65 results about "Acute diseases" patented technology

The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention.

The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention.

The invention relates to the treatment multiple sclerosis, and in particular to the treatment of the inflammatory injury seen in the progressive stages in the disease such as seen with the recurrent upsurges of acute disease, classically known as “relapses” or “exacerbations” or “relapsing / remitting” disease seen in multiple sclerosis. The invention provides a method for modulating a relapsing / remitting disease in a subject suffering therefrom involving providing the subject with a gene-regulatory peptide or functional analogue thereof. Furthermore, the invention provides the use of an NF-κB down-regulating peptide or functional analogue thereof for the production of a pharmaceutical composition for the treatment of relapsing / remitting disease as seen with multiple sclerosis.

A system and method for perceiving and relaxing emotions are described. The system includes a biosensor, an emotion database, a media player, and an emotion analysis module. According to the method, first, the biosensor detects bio-signals from an individual. Next, the emotion analysis module analyzes the bio-signals to construct a 3D emotional coordinate system, then calculates the position of the bio-signals in the 3D emotional coordinate system to determine the emotional state of the individual, and obtains a media information corresponding to the emotional state information from the emotion database. Afterward, the media information is played by the media player to stabilize the emotion of the individual. In this manner, the emotion of the individual is controlled in a stable and safe way, thus preventing causing any physiological or inveterate diseases of the individual. This method is applicable to perform long-term medical monitoring and treatment on patients with chronic / acute diseases.

The present invention provides methods of detection, including early detection, for cancer or other diseases and normal physiologic processes mediated by global epigenetic changes, by using one or more of the following biomarkers: a global DNA methylation index, a global histone H4 acetylation index, and a global histone H4 trimethylation index. These methods are useful for, among other things, assessing the effectiveness of treatment, monitoring relapse, and clinical staging of cancer and other chronic as well as acute diseases. These methods are also useful for among other things monitoring the effectiveness of strategies and therapies used to modify lifestyle and contextual effects to prevent disease, foster wellness and enable health promotion.

The invention belongs to the medical apparatus technique field, especially relating to a micro-trauma perforator used in neurological clinical surgery, comprising: a drill body (2), a cranked handle (7), a axis (3), a axis (4), a chuck (12), a drill bit (13) and a couple of meshed bevel gears (10) and (11). Wherein, the drill body (2) is in the shape of arch; the bevel gear (10) is mounted on the axis (3) and the bevel gear (11) is mounted on the axis (4) while said two axes are mutually perpendicular mounted in the drill body (2); the bevel gear (1) is integrated to the cranked handle (7) via the handle swinging arm (6), the nut (9) mounted on the swinging arm (6) and the pressing nut (8); the chuck (12) is mounted on the outer side of drill body (2) and connected to the axis (4) as a whole; a handle (1) is arranged under the drill body (2) on which a finger concave (16) is arranged; and a scale (14) is on the drill bit (13) whose top drill point (15) is flat and sharp. The invention has simple structure while it can be used easily and fast with little trauma, therefore, it reduces the suffering of patient. The invention is worth to spread in the application of neurological clinical surgery especially in the salvage of acute disease macroporosity hernia cerebra patient and the patients that needing the surgery of ventricle external conduction.

The invention relates to a heart disease risk diagnosis method based on a deep convolutional neural network model. The method comprises the following steps: building a heart disease risk prediction model based on a deep convolutional neural network, and carrying out training, learning and testing; acquiring an electrocardiogram and a cardiogram of a user by using a wearable device; comparing the electrocardiogram and the cardiogram of the user, and identifying electrocardiogram feature points and cardiogram feature points of the specific event occurrence time of the cardiac impulse cycle; calculating a time interval value of any two feature points to obtain a plurality of feature values, and calculating a plurality of physiological indexes according to the plurality of feature values; outputting the heart disease risk probability corresponding to the physiological indexes through a DCNN model according to each input physiological index; calculating a heart disease risk comprehensive probability value of the user by adopting a formula; and judging the heart disease risk level of the user according to the heart disease risk comprehensive probability value. According to the invention,the risk probability of cardiac acute diseases of the user can be predicted in real time.

