Medicine for treating coronary heart disease

A coronary heart disease and composition technology, applied in the field of drugs for the treatment of coronary heart disease, can solve problems such as myocardial no-reflow and remodeling, and achieve the effect of improving the level of innovation and international competitiveness

Active Publication Date: 2011-11-02
PEKING UNIV FIRST HOSPITAL
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

Although modern medicine has made significant progress in drug intervention and interventional therapy, many clinical problems remain unsolved, such as myocardial no-reflow after reperfusion, ventricular remodeling after myocardial infarction, etc.

Method used

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  • Medicine for treating coronary heart disease

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Experimental program
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Effect test

Embodiment 1

[0018] Embodiment 1, Chinese medicine formula

[0019] 1. Animal experiment method - anti-myocardial ischemia effect:

[0020] (1) Experimental animals: 140 healthy and clean Wistar rats, weighing 180±20 g, male.

[0021] (2) Experimental drugs: 5 kinds of formula preparations of Xiyang Shenyuanhu. Its mass ratio is as follows:

[0022] American ginseng decoction pieces were purchased from Guangzhou Kangmei Pharmaceutical Co., Ltd., the product catalog number is 20101205, and the average content of its active ingredients (ie total saponins of American ginseng) is 4.30%.

[0023] Corydalis Corydalis sliced ​​with vinegar was purchased from Beijing Weiren Traditional Chinese Medicine Decoction Pieces Factory, the product catalog number is 103209201, and the average content of its active ingredient (ie, Corydalis Corydalis) is 0.105%.

[0024] American ginseng decoction pieces: vinegar-roasted Corydalis Corydalis = 2:1, that is, the active ingredient in American ginseng decoct...

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Abstract

The invention discloses a medicine for treating coronary heart disease. In the product of the invention for preventing and / or treating coronary heart disease, the active ingredients thereof are composed of panax quinquefolium saponin and tetrahydropalmatine. The experiment proves that compatible American ginseng and rhizoma corydalis can be used for efficiently treating myocardial ischemia; therefore, American ginseng and rhizoma corydalis can be used for preventing and / or treating coronary heart disease. The technique method for preparing the alkaloidal compatible preparation of panax quinquefolium saponin and rhizoma corydalis is stable, the extraction rate of active ingredients is high, and the medicine is suitable for industrial production. The medicine of the invention establishes a technical platform for the research and development of innovative traditional Chinese medicines for coronary heart disease in the aspects of the safety, efficacy evaluation, pharmacokinetics and the like of compound traditional Chinese medicine, which is good for developing new traditional Chinese medicines with good clinical application prospect and market competitiveness, and further increases the innovation level and international competitiveness of new domestic medicines.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a medicine for treating coronary heart disease. Background technique [0002] Coronary heart disease is a major disease that seriously threatens human health and life. Its morbidity and mortality are increasing year by year, which has brought a heavy medical burden to the society. It is a major public health problem in our country. Therefore, the prevention and treatment of coronary heart disease is very important. important. Although modern medicine has made significant progress in drug intervention and interventional therapy, many clinical problems remain unsolved, such as myocardial no-reflow after reperfusion and ventricular remodeling after myocardial infarction. Traditional Chinese medicine has many therapeutic principles and clinical effectiveness, such as replenishing qi and activating blood circulation, removing blood stasis and promoting regeneration, and ha...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P9/10A61K31/4375
Inventor 刘梅林
Owner PEKING UNIV FIRST HOSPITAL
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