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Two-phase drug-release multilayer drug-loaded nanofiber mat and preparation method thereof

A drug-loaded nano-fiber mat technology, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, antipyretics, etc., can solve problems such as low safety, low encapsulation efficiency, and complicated technology, and achieves the goal of preparation methods Simple, easy-to-operate, easy-to-carry effect

Inactive Publication Date: 2012-12-19
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nano-polymer liquid crystal systems, hydrogel drug delivery systems, and nanoparticles prepared by solvent self-emulsification diffusion technology have been developed. They can achieve two-phase drug release, but they have low encapsulation efficiency, low safety, and high cost. High and technically complex issues

Method used

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  • Two-phase drug-release multilayer drug-loaded nanofiber mat and preparation method thereof
  • Two-phase drug-release multilayer drug-loaded nanofiber mat and preparation method thereof
  • Two-phase drug-release multilayer drug-loaded nanofiber mat and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Preparation of coaxial structure 1

[0038] (1) Preparation of spinning dope: Suspend 0.875g of ketoprofen in 10mL of absolute ethanol containing 3.5g of polyvinylpyrrolidone PVP K30, stir mechanically (12h) and continue heating (50±1°C, 8h), and prepare Spinning stock solution 1; suspend 0.6g ketoprofen in 10mL absolute ethanol containing 2.4g ethyl cellulose, mechanically stir (12h) and continue heating (50±1°C, 8h) to prepare spinning stock solution 2;

[0039] (2) Preparation of coaxial structure 1: Pour the prepared spinning stock solutions 1 and 2 into the solution reservoirs 1 and 2 (5mL syringes) respectively, connect the flattened No. 7 injection needles, and then connect the two needles to On the coaxial device (the polyvinylpyrrolidone spinning solution is the outer layer, and the ethyl cellulose spinning solution is the inner layer), the device is connected to the positive pole of the high-voltage power supply, and the aluminum foil fiber receiving plate wi...

Embodiment 2

[0041] Preparation of coaxial structures 2

[0042] (1) Preparation of spinning dope: Suspend 0.875g of ketoprofen in 10mL of absolute ethanol containing 3.5g of polyvinylpyrrolidone PVP K30, stir mechanically (12h) and continue heating (50±1°C, 8h), and prepare Spinning stock solution 1; suspend 0.6g ketoprofen in 10mL absolute ethanol containing 2.4g ethyl cellulose, mechanically stir (12h) and continue heating (50±1°C, 8h) to prepare spinning stock solution 2;

[0043] (2) Preparation of coaxial structure 2: Pour the prepared spinning stock solutions 1 and 2 into the solution reservoirs 1 and 2 (5mL syringes) respectively, connect the flattened No. 7 injection needles, and then connect the two needles to the On the coaxial device (the ethyl cellulose spinning solution is the outer layer, and the polyvinylpyrrolidone spinning solution is the inner layer), the device is connected to the positive pole of the high-voltage power supply, and the aluminum foil fiber receiving pla...

Embodiment 3

[0045] Preparation of multi-layer coaxial drug-loaded fiber mats

[0046] (1) Preparation of spinning dope: Suspend 0.875g of ketoprofen in 10mL of absolute ethanol containing 3.5g of polyvinylpyrrolidone PVPK30, stir mechanically (12h) and continue heating (50±1°C, 8h) to prepare Spinning stock solution 1; suspend 0.6g ketoprofen in 10mL absolute ethanol containing 2.4g ethyl cellulose, mechanically stir (12h) and continue heating (50±1°C, 8h) to make spinning stock solution 2;

[0047] (2) Preparation of multi-layer coaxial structure drug-loaded fiber mat:

[0048] Electrospinning of coaxial structure 1 (first and second layer electrospinning): Pour the above-mentioned prepared spinning stock solutions 1 and 2 into solution reservoirs 1 and 2 (5mL syringes), respectively, and connect the flattened No. 7 injection Needles, two needles are connected to the coaxial device (polyvinylpyrrolidone spinning solution is the outer layer, ethyl cellulose spinning solution is the inne...

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Abstract

The invention relates to a two-phase drug-release multilayer drug-loaded nanofiber mat and a preparation method thereof. The fiber mat is a multilayer drug-loaded nanofiber membrane which consists of a water-soluble polymer, a water-insoluble polymer and a drug. The nanofiber membrane has the following two structures: a shell layer is the drug-contained water-soluble polymer, and a core layer is the drug-contained water-insoluble polymer; the shell layer is the drug-contained water-insoluble polymer, and the core layer is the drug-contained water-insoluble polymer. A preparation method for a nano analgesic comprises the following steps of: (1) preparing spinning solution containing analgesic ketoprofen; (2) preparing a multilayer nanofiber membrane through performing coaxial electrostatic spinning on the prepared spinning solution, and drying to obtain the drug-loaded nano analgesic. The nano analgesic can be used for rapidly and durably easing pains, can be easily carried, is convenient in administration and can be used for administrating drugs into intestinal tracts in the manner of targeting. The invention has the advantages that the preparation method is simple and is low in cost, and has no special requirements on equipment; and the two-phase drug-release multilayer drug-loaded nanofiber mat can be produced on a large scale.

Description

technical field [0001] The invention belongs to the field of preparation of drug-loaded nanofiber mats, in particular to a multi-layer drug-loaded nanofiber mat for two-phase drug release and a preparation method thereof. Background technique [0002] The coaxial electrospinning technology is developed on the basis of electrospinning. The main improvement measure is to improve the spinneret into a concentric composite capillary, which solves the limitations of the traditional electrospinning method, namely: the two When blending two or more raw materials, the mixing system must be uniform. This new processing method is easy to operate and the fibers prepared by this technology are better than other processing methods in terms of uniformity and continuity. The core-shell composite nanofibers prepared by coaxial electrospinning technology can make up for the shortcoming of simple mixed spinning of drugs and carrier materials, and have good application prospects in the field o...

Claims

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Application Information

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IPC IPC(8): A61K47/30A61K47/38A61K47/32A61K9/00A61P29/00
Inventor 朱利民黄丽娅
Owner DONGHUA UNIV
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