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Compound preparation for external use for treating alopecia areata and preparation method thereof

An external preparation and compound technology, applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as poor hair repair effect, reduce the risk of systemic side effects, and prolong the life of the drug. Effective, targeted effect

Inactive Publication Date: 2021-02-26
CHANGSHA JINGYI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tofacitinib inhibits the key signaling pathways in the pathogenesis of alopecia areata, making up for the lack of efficacy of minoxidil for moderate and severe patients from the etiology; at the same time, through the good hair growth promoting effect of minoxidil, it improves the symptoms of Tofacitinib Insufficient effect of Fatinib on hair restoration

Method used

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  • Compound preparation for external use for treating alopecia areata and preparation method thereof
  • Compound preparation for external use for treating alopecia areata and preparation method thereof
  • Compound preparation for external use for treating alopecia areata and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] (1) Prescription

[0054]

[0055] (2) Preparation method

[0056] In the preparation container, add the prescribed amount of purified water, PEG 400 and propylene glycol, and stir evenly to form a mixed solvent. While stirring, slowly add Tween 80, sodium lauryl sulfate, tofacitinib, minoxidil, glycerin, polyvinylpyrrolidone, xanthan gum, cetyl alcohol in the prescribed amount, and then use a homogenizer to homogenize chemical or sonication. The prepared pre-foaming mixture is filled in a pressurized container tank and filled with tetrafluoroethane to obtain the product.

Embodiment 2

[0058] (1) Prescription

[0059]

[0060] (2) Preparation method

[0061] In the preparation container, add the prescribed amount of purified water, PEG 400 and ethanol, and stir evenly to form a mixed solvent. Slowly add the prescribed amount of Tween 80, sodium fatty alcohol polyoxyethylene ether sulfate, tofacitinib, minoxidil, glycerin, hypromellose, carbomer, stearyl alcohol while stirring, and then use Homogenize or ultrasonically dissolve. Put the prepared pre-foaming mixture into a hand-pressed net-type foam lotion pump bottle to get ready.

Embodiment 3

[0063] (1) Prescription

[0064]

[0065] (2) Preparation method

[0066] Preparation of aqueous phase mixture: Add the prescribed amount of xanthan gum, polyvinylpyrrolidone, sodium lauryl sulfate, Tween 80, glycerin, etc. into the mixed solvent of water and polyethylene glycol 400 while stirring, and heat to 50~ Dissolve at 70°C;

[0067] Preparation of oil phase mixture: Heat soybean oil, coconut oil, and isopropyl myristate to the same temperature as the water phase, and add prescribed amounts of cetyl alcohol, stearyl alcohol, tofacitinib, and minoxidil while stirring , to make it dissolve;

[0068] Mixing: Slowly pour the hot oil phase into the hot water phase under stirring, emulsify with a homogenizer, and cool to room temperature;

[0069] Filling: Fill the prepared pre-foaming mixture into a pressurized container tank and fill it with tetrafluoroethane-heptafluoropropane mixture to obtain the product.

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PUM

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Abstract

The invention discloses a compound preparation for external use for treating alopecia areata and a preparation method thereof, active ingredients of the compound preparation for external use compriseA and B, the active ingredient A is one or more of a JAK (Janus kinase) inhibitor or a pharmaceutically acceptable salt thereof, and the active ingredient B is minoxidil or a pharmaceutically acceptable salt thereof, drug forms of the preparation for external use comprise emulsion, ointment, emulsifiable paste, tincture, patch, gel, liniment, foaming agent, etc., and the foaming agent is preferred. The compound preparation for external use provided by the invention can act on different targets of alopecia areata pathogenesis through the two components to play a synergetic effect, so that the curative effect on alopecia areata, especially on moderate and severe alopecia areata, is enhanced. Meanwhile, the compound preparation for external use is preferably designed to be the foaming agent with a light texture to be easily and evenly distributed on scalp, so as to improve the applicability to hair parts and the compliance of patients, and solubility and permeability of active ingredientsare increased through drug form improvement, so as to prolong the effective drug duration and reduce the toxic and side effects of the active ingredients.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a compound external preparation for treating alopecia areata and a preparation method thereof. Background technique [0002] Alopecia areata is a common non-scarring hair loss disease caused by hair follicle inflammation. According to pathological features and severity, it can be divided into localized patchy alopecia areata, total alopecia and general alopecia. The global incidence rate is about 1% to 2%, and most of the patients are children and young adults. Alopecia areata affects the appearance and mental health of patients. Conventional treatment drugs (including glucocorticoids, compound glycyrrhizin, contact sensitizers, hair growth promoting agents, etc.) limitations, and therefore require the development of new therapeutic modalities. [0003] Alopecia areata is an inflammatory autoimmune disease, which is related to the destruction of hair follicl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/519A61K31/506A61K9/12A61K9/107A61K47/26A61K47/20A61P17/14
CPCA61K45/06A61K31/519A61K31/506A61K9/122A61K9/124A61K9/107A61K9/0014A61K47/26A61K47/20A61P17/14A61K2300/00A61K47/10A61K9/06
Inventor 张海龙王芮
Owner CHANGSHA JINGYI PHARM TECH CO LTD
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