The invention discloses a health data acquisition system. The health data acquisition system comprises a health data acquisition module, a data processing module and a data transmitting module, wherein the health data acquisition module is used for acquiring vital signs of a human body in real time; the data processing module is used for comparing the vital signs of the human body which are acquired by the health data acquisition module in real time with normal vital signs; and the data transmitting module is used for transmitting information for crying for help. The health data acquisition system is simple in structure and novel in design, combines the health data acquisition module, the data processing module and the data transmitting module, integrates human body vital sign monitoring, data processing and disease crying for help, and can ensure that old people and patients with acute diseases can be helped in time when attacked by diseases, so that the chance for survival of the old people and the patients with the acute diseases, attached by the diseases, is improved.

The invention relates to a remote emergency call method. A call end and a service end are used in the method comprising the steps of 1, a trigger module of the call end emits a call signal; 2, a positioning module of the call end acquires the geographical position information of a caller; 3, a storage module of the call end extracts the identify information of the caller; 4, a main control module of the call end receives and proceeds the call signal, the geographical position information and the identify information; 5, the call signal, the geographical position information and the identify information, which are proceeded by the main control module, are sent to the service end by a wireless emitting module of the call end; and 6, the service end receives the call signal, the geographical position information and the identify information for carrying out relevant rescuing arrangement. When the caller suffers from an acute disease, the call signal can be fast sent, so a rescuer at the service end can timely know the geographical position of the caller to accurately find the caller for rescuing in time.

The invention provides an orally disintegrating tablet of oleanolic acid and its preparation process, wherein the formula of the orally disintegrating tablet includes micronized oleanolic acid, bulking agent, crumbling agent, effervescent agent, flavoring agent, lubricating agent and flow aid, and a direct tabletting process is employed. The invention realizes simple process for manufacturing, easy administration, quick disintegration or dissolution in oral cavity, quick effect, substantially increased dissolution and biological availability, thus is especially suitable for the elderly, children or patients of acute diseases with inconvenience of moving or dysphagia or inaccessibility to water.

The present invention relates to a Chinese traditional medicine for treating acute laryngopharyngitis and method for making same. In china, at the present time, there are more than 10 kinds of medicines for treating throat inflammation, but they mostly are a drug for treating a plurality of diseases and can't exhibit excellent curative effects, only release pains for patients with acute diseases, 'curing the symptoms,not the disease '. In accordance with the present invention, mulberry leaf, chrysanthemum and cicada slough used for promoting the dispersing function of the lung and relieving exterior syndrome, and silver flower and capsule of weeping forsythia used for heat clearing and detoxicating are used as the principal agents which exhibit reducing fever and detoxifcation functions. Said medicine is used for treating throat painful swelling, hoarseness, acute and subacute laryngopharyngitis symptoms caused by wind-heat, possesses the advantages of remarkable curative effects, short period of treatment, fast effect, without toxic and side effects and safe clinical usage and the like.

The invention belongs to the technical field of medicines, and relates to a novel method for preparing shiny-leaved yellowhorn total saponins from shiny-leaved yellowhorn and an application of the shiny-leaved yellowhorn total saponins. According to the method, a coarse extract of the shiny-leaved yellowhorn is directly separated and purified by a macroporous resin method to obtain shiny-leaved yellowhorn total saponins; the yield of the total saponins is over 5 percent, and the content of the total saponins in a product is over 60 percent and far higher than that in products prepared by other processes. The prepared shiny-leaved yellowhorn total saponins can be applied to preparation of medicines or health-care products for preventing and treating memory deterioration, hypophrenia and cranial nerve injury caused by neurodegenerative diseases and acute and chronic cerebral injury diseases, and can be used for treating cerebral diseases caused by alzheimer disease, acute disease and subacute stage of cerebral arterial thrombosis, vascular dementia and other ischemia and hypoxia of neurodegenerative diseases and acute and chronic cerebral injury diseases.

