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Flexible vitaminc A acid liposome and its product

A flexible liposome and retinoic acid technology, which is applied in the direction of liposome delivery, anhydride/acid/halide active ingredients, etc., can solve the problems of patients with erythema, desquamation, and limit wide application, and achieve good transdermal effect, Enhanced antioxidant capacity and reduced side effects

Inactive Publication Date: 2002-09-18
刘建平 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are a variety of retinoic acid preparations clinically, their wide application in the clinic is limited because they fail to solve the transdermal problem well. In Chinese patent 97120956.1 "containing retinoic acid and clindamycin for the treatment of acne Azone with a concentration of 0.5%-2% was added as an epidermal penetration enhancer in the "composition", which improved the skin penetration performance and significantly improved the therapeutic effect, but some patients still had side effects of erythema and desquamation

Method used

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Embodiment Construction

[0009] The invention relates to retinoic acid flexible liposome and its preparation. According to retinoic acid, it has a therapeutic effect on various diseases, the most common is to treat various types of acne. According to the background technology, the retinoic acid directly contacts the epidermis and is prone to serious side effects, and the molecule contains more unsaturated ethylenic acid. Chain, easy to oxidize, makes medicine ineffective, so the present invention has prepared retinoic acid flexible liposome and preparation thereof, and its optimal formula of retinoic acid flexible liposome comprises lecithin 0.03631 gram, bile salt 0.0603 gram, retinoic acid 0.0332 gram , 35ml of composite solvent prepared in equal amounts of chloroform and ethanol; the preparation method is to rotate and evaporate in a constant temperature 37°C water bath to remove organic dissolved coal, then add an appropriate amount of 0.9% sodium chloride aqueous solution, and wash the membrane wi...

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PUM

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Abstract

A flexible vitamine A acid liposome for treating dermatopathy is disclosed, which contains lecithin, bile salt, vitamine A acid and solvent. Its medicine in the form of solution, cream, or ointment contains said flexible vitamine A acid liposome, anti-oxidizing agent, and solvent. Its advantages are high stability, durable action, high curative effect, and less or no by-effect.

Description

technical field [0001] The invention belongs to medicines for treating skin diseases, and in particular relates to a retinoic acid flexible liposome and a preparation thereof which can improve the treatment effect of retinoic acid on skin diseases such as acne by utilizing the good transdermal performance of the flexible liposome. Background technique [0002] Retinoic acid has a variety of therapeutic effects. Oral for the treatment of psoriasis (psoriasis), severe nodular and recalcitrant cystic hemorrhoids, granulocytosis and leukemia, precancerous lesions such as mucous membrane white spots of the cavity or cervix, as well as lichen planus, pityriasis pilaris, folliculitis and It has obvious therapeutic effect on pyoderma gangrenosum, etc.; external application of different concentrations of preparations has obvious effects on various acne, repair of dermal damage, removal of skin cracks, and exogenous skin aging. It is commonly used in the treatment of various acnes. I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/20
Inventor 刘建平薛吉沛
Owner 刘建平
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