Cape jasmine and baikal skullcap root di-glycocide injection and its preparation process and purposes

Abstract

The invention relates to an injection for treating acute diseases of respiratory system infection, wherein each dosage unit contains scutellaria root glycosides 60-100mg, cape jasmine glycosides 30-50mg, right amount of auxiliary and water for injection. The invention also relates to the process for preparing the injection.

Description

technical field [0001] The present invention relates to a traditional Chinese medicine compound effective part injection for treating acute respiratory infection diseases, in particular extracting effective parts baicalin and total glycosides of gardenia from a prescription composed of traditional Chinese medicine Scutellaria baicalensis and Gardenia jasminoides, and then compounding them in an appropriate proportion. The genigoside injection for intravenous injection, and the present invention also relates to a method for preparing the genigoside injection and a pharmaceutical use thereof. Background technique [0002] Acute respiratory infection is the most common disease in clinical practice, including respiratory tract and lung infection, etc. It usually has an acute onset, and if it is not controlled quickly, it will often cause more serious body damage. In clinical practice, antibacterial, antiviral and For antipyretic treatment, the harm caused by the abuse of antibio...

AI Technical Summary

Problems solved by technology

Lu Maoping reported that ethanol extraction and macroporous resin purification treatment can separate iridoid components such as geniposide, but this process cannot make the purity of total geniposide in the extract reach more than 80%. At the same time, Because gardenia contains a large amount of pigments, our experimental research has proved that directly applying the gardenia ethanol extract to the macroporous resin column will cause resin pollution and regeneration difficulties; The gardenia total glycosides composition disclosed in "Preparation Method" first adopts the macroporous resin process similar to the aforementioned literature, and then is treated with a neutral alumina column. Although the purity can be improved, the problem of resin regeneration is not solved, and the oxidized The feasibility of the aluminum column purification process in industrial production is poor, and it is difficult to produce on a large scale; The same problem, and to obtain an extract with a geniposide content of 80%, it must be further purified by n-butanol or ethyl acetate or by silica gel column or alumina column chromatography, and the industrial production cost is relatively high

The water decoction or alcohol extraction process disclosed in "Gardenia iridoids total extract and its preparation method and use" by Fan Cuisheng et al. is difficult to meet the requirement that the content of effective parts exceeds 80%

[0004] Traditional Chinese medicine pays attention to the compatibility of prescriptions and the synergistic effect of drugs. The composition and dosage of medicinal flavors in prescriptions have a greater impact on its efficacy, but there are few researches on the compatibility of active components in modern preparations.

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