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Flexible liposome cosmetic containing active small molecular substances and preparation method thereof

A technology of small molecular substances and flexible liposomes, which is applied in the direction of cosmetic preparations, cosmetics, dressing preparations, etc., to achieve the effect of improving the effect and resisting ultraviolet rays

Active Publication Date: 2019-05-03
深圳高尚科美生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, due to the barrier function of the stratum corneum of the skin, most of the active small molecules with functions, especially the water-soluble small molecules, are difficult to penetrate into the deep layer of the skin to play a role

Method used

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  • Flexible liposome cosmetic containing active small molecular substances and preparation method thereof
  • Flexible liposome cosmetic containing active small molecular substances and preparation method thereof
  • Flexible liposome cosmetic containing active small molecular substances and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Embodiment 1 Preparation of flexible liposomes containing active small molecular substances of the present invention

[0066] The preparation technology of the flexible liposome containing water-soluble and fat-soluble small molecular substances is described as follows:

[0067] 1) Flexible liposomes containing water-soluble small molecular substances:

[0068] Accurately weigh soybean lecithin, sodium deoxycholate or polysorbate 80 or its derivatives, vitamin E according to the formula, dissolve with a mixture of chloroform and ethanol or only ethanol, dissolve and mix in a 250ml pear-shaped bottle, and store at room temperature Rotary evaporated for 2 hours, and the resulting film was placed in a vacuum oven overnight. The next day, distilled water and appropriate amount of hydrophobically modified polypeptide DP7-C or PAL-DP7 were added, and a 400w probe was sonicated for 30 minutes to obtain a blank transfersome solution. Slowly add an appropriate amount of water-...

Embodiment 2

[0138] Example 2 Verification of the transdermal effect of the flexible liposome containing active small molecules of the present invention

[0139] The in vitro transdermal experiment adopts a modified single-chamber Franz diffusion cell, and mouse skin is used as the in vitro transdermal experimental skin to compare the transdermal absorption results of different flexible liposomes containing active small molecules, and samples are taken at different time points. The concentration of the drug in the transdermal receiving solution was determined by HPLC method, and the cumulative transdermal amount was calculated.

[0140] Test example 2-1 Verification of the transdermal effect of flexible liposomes containing nicotinamide

[0141] 1. Materials

[0142] Samples: lyophilized powder of flexible liposomes containing nicotinamide prepared in Example 1 (1-1, 1-2, 1-3, 1-4) and nicotinamide-containing liposomes not modified by DP7-C or PAL-DP7 The flexible liposome of amide is us...

Embodiment 3

[0177] Example 3 Stability study of the flexible liposome freeze-dried powder containing active small molecules of the present invention

[0178] The flexible liposome freeze-dried powder containing active small molecules prepared in Example 1 was subjected to stability research (including three aspects such as accelerated test and long-term test). The samples were placed in a drug stability test chamber at 37°C for accelerated testing, and placed for 1, 2, 3, and 6 months respectively, and the properties of the freeze-dried powder were measured, including color, content, and solubility. The results are shown in Table 7. Then put the samples in a drug stability test box at 25°C for long-term tests, and place them for 3, 6, 9, 12, 15, 18, 21, and 24 months respectively to detect the color, HPLC content, and solubility of the freeze-dried powder. The results are shown in Table 8.

[0179] The stability accelerated test (37 ℃) of table 7 lyophilized powder

[0180]

[0181] ...

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Abstract

The invention belongs to the field of cosmetics, and in particular relates to a flexible liposome cosmetic containing active small molecular substances and a preparation method thereof. Due to the barrier action of epidermal cuticle of the skin, most active ingredients in cosmetics containing active small molecular substances are difficult to penetrate the skin. In view of the above problem, the present invention provides the flexible liposome cosmetic containing active small molecular substances, a flexible liposome which contains active small molecular substances and is modified by a hydrophobic modifying polypeptide is prepared into the cosmetic so as to effectively improve the penetration rate of the active small molecular substances in the cosmetic and to developed the cosmetic with easier absorption and better anti-oxidation and anti-aging effects. The cosmetic has broad application prospects.

Description

technical field [0001] The invention belongs to the field of cosmetics, and in particular relates to a flexible liposome cosmetic containing active small molecular substances and a preparation method thereof. Background technique [0002] For a long time, skin anti-aging, whitening, anti-wrinkle and other cosmetics have been one of the best-selling and most popular products in the global market. Over the years, it has been highly valued and generally concerned by related disciplines, especially medical cosmetology, cosmetic science, skin care and skin anti-aging. At present, a wide variety of skin cosmetics with various dosage forms have been developed. In fact, the main functional ingredients in these skin cosmetics are mostly active small molecule substances, including skin moisturizers (such as hyaluronic acid, hyaluronan, chitosan, etc.), skin barrier repair agents (such as ceramides, phospholipids, etc.) , cholesterol, etc.), skin nutrients (such as amino acids, polysa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/64A61K8/63A61K8/55A61K8/49A61K8/67A61K8/35A61K8/68A61K8/60A61K8/44A61K8/368A61K8/34A61K8/37A61Q19/00A61Q19/02A61Q19/08A61Q17/04
Inventor 杨莉魏于全
Owner 深圳高尚科美生物科技有限公司
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