225 results about "Therapeutic effectiveness" patented technology

An apparatus and method for a bi-level positive airway pressure support in which the rise time from the expiratory positive airway pressure to the inspiratory positive airway pressure is automatically controlled by the pressure support system. The pressure support system includes a sensor, a control system, and a pressure generating system. The sensor monitors the patient's respiration to detect respiratory events, such as an apnea, hyponea or other disturbance, and the control system responds to the sensor information to adjust the rise time from the expiratory positive airway pressure to the inspiratory positive airway pressure gas pressure to maximize patient comfort and pressure support treatment effectiveness.

A method and apparatus for facilitating placement and evaluation of virtual appliances on virtual teeth of an orthodontic patient are described. Positioning references comprising bracket height, occlusal plane, or any arbitrary plane are provided to facilitate desired placement of virtual appliances on virtual teeth model. The process can be applied with any dentition state of a patient such as malocclusion, target state from treatment, or intermediate monitored state during the course of a treatment. An unified workstation for treatment planning provides the computer software tools for verification, simulation and evaluation of the virtual appliance placement. The process enables proper planning of treatment for an orthodontic patient suffering from malocclusion involving bonding of virtual brackets to the surface of the patient's virtual teeth with archwires placed in the slots of the brackets, so as to realize the desired results from the treatment in the most desired manner.

A self-contained respiratory apparatus, including a blower delivering a gas, a headgear integrated with the blower to support a respiratory interface, and a sensor embedded in the headgear and mounted to deliver data to a microprocessor integrated with the blower, the blower being controlled through the response of the sensor and the control of the microprocessor to support the respiratory interface through the headgear.

The invention encompasses systems, methods, and apparatus for predicting and monitoring an individual's response to a therapeutic regimen. The invention includes multiple virtual patients, an associating subsystem operable to associate the subject with one or more of the virtual patients, and a simulation engine operable to apply one or more experimental protocols to the one or more virtual patients identified with the subject to generate a set of outputs. The set of outputs can represent therapeutic efficacy, identify biomarkers for monitoring therapeutic efficacy, or merely report the status of the biological system as it represents a particular individual

The present invention provides pharmacogene polymorphisms and their use in predicting therapeutic effectiveness. The present invention also provides methods comprising targeted analysis of selected pharmacogenes in thousands of compiled whole human genome sequences for identifying polymorphic sequences associated with drug response are described. The methods also provide confirmation and validation of these pharmacogene polymorphisms, based on concordance between different sequencing technologies, and statistical error-checking. Imputation of the deleterious consequences of novel variants is predicted by bioinformatics analysis.

The present invention provides methods of detection, including early detection, for cancer or other diseases and normal physiologic processes mediated by global epigenetic changes, by using one or more of the following biomarkers: a global DNA methylation index, a global histone H4 acetylation index, and a global histone H4 trimethylation index. These methods are useful for, among other things, assessing the effectiveness of treatment, monitoring relapse, and clinical staging of cancer and other chronic as well as acute diseases. These methods are also useful for among other things monitoring the effectiveness of strategies and therapies used to modify lifestyle and contextual effects to prevent disease, foster wellness and enable health promotion.

The invention discloses a remote implantable medical device monitoring system, which comprises an implantable medical device implanted in the body of a patient, a patient controller, a doctor program controller and a remote medical system. A multimedia electronic device of a patient terminal transmits the video and / or audio information of the patient to a doctor via the remote medical system, the doctor analyzes the audio / video information and the parameter information of the implantable medical device and then uses the doctor program controller to transmit monitoring information to the patient controller via a wireless remote communication network, the patient controller transmits the received monitoring information to the implantable medical device, and thereby the implantable medical device can be remotely monitored. Compared with the prior art, the implantable medical device can be remotely monitored without requiring the patient to go a long way to a hospital, consequently, the curative effect of the patient is greatly enhanced, the time of the doctor and the patient is saved, and the economic burden of the patient is relieved.