The invention discloses a multi-functional lap belt for help calling, life saving and life supporting, comprising a belt. The multi-functional lap belt is characterized by comprising a separable hand-hold life preserver area, a necessary life-saving articles storage area, an independently used electrical life-saving area, a multi-functional belt head and a concealed safety belt, wherein the hand-hold life preserver area, the necessary life-saving articles storage area and the multi-functional belt head are in separable integral structure, and the independently used electrical life-saving area is arranged on a belt button. When urgent situations, emergent events and the like happen or in extreme environments, a user with the multi-functional lap belt can timely deal with emergencies, call for help, support life, save life, and flee for life, thus enhancing the action capacity against accident disasters, prolonging survival time and improving saved opportunities. The invention can be applied to various fields, such as traffic accidents, fires, earthquakes, terrorist attacks, wilderness survivals, outdoor travelling, salvation for patient with acute diseases, nursing for the aged and children, individual equipment of military and police and the like, thus saving life to the greatest extent. The invention can not only satisfy functional demands, but also be designed in various fashionable appearances and styles to facilitate daily use.

The invention discloses a 3D printed radix notoginseng total saponins orally disintegrating tablet and a preparation method thereof. The preparation method comprises the steps of uniformly mixing, in percentage by weight, 10-30% of radix notoginseng total saponins, 15-35% of microcrystalline cellulose, 30-50% of mannitol, 10-15% of povidone, 0-0.5% of micropowder silica gel and 0-0.5% of a flavoring agent, and putting a mixture into a powder box; putting an adhesive into an ink box; performing modeling according to preset parameters, and importing a model to a control system of a 3D printing and fast-forming machine; outputting an instruction by the control system to print a radix notoginseng total saponins orally disintegrating tablet; and after a dispersible tablet is adhered and dried, taking out the tablet to obtain the 3D printed radix notoginseng total saponins orally disintegrating tablet. According to the 3D printed radix notoginseng total saponins orally disintegrating tablet and the preparation method, the radix notoginseng total saponins orally disintegrating tablet printed by adopting a 3DP technology has the characteristics of simple process, higher disintegrating speed, higher bio-utilization degree, more convenient taking and the like, can be disintegrated in saliva of the oral cavity, and is especially suitable for bedridden patients, apoplectic hemiplegia patients with difficulty in swallowing or old people; and the effect-taking speed is higher, the treatment requirements of acute diseases such as coronary heart diseases, angina and the like are met, and personalized drug administration and accurate treatment can be realized.

Subject matter of the present disclosure is an anti-adrenomedullin antibody or an anti-adrenomedullin antibody fragment or anti-ADM non-Ig scaffold wherein said antibody or said fragment or scaffold is a non-neutralizing antibody, antibody fragment or non-Ig scaffold, respectively. Subject matter of the present disclosure is also an anti-adrenomedullin antibody or an anti-adrenomedullin antibody fragment or anti-ADM non-Ig scaffold for use in a treatment of a chronic or acute disease wherein said antibody or fragment or scaffold is: —� an ADM stabilizing antibody or an adrenomedullin stabilizing antibody fragment or an ADM stabilizing non-Ig scaffold that enhances the t 1 / 2 half retention time of adrenomedullin in serum, blood, plasma at least 10 %, preferably at least, 50 %, more preferably >50 %, most preferably 100 % and / or —� wherein said anti-ADM antibody or an anti-adrenomedullin antibody fragment or anti-ADM non-Ig scaffold blocks the bioactivity of ADM to not more than 80 %, or not more than 50 %.

