Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pyrrole dicarboxylic acid compound in herba portulacae and extraction and separation method and application thereof

A technology of pyrrole dicarboxylic acid and separation method, which is applied in the field of pyrrole dicarboxylic acid compounds and their extraction and separation, can solve the problems of low structural novelty and the like, and achieves the effects of environmental protection of the process method, simple and fast operation method

Active Publication Date: 2019-09-24
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
View PDF3 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pyrrole dicarboxylic acid compound in herba portulacae and extraction and separation method and application thereof
  • Pyrrole dicarboxylic acid compound in herba portulacae and extraction and separation method and application thereof
  • Pyrrole dicarboxylic acid compound in herba portulacae and extraction and separation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The invention provides a kind of pyrrole dicarboxylic acid compound, molecular formula is C 7 h 8 N 2 o 5 , named 3-(carboxy(methoxy)amino)-1H-pyrrole-2-carboxylic acid, the chemical structure is.

[0030]

[0031] The pyrrole dicarboxylic acid compound is named 3-(carboxy(methoxy)amino)-1H-pyrrole-2-carboxylic acid according to the structure, and Table 1 is the NMR data of the pyrrole dicarboxylic acid compound: 1 H-NMR with 13 C-NMR in DMSO.

[0032] Table 1 NMR data of pyrrole dicarboxylic acid compound 3-(carboxy(methoxy)amino)-1H-pyrrole-2-carboxylic acid of the present invention

[0033] Numbering δC type δH,mult(J in Hz) 1 NH 2 124.81 C 3 147.74 C 4 113.95 CH 6.66(1H,d,3.30) 5 115.25 CH 6.78(1H,d,3.84) 6 161.60 C 7 N 8 160.35 C 9 O 10 51.36 CH 3

3.77(3H)

[0034] The invention discloses a structure identification and deduction of a pyrrole dicarb...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
degree of unsaturationaaaaaaaaaa
Login to View More

Abstract

The invention relates to the field of extraction and separation of traditional Chinese medicine, in particular to a pyrrole dicarboxylic acid compound extracted, separated and identified from herba portulacae and an extraction and separation method thereof. The molecular formula of the pyrrole dicarboxylic acid compound is C7H8N2O5, and the pyrrole dicarboxylic acid compound is named as 3-(carboxy(methoxy)amino)-1H-pyrrole-2-carboxylic acid. The extraction and separation method of the pyrrole dicarboxylic acid compound is further provided. The compound is prepared by sequentially adopting water for decoction extraction, ethyl acetate for extraction, a silica gel column for chromatography, an ODS medium pressure column and Sephadex LH-20 for purification and a liquid phase for separation. The novel pyrrole dicarboxylic acid compound is structurally determined by means of an approach including 1H NMR, 13C NMR and two-dimensional NMR wave spectrum analysis. The compound has potential activity such as inflammation resistance and cholinesterase resistance, a preparation method is provided, and a leading compound and a theoretical basis are provided for development of new drugs and new components.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a pyrrole dicarboxylic acid compound extracted, separated and identified from purslane medicinal material and an extraction and separation method thereof. Background technique [0002] Purslane (Portulaca oleracea L.), also known as longevity dish, horse amaranth, is a plant of the family Amaranthaceae. Purslane likes fertile soil, is resistant to drought and waterlogging, has strong vitality, is widely distributed, and is rich in resources, and it is more common in Northeast my country. Purslane can be used as both medicine and food, and it is one of the wild plants with the same origin of medicine and food designated by the Ministry of Health of my country. The 2015 edition of "The Pharmacopoeia of the People's Republic of China" records that the dried aerial part of purslane is used as medicine. It has the effects of clearing away heat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D207/34A61P29/00A61P25/28A61P11/06A61P27/02
CPCC07D207/34A61P29/00A61P25/28A61P11/06A61P27/02
Inventor 英锡相崔馨予张文洁
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com