The present invention relates to a method for the treatment of depression comprising administering a therapeutically effective amount of gaboxadol to a patient, wherein the level of one or more inflammatory markers in said patient is increased or abnormal. The present invention also relates to a method for the treatment of stress-mediated depression comprising administering a therapeutically effective amount of gaboxadol to a patient, wherein the level of one or more inflammatory markers is increased or abnormal in said patient. The present invention also relates to a method for the treatment of depression or the amelioration of one or more depressive symptoms comprising administering a therapeutically effective amount of gaboxadol to a patient, wherein the clinical presentation of one or more symptoms of depression are the physiological effect of a general medical condition. Furthermore the present also relates to a method for testing the therapeutic effectiveness of a compound in the treatment of depression or reducing the symptoms of depression comprising measuring the amount of one or more inflammatory markers in a sample from a patient before said compound is administered to the patient and comparing with the amount of said one or more inflammatory markers in a sample from the same patient after administration of said compound to the patient.

Systems for and methods of assessing lower urinary tract function from urinary flow data via sound analysis and user-provided information regarding the lower urinary tract symptoms (LUTS) of frequency, urgency and urge incontinence. Embodiments of the LUTS assessment systems include a computer and a telephone or a digital recording mechanism to capture the sound of one or more urination events, which are stored as audio files in a database. The LUTS assessment systems may include sound analysis software for analyzing the strength and duration of each urination event and may include a web-based software application for viewing the results via the Internet or other network. The database stores information from multiple urination events, and combined with information regarding the lower urinary tract symptoms, serves as an objective tool to assess bladder function and monitor progression of disease or therapy effectiveness.

The invention discloses an automatic drug checking system based on an electronic anamnesis, which comprises a bar code scanner, an electronic anamnesis system communication interface, a drug checking system communication interface, a communication module, an input module, a display module and a controller, wherein the bar code scanner, the communication module, the input module and the display module are all connected to the controller; and the controller communicates with the electronic anamnesis system interface and the drug checking system communication interface through the communication module. According to the invention, a patient can check whether purchased drugs are consistent with a prescription in the anamnesis of the patient, whether the quality of the purchased drugs has problems and the like through the system; therefore, the phenomenon that wrong drugs are obtained by mistake of personnel or the drugs of poor quality are purchased is avoided to occur; and thereby, a treating effect on the patient is ensured.

The present invention relates to the use of MRI monitoring of ventricular enlargement rate as an objective measure for the purpose of assessing disease progression in patients suffering from Alzheimer's disease and for the purpose of determining therapeutic effectiveness of a treatment regimen for Alzheimer's patients. Methods for treating Alzheimer's Disease and monitoring therapeutic effectiveness are provided.

The invention discloses a hypertension patient monitoring method based on a grassroots medical platform. The hypertension patient monitoring method comprises that the grassroots medical platform monitors the blood pressure value of a user at the preset time with a preset monitoring period according to a user diagnosis and treatment plan acquired from a network hospital platform; the grassroots medical platform compares the blood pressure value of the user at the preset time with the blood pressure threshold at the corresponding time in the user diagnosis and treatment plan, and the comparison result within the preset monitoring period is recorded; the grassroots medical platform determines a blood pressure monitoring result within the monitoring period according to the comparison result within the preset monitoring period, and sends a blood pressure adjusting plan corresponding to the blood pressure monitoring result to the user in order to make the user execute the blood pressure adjusting plan. The invention also discloses a grassroots medical platform. The grassroots medical platform is in butt joint with the network hospital platform, parameter monitoring, prompting and intervention are carried to a hypertension patient according to the user diagnosis and treatment plan, and therefore the treatment progress of the hypertension patient is accelerated, and the treatment effect of the hypertension patient is improved.