The invention discloses a 3D printing type ginkgo biloba leave extract dispersible tablet and a preparation method thereof. The preparation method includes (1), uniformly mixing, by weight, 10-30% of ginkgo biloba leave extract, 25-40% of microcrystalline cellulose, 30-50% of mannitol, 10-15% of povidone, 0-0.5% of micropowder silica gel and 0-0.5% of corrigent, and filling a powder box with the mixture of the above raw materials; (2), filling an ink cartridge with an adhesive; (3), modeling according to preset parameters, and importing into a control system of a 3D printing rapid forming machine; (4), making the control system output a command to control the 3D printing rapid forming machine to print the ginkgo biloba leave extract dispersible tablet; (5), taking out the ginkgo biloba leave extract dispersible tablet after the dispersible tablet is adhered and dried, and sweeping surrounding residual powder so as to obtain the 3D printing type ginkgo biloba leave extract dispersible tablet. The 3D printing type ginkgo biloba leave extract dispersible tablet has the advantages of simple technology, higher disintegration speed, higher bioavailability, more convenience in administration and the like, thereby being particularly suitable for the elderly and patients with swallowing difficulty; the 3D printing type ginkgo biloba leave extract dispersible tablet is quicker in action, effective rapidly and capable of meeting the treatment requirements of acute diseases such as the coronary heart disease and the angina pectoris and can achieve individualized administration and precise treatment.

A health management system comprises a health wristband and a processing module, wherein the health wristband is worn on a wrist of a user and used for acquiring user's physiological parameters and storing user's personal information; and the processing module is used for receiving the user's physiological parameters acquired by the health wristband, comparing the acquired user's physiological parameters with corresponding health indexes, judging whether the user is in a healthy, sub-healthy or ill condition according to the comparison result, and sending the analysis result to the mobile phone of a contact person appointed by the user according to the user's personal information stored in the health wristband of the user. The health management system can monitor in real time and learn about the health condition of the user at the first moment; and by adoption of the health management system, children can particularly monitor the physical conditions of the aged with acute diseases, of older ages or with poor physical condition in real time even in remote places, so that the body health of the user is better guaranteed.

A method is described for predicting incipient diabetes, metabolic disorders or the metabolic syndrome by developing a personal temporal Phosphatase profile, which is generated by measuring phosphatase concentration in stool at a single time-point or multiple time-points. The phosphatase profile further can be used for diagnosing and determining prognosis of other incipient or overt diseases, such as the metabolic syndrome, coronary heart disease, nonalcoholic fatty liver disease, cancers, other chronic or acute diseases or infectious diseases. Also described is a specific dose of phosphatase for therapeutic use in incipient diabetes and other incipient or overt diseases.

The invention discloses an intelligent terminal based emergency disease coping method. The method includes: a user installs an acute disease rescue APP to store personal information of the user and a plurality of contact ways of institutions and individuals associated with the user; the user dials a well-known rescue number to automatically start the acute disease rescue APP or the user directly starts the acute disease rescue APP; the acute disease rescue APP with a misoperation preventing measure and a page allowing the user to report disease conditions confirms and calls for help to a dedicated server; the dedicated server judges importance, urgency, rescue distance and association according to calling information, intelligently calls for help to intelligent terminals or fixed telephones of the institutions and the individuals and guides emergency measures aiming at symptoms. Functions of 'one-key calling for help' and scanning for help calling are realized, and rescue measures aiming at the symptoms are realized under multi-media guidance. The intelligent terminal based emergency disease coping method is an important technology for applying the intelligent terminal to rescue of emergency patients and can be applied widely.

The invention discloses a massager which comprises a main shell, a belt and a retractable massaging device arranged in the main shell. The retractable massaging device is composed of a power device, a transmission device and a massaging head. The transmission device comprises a spiral transmission mechanism, an eccentric wheel transmission mechanism and a cam transmission mechanism. A motor is adopted as the power device. The massaging head is made of rubber. The massager can act on acupuncture points in muscle depths of the waist and back, shoulders, four limbs and the like and is simple in structure and portable, a patient can wear the massager for daily massage and health care, and the massager can be used for first aid when the patient has no strength to press the acupuncture points during acute disease outbreak.

