3-methylglutaryl coa reductase inhibitor is selected on or pharmacologically acceptable salt thereof in atorvastatin, rosuvastatin, simvastatin, fluvastatin, pravastatin, lovastatin and pitavastatin. The eutectic compound can produce a synergistic bacteriostatic effect.

The present invention relates to pharmaceutical compositions for sustained release comprising a water soluble salt of the HMG-CoA reductase inhibitor fluvastatin as active ingredient, said composition being selected from the group comprising matrix formulations, diffusion-controlled membrane coated formulations; and combinations thereof.