The present invention relates to a method for diagnosis of different stages of endometrial cancer in an individual. Further, the present invention relates to a method for evaluating the probability of survival for an individual suffering from endometrial carcinoma. In another aspect, the present invention relates to the stratification of therapy regimen of endometrial tumor, ovarian cancer, breast cancer, non-small lung cancer or hormone refractory prostate cancer therapy in an individual or monitoring therapeutic efficacy in an individual suffering from the same based on the expression status of STMN1 gene or protein. Moreover, the present invention relates to a kit for use in any of the above referenced methods comprising a means for determining amplifications and deletions of chromosomal regions 3q26.32 and 12p12.1, determining alterations of the gene expression profile of the genes (gene signature): upregulation of the genes PLEKHK1, ATP10B, NMU, MMP1, ATAD2, NETO2, TNNI3, PHLDA2, OVOL1 and down-regulation of the genes: NDP, KIAA1434, MME, CFH, MOXD1, SLC47A1, RBP1, PDE8B, ASRGL1, ADAMTS19, EFHD1, ABCA5, NPAS3, SCML1, TNXB, ENTPD3, AMY1A, ENPP, RASL11B, PDZK3, or the expression status of the STMN1 gene or protein, respectively. Finally, the present invention provides a method for predicting the response to taxanes in an individual suffering from a disease treated with the taxanes based on the expression status of the STMN1 gene or protein.

A method for diagnosing and treating sleep disorders with a sleep therapy auto-titrator for in-home use by the patient includes the step of collecting, recording and analyzing sleep data in real time with the auto-titrator. Corrective action is provided in real time to the patient to mitigate sleep events based upon the collected sleep data. The collected sleep data is transmitted, via a global computer information system, to a remote server for storage. The stored sleep data is analyzed by a computer programmed with an algorithm to monitor therapy effectiveness daily and for identifying one or more therapy intervention recommendations. An alert is provided to at least one of the patient or a sleep therapy professional associated with the patient communicating the one or more intervention recommendations.

A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the mass / charge spectrum. The MSCs are effective in yielding reproducible extracts from complex biological samples as small as 10 μl in a time as short as 30 minutes. They are inexpensive to manufacture, and allow for scaled up production to attain the simultaneous processing of a large number of samples. The MSCs are multiplexed, label-free diagnostic tools with the potential of biological recognition moiety modification for enhanced specificity. The MSCs may store, protect and stabilize biological fluids, enabling the simplified and cost-effective collection and transportation of clinical samples. The MSC-based device may serve as a diagnostic tool to complement histopathology, imaging, and other conventional clinical techniques. The MSCs mediated identification of disease-specific protein signatures may help in the selection of personalized therapeutic combinations, in the real-time assessment of therapeutic efficacy and toxicity, and in the rational modulation of therapy based on the changes in the protein networks associated with the prognosis and the drug resistance of the disease.

The present invention provides a mattress system (1) devised to achieve a function of automatic detection, mainly comprising: a mattress (2) having a simple structure; a control unit (3) equipped with a unique user interface (31) for caregivers to simultaneously adjust three major functions, namely, therapy mode, therapy intensity and comfort level; and a connection pipe (4) for supplying air and power. The system (1) is further provided with a built-in auto-setting function to sense the body characteristics of the patient (39) lying on the mattress (2) and determine an effective supporting pressure range for the patient (39). By detecting a pressure difference representing the body characteristics of the patient (39) lying on the mattress (2) and comparing with the data stored in a built-in database, the system (1) can always provide the patient (39) with not only a well-proved therapeutic effect through the auto-setting function, but also an adjustable comfort level on the patient's request through the user interface (31).

A method of assessing kidney function in a human subject to aid in the diagnosis of renal tubule diseases or conditions specific to a particular renal tubule region, comprises contacting a urine sample from said subject with a panel of capture molecules, each capture molecule being capable of binding to a specific biomarker from at least one of the four major regions of the renal tubule, in particular the proximal, distal, collecting duct and loop of Henle regions, the detection of one or more biomarkers in the urine sample being indicative of damage in a corresponding region of the renal tubule. The method facilitates inter alia the non-invasive detection of renal tubule damage and serves as a prognostic method to determine the level of tubule damage and monitor the effectiveness of therapeutic treatment.

The invention relates to a ciclopirox olamine pessary capable of reducing toxic and side effects of a medicament caused by systemic delivery, increasing local concentration of the medicament, fully playing the therapeutic effectiveness of the medicament and improving the adaptability of patients. The pessary can realize zero order release and is prepared by the following materials by weight portion: 1 portion of ciclopirox olamine, 65 to 90 portions of substrate, 0.2 to 3 portions of stearic acid, 0.1 to 5 portions of hydrogenated castor oil and 0.05 to 2 portions of sodium benzoate.