The invention discloses 3DP (three-dimensional printed) hawthorn leaf flavonoid dispersible tablets and a preparation method for the same. The dispersible tablets are prepared from the following components in percentage by weight: 10 to 30 percent of hawthorn leaf flavonoids, 55 to 80 percent of microcrystalline cellulose, 10 to 15 percent of povidone, 0.1 to 0.5 percent of aerosil and 0 to 0.5 percent of a flavoring agent. Compared with conventional compressed Yixintong dispersible tablets, the hawthorn leaf flavonoid dispersible tablets printed by a 3DP technology have the characteristics of higher disintegration speed, higher bioavailability, more convenience for administration and the like, are particularly suitable for patients with swallowing difficulties, and can work faster to meet treatment requirements of acute diseases such as angina pectoris and cerebral ischemia. Moreover, compared with the prior art, the 3DP technology has the advantages that dosages suitable for the patients can be customized to realize personalized medication and accurate treatment according to individual differences of the patients and degrees of symptoms, so that tablets taken by the patients are reduced, maximum curative effects of the tablets are achieved, and the toxic or side effects of the tablets are maximally reduced.

The invention discloses a first-aid could system which combines a cloud data network with actual first-aid tools and can provide first aid service for the diseased suffering from a sudden heart attack or other acute diseases. The first-aid cloud system comprises multiple first aid cabinets (1) and a network cloud console, the first-aid cabinets (1) are uniformly distributed in a community, and each first-aid cabinet (1) is internally provided with a wireless location module and a first aid device, wherein the wireless location module is connected with the network cloud console through a wireless signal. The first-aid cloud system is suitable for the field of emergency medical rescue instruments.

The present invention discloses a gastrodia elata chewing gum agent, a preparation method and a detection method thereof. The gastrodia elata chewing gum agent comprises: 12-20% of gastrodia elata powder, 12-20% of food-grade gum base, 0.5-1% of essence, 20-30% of a wetting agent, 30-50% of a sweeting agent. The gastrodia elata chewing gum agent provided by the present invention has advantages ofrapid onset, easy taking, easy carrying and storing due to small volume, unsusceptibility of microbial contamination due to small water content, xerostomia eliminating, light side effect and good release rate. The preparation method for the gum agent is easy to be operated. The prepared gastrodia elata chewing gum agent with the function of rapid drug release provides good application prospects for treating headache, migraine and other acute diseases. The invention further discloses the detection method for product quality control of the gastrodia elata chewing gum agent.

The invention discloses the application of a medicinal composition in the preparation of autoimmune disease treatment medicaments, which belongs to the field of medicine. The medicinal composition is prepared from honeysuckle, baical skullcap root, fineleaf schizonepeta herb, fried cape jasmine fruit, fructus forsythiae, figwort root, ginger bombyx batryticatus, rehmannia root, blackberrykiky rhizome, platycodon root, mint, cicada slough, divaricate saposhnikovia root and licorice root. The medicaments prepared from the medicinal composition of the invention have remarkable effect on the following acute diseases: multiple sclerosis, diabetes mellitus, different cardiovascular diseases, autoimmune diseases, and the first change of different cancers.

The invention relates to a traditional Chinese medicine composition for treating child virus diarrhea. The traditional Chinese medicine composition comprises nine kinds of medicines including fried coptis chinensis, fried honeysuckle flowers, lotus leaves, coats of hyacinth beans, smoked plum, fried pomegranate bark, raw liquorice, Chinese yam and roasted malt. The traditional Chinese medicine composition gives consideration to both symptoms and root causes, has the effects of nourishing yin to benefitting spleen and elevating clear qi to lower turbid qi, is good in clinical application effect, has no untoward effect, can shorten the courses of diseases, has the rapid antidiarrheic effect, further can prevent the states of the diseases from being further developed and prompt recovery of the spleen and stomach functions; severe acute disease toxicity diarrhea occurrence rate is lowered; the sick child compliance is good; the price is reasonable; and as for numerous toxicity diarrhea sick children, the traditional Chinese medicine composition has the considerable market potential and social benefits.

The invention relates to an injection for treating acute diseases of respiratory system infection, wherein each dosage unit contains scutellaria root glycosides 60-100mg, cape jasmine glycosides 30-50mg, right amount of auxiliary and water for injection. The invention also relates to the process for preparing the injection.

