33 results about "Anticholinesterase Agents" patented technology

The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to pyrrole alkaloid compounds extracted, separated and identified from purslane and an extraction and separation method thereof. Described pyrrole alkaloid compound, molecular formula is C 16 H 9 NO 4 , and named 10,11‑dihydroxybenzo[5',6']pentaleno[1',2':3,4]pyrrolo[2,1‑b]oxazol‑7(11bH)‑one according to its structure. Also provided is an extraction and separation method for the above-mentioned pyrrole alkaloid compound, which is prepared by successively adopting ethanol reflux extraction, silica gel column chromatography, ODS medium pressure column and hydroxypropyl dextran column chromatography purification, and liquid phase separation. Its structure adopts 1 H-NMR, 13 The method of C-NMR and UHPLC-ESI-TOF-MS was determined to be a pyrrole alkaloid compound. The compound has potential activities such as anti-inflammatory and anticholinesterase, and provides a preparation method, which provides a lead and theoretical basis for the development of new drugs and new components.

The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to three alkaloid compounds extracted, separated and identified from purslane and an extraction and separation method thereof. Described three kinds of alkaloid compounds, molecular formula is respectively C 16 h 15 NO 5 , C 13 h 11 NO 3 , C 14 h 13 NO 3 , named as 4,9,10-trihydroxy-2-methoxy-6,7-dihydrodibenzo[b,e]azocin-12(5H)-one, 9,10-dihydroxy-5,6-dihydro-11H-benzo [d]pyrrolo[1,2‑a]azepin‑11‑one, 8,9‑dihydroxy‑6,11‑dihydro‑5H‑benzo[d]pyrrolo[1,2‑a]azepine‑3‑carbaldehyde. It also provides an extraction and separation method for the above-mentioned alkaloid compounds, which is sequentially prepared by ethanol reflux extraction, silica gel column chromatography, ODS medium pressure column and hydroxypropyl dextran column chromatography, and HPLC separation and preparation. Its structure adopts 1 H-NMR, 13 C-NMR and UHPLC-ESI-TOF-MS methods identified three new alkaloid compounds. The three compounds have potential anti-inflammatory and anti-cholinesterase activities, and provide preparation methods to provide lead and theoretical basis for the development of new drugs and new ingredients.

This invention concerns a dosage form comprising a therapeutically effective amount of A19-144 or A2-73 and a therapeutically effective amount of at least one AED. This invention further encompasses a method of treating a subject in need of such treatment comprising administering a therapeutically effective amount of A19-144 or A2-73 in conjunction with an therapeutically effective amount of an AED.

The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to pyrrole dicarboxylic acid compounds extracted, separated and identified from purslane and an extraction and separation method thereof. Described pyrrole dicarboxylic acid compound, molecular formula is C 7 h 8 N 2 o 5 , named 3‑(carboxy(methoxy)amino)‑1H‑pyrrole‑2‑carboxylic acid. Also provided is an extraction and separation method for the above-mentioned pyrrole dicarboxylic acid compound, which is prepared by decocting in water, ethyl acetate extraction, silica gel column chromatography, ODS medium pressure column, Sephadex LH‑20 purification, and liquid phase separation. Its structure adopts 1 H NMR, 13 C NMR and two-dimensional NMR spectral analysis method identified as a new pyrrole dicarboxylic acid compound. The compound has potential anti-inflammatory and anti-cholinesterase activities, and provides a preparation method to provide a lead and a theoretical basis for the development of new drugs and new components.

The invention discloses a preparation and application of macleyine and other medicine preparation extract from plants, its character lies in: it extracts macleyine with purity of 98% from bloodroot, and part of barberry family and buckthorn plants, and produces solid preparation, injection preparation compound with medicine accessories, the product can be used for curing heart and brain vessel diseases, and AD sufferer, at the same time, the product also has functions of analgesia, anticholinesterase functions and it can advances the bile secretion, and so on.