The invention relates to an olive tablet and the preparation method. The olive tablet is made by the following raw materials according to the weight percentage: emblic leafflower finemeal of 40 percent to 48 percent, rock candy powder of 50 percent to 60 percent, menthol of 0.1 percent to 0.3 percent, vanillin of 0.1 percent to 0.3 percent, protein candy of 0.1 percent to 0.3 percent, stearic acid of 1.0 percent to 2.0 percent and lemon flavor of 0.1 percent to 0.3 percent. The olive tablet of the invention has the advantages of sweet taste, body fluid production and long aftertaste; and the olive tablet is suitable for long-term consumption, and has the unique therapeutic effectiveness of throat smooth, lung moistening and fast effect, thereby which is an essential health product at home and for travel.

This disclosure provides systems and methods for patient-specific identification and assessment of ocular disease risk factors and efficacy of various treatments. The systems and methods can include mathematically modeling an expected normal patient-specific value of one or more clinically observable properties using a patient-specific mathematical model that can be calibrated with patient-specific data. The expected normal patient-specific value can be compared with a measured patient-specific value. A greater difference between the expected and measured patient-specific values can correlate to greater ocular vasculature abnormalities.

The present invention relates generally to a population of cells genetically modified to comprise pancreatic islet glucokinase and capable of producing insulin in a glucose responsive manner and uses thereof. More particularly, the present invention relates to a population of cells so genetically modified capable of producing insulin in response to physiologically relevant levels of glucose and uses thereof. The cells of the present invention are useful in a wide variety of applications, in particular in the context of therapeutic and prophylactic regimes directed to the treatment of diabetes and / or the amelioration of symptoms associated with diabetes, based on the transplantation of the cells of the present invention into mammals requiring treatment. Also facilitated is the design of in vitro based screening systems for testing the therapeutic effectiveness and / or toxicity of potential adjunctive treatment regimes.

Systems for and methods of assessing lower urinary tract function from urinary flow data via sound analysis and user-provided information regarding the lower urinary tract symptoms (LUTS) of frequency, urgency and urge incontinence. Embodiments of the LUTS assessment systems include a computer and a telephone or a digital recording mechanism to capture the sound of one or more urination events, which are stored as audio files in a database. The LUTS assessment systems may include sound analysis software for analyzing the strength and duration of each urination event and may include a web-based software application for viewing the results via the Internet or other network. The database stores information from multiple urination events, and combined with information regarding the lower urinary tract symptoms, serves as an objective tool to assess bladder function and monitor progression of disease or therapy effectiveness.

A head rehabilitation system and a multifunctional cervical vertebra parting therapy apparatus formed by the same; the head rehabilitation system comprises an upper fixed plate, a rotary mechanism and a drawing mechanism; the rotary mechanism comprises a rotary motor fixed on the upper fixed plate; the rotary motor output end is provided with an adjusting disc. One end of a universal coupling is arranged in an adjusting disc groove, i.e., drifts away from the adjusting disc center; the rotary motor drives the adjusting disc to rotate; the adjusting disc drives one end of the universal coupling to swing; the universal coupling motions comprise vertical directions and horizontal directions; the universal coupling drives a swing rod to make synthesis motions in opposite directions; a middle frame and a heat cap swing with the swing rod; the head cap makes swing motions similar to a horn type; a drawing motor draws the head cap through a drawing belt, so a patient can synchronically swing in traction treatment, and the head can make multidirection motions; the system is large in motion amount and good in treatment effect; the vibration amplitude of the head cap can be adjusted according to the position of the universal coupling on the adjusting disc; the head rehabilitation system is suitable for different patients.

