The invention belongs to the technical field of food and drugs, and particularly provides a health-care composition for invigorating the kidney, tonifying yang, and preserving health. The composition is mainly prepared from ginseng, sealwort, barbary wolfberry fruit, cinnamon, gorgon fruit, bitter cardamom, raspberry, gingko, Maca, eucommia ulmoides male flowers, mulberries, yams, sea-buckthorn, poria cocos, honey and cordyceps flowers. The invention further provides a preparation method and application of the health-care composition for invigorating kidney, tonifying yang, and preserving health. The health-care composition for invigorating the kidney, tonifying yang, and preserving health has the advantages of accurate drug use, direct medical effect, obvious effect, low cost and the like in the aspect of treating and regulating deficiency of the kidney and a sub-health status, and can realize the regulating effects of invigorating the kidney and essence replenishment, warming the kidney and tonifying yang. According to the preparation method provided by the invention, the active ingredients of each raw material can be extracted to the maximum extent, the medical effect of a product can be guaranteed, and the preparation method is easy to realize, and suitable for industrial mass production.