The invention provides a marrow cavity puncture bag with a guide positioning mark. The bag comprises an aseptic packing bag, an aseptic hole towel and pre-operation aseptic gloves. A round hole is formed in the aseptic hole towel. The periphery of the round hole is provided with circular ring sheet. A sterilized cotton layer is arranged in the ring sheet. The lower surface of the aseptic hole towel is a waterproof layer. The upper portion of the ring sheet is provided with a waterproof layer. A horizontal marking line and a vertical marking line are arranged on the aseptic hole towel. The horizontal marking line is used for aligning with the lower border of patella of the human body. The vertical marking line is used for aligning with the tibial tuberosity of the human body. The marrow cavity puncture bag combines the positioning and sterilization of the puncture part. After the aseptic packing bag is opened, the bag can be used, and the success rate of puncturing the marrow cavity is hugely increased, the time used for puncturing the marrow cavity is also shortened, thus precious rescue time is saved for the patients of patients of critical emergency conditions suffering from the clinical acute diseases such as cardiopulmonary resuscitation, shock, massive hemorrhage and the like. The marrow cavity puncture bag with guide positioning mark is a light, convenient and practical technique, and can provide safe and convenient operation for the rescue in the battlefield and areas inflicted by disaster, pre-hospital emergency rescue and hospital emergency treatment. The 'life road' is founded.

The invention discloses an acute disease emergency medical service system for solitary elderly people. The acute disease emergency medical service system for the solitary elderly people is characterized in that a help calling signal transmitting device is worn on the arm of the elderly people in a sleeving way. A help calling signal receiving and amplification and code identification processing unit is connected with a solitary elderly people comprehensive information electronic file center. The solitary elderly people comprehensive information electronic file center is connected with a comprehensive information classification transmitting unit. The comprehensive information classification transmitting unit is respectively connected with a solitary elderly people name, gender, age, address, house number and door key password and health condition information display unit which is arranged in the 120 emergency center, a solitary elderly people health condition information display unit which is arranged in the hospital, a solitary elderly people telephone calling unit and a solitary elderly people child or relative and friend telephone calling unit.

The invention provides an acute disease occurrence probability assessment method based on ODE and GRUD and aims to solve the technical problem of low evaluation accuracy due to the fact that clinical index missing of time sequence data and non-uniform time intervals of sampling are not considered at the same time in the prior art. The method comprises the following implementation steps of: acquiring a time sequence data set, a timestamp sequence set and an acute disease tag set of multiple clinical indexes; obtaining an information attenuation characterization training sample set, an information attenuation characterization verification set sample and an information attenuation characterization test sample set; constructing a gating recursive unit network based on the ODE and the GRUD; performing iterative training on the gated recursive unit network based on the ODE and the GRUD; and obtaining an evaluation result of the occurrence probability of an acute disease. According to the method, the clinical index missing of the time sequence data and the non-uniform time intervals of the sampling can be solved, the influence of the clinical index missing is brought into a hidden state updating process, and the accuracy of the occurrence probability estimation of the acute disease is improved.

The invention provides an intelligent early warning pillow based on respiration and heart rate, a method, an electronic device and a medium. The intelligent early warning pillow comprises a pillow main body and a monitoring and early warning system, wherein the monitoring and early warning system comprises a respiratory rate sensing device, a heartbeat frequency sensing device and an early warningdevice. The respiratory rate sensing device and the heartbeat frequency sensing device are arranged in the pillow main body; the early warning device monitors the respiratory rate of a human body inreal time through the respiratory rate sensing device, monitors the heartbeat frequency of the human body in real time through the heartbeat frequency sensing device, judges the current physical condition of the human body according to the respiratory rate and heartbeat frequency of the human body and sends out a corresponding prompt signal according to the current physical condition of the humanbody. Therefore, the acute disease causing obvious changes of the respiratory rate and the heartbeat frequency can be warned in time, and more time is gained for disease treatment. The intelligent early warning pillow is particularly suitable for old people or people easily inducing acute diseases.