The present invention relates to a therapeutic contact lens wherein a therapeutic medicine can be accommodated between an eyeball and a lens, thereby improving the effect and speed of eye treatment. The therapeutic contact lens according to the present invention comprises: a main body of a lens having a spherical surface for allowing the lens to be worn on the eye; an accommodation portion formed to be inward facing the side at the inner surface of the main body of a lens coming in contact with an eyeball; and a medicine portion accommodated in the accommodation portion to deliver a medicine ingredient to the eyeball when the main body of a lens is worn. The accommodation portion can be formed in the form of a circular inlet groove having a predetermined diameter at the center of the inner surface of the main body of a lens, a light transmission portion is formed at the center of the main body of a lens to allow a wearer to see frontward, and the accommodation portion can be formed in a ring shape along the edge of the light transmission portion.

The invention discloses a hysteroscope with multiple mechanical channels. The hysteroscope includes an insertion part and an operation part, the operation part comprises a hand shank and a handle forming a certain angle with the hand shank, the hand shank is provided with at least two mechanical inlet nozzles, a mechanical outlet is formed in the front end surface of the insertion part, and each mechanical inlet nozzle is communicated with the mechanical outlet through the mechanical channels running through the interior of the hand shank and an inner cavity of an insertion pipe; the handle isprovided with a water inlet base and a water outlet base, the front end of the insertion part is provided with a water inlet and a water outlet, the water inlet base and the water outlet base are communicated with the water inlet and the water outlet through a water inlet channel and a water outlet channel which run through the interior of the hand shank and the inner cavity of the insertion piperespectively. Since the hysteroscope is provided with the two mechanical channels, two medical instruments can be inserted into the human body at the same time for treatment, and the two medical instruments can also cooperate with each other to achieve a better treatment effect, so that the operation time is greatly shortened, the pain of a patient is relieved, the effect of operation treatment is improved, and the hysteroscope has high practical value.

The invention discloses a staggered massaging type cervical vertebra rehabilitation treatment device. The staggered massaging type cervical vertebra rehabilitation treatment device comprises an arc-shaped hollow plate, a belt wheel, a hollow column, massaging balls, a connecting rod, a driving device and a head back supporting device. The rehabilitation treatment device has the beneficial effects that a jacking bolt is screwed off and screwed on to adjust the height of a head back supporting plate, so that patients with different body forms can utilize the rehabilitation treatment device relatively comfortably; the connecting rod circularly moves up and down, so that the massaging balls can be used for carrying out hammering type massaging on necks of the patients when the massaging balls are located on the uppermost side; the massaging balls are used for massaging the necks of the patients in a staggered manner and the massaging efficiency is improved; three continuous U-shaped rotary rods are arranged, so that the necks of the patients can be massaged at a plurality of angles at the same time; in a massaging process, an electric heating rod is used for heating and medicine liquid injected into a medicine liquid cavity is heated; and medicine liquid gas at a certain temperature overflows through a gas medicine through hole, and medicines are applied to cervical vertebras of the patients, so that the cervical vertebra rehabilitation effect on the patients is relatively good.

The present invention relates to the use of the level of certain cytokines in a patient's blood as an objective measure for the purpose of assessing disease progression in patients suffering from Alzheimer's disease and for the purpose of determining therapeutic effectiveness of a treatment regimen. Methods for treating Alzheimer's disease and monitoring therapeutic effectiveness are provided.

The invention discloses an intelligent ultrasonic physiotherapy device through blood pressure signal control and an implementation method of the device and belongs to the technical field of ultrasonic therapy instruments. The device comprises a system control module, a DDS numerical control frequency source module, a pulse blood pressure acquiring and processing module, a valve module, a high-frequency generator module, an ultrasonic transducer and a frequency monitoring module, wherein the DDS numerical control frequency source module is used for generating ultrasonic frequency square wave signals, the pulse blood pressure acquiring and processing module is used for measuring high blood pressure and low blood pressure of a human body and using the average value of the high blood pressure and the low blood pressure as a parameter for controlling ultrasonic output power, and then pulse signals are acquired and processed by the pulse blood pressure acquiring and processing module so that TTL level control signals synchronous with pulses can be generated. According to the intelligent ultrasonic physiotherapy device through blood pressure signal control and the implementation method of the device, the blood pressure signals of the human body are used as the parameters for controlling the ultrasonic output power, the ultrasonic output power can be adjusted according to the physical conditions of the human body, the ultrasonic therapy application range can be wider, and the therapeutic effect can be better.