The invention relates to a multivitamin preparation and a preparation method of the multivitamin preparation. The multivitamin preparation is a dietary supplement for supplementing multivitamin and multiple mineral substances needed by the human body and belongs to the field of health-care food. The multivitamin preparation is a tablet prepared by the steps of adopting liquated polyethylene glycol as an adhesive, preparing one or more than one of donkey-hide gelatin extractive, red date extractive, grape seed extractive and multiple heme iron into particles and adding vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, folic acid, biotin, pantothenic acid, mineral substance calcium, magnesium, zinc, selenium, copper, molybdenum, manganease and the like as active ingredients. According to the invention, compared with the traditional tablet preparation method, no water is added during the particle preparation process, no high-temperature drying process is needed, and the effect of the extractive can be furthest ensured.