Direct oral decumbent corydalis tuber powder Chinese herbal piece
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A Chinese medicine decoction piece, direct technology, applied in the field of medicine, can solve the problems of nuclear material residue, different quality, no data, etc.
Pending Publication Date: 2017-09-15
江苏苏轩堂药业有限公司
View PDF3 Cites 2 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Physical sterilization methods such as dry heat, high temperature and high pressure steam, chemical sterilization methods such as ethylene oxide, and gamma ray sterilization methods such as cobalt-60 all have major defects, and some of the sterilization methods have poor sterilization effects. Some destroy and partially change the chemical properties of active ingredients of different structural types contained in traditional Chinese medicines of different textures, some leave nuclear substance residues, and some have pollution factors, etc.
[0009] Direct oral Chinese herbal decoction pieces are a new type of modern Chinese herbal decoction pieces that have just been defined by the state in recent years. In addition to the microbial limit standards for direct ...
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
preparation example Construction
[0059] Preparation of the reference substance solution Take 10 mg of the original opioid reference substance, accurately weigh it, and place it in a 50ml measuring flask. Add 5ml of 1% hydrochloric acid solution to dissolve it, then add methanol to the mark and shake it up. Take another 10mg of palmatine hydrochloride reference substance, accurately weigh it, put it in a 100ml measuring flask, add methanol to dissolve and dilute to the mark, and shake well. Accurately measure 5ml of each of the above two solutions, place them in the same 25ml measuring flask, add methanol to the mark, and shake well to obtain (each lml contains 40ug of original opioid and 20ug of palmatine hydrochloride).
[0060] Preparation of the test solution: Take about 0.5g of the fine powder of this product, accurately weigh it, place it in a stoppered conical flask, accurately add 50ml of methanol, weigh it, heat and reflux for 1 hour, let it cool, and then weigh it. Methanol makes up the lost weight, sha...
Embodiment 1
[0075] 120 kilograms of summer raw medicinal materials, divided into 3 experimental batches (40.0 kilograms per batch), according to the drug GMP specifications, respectively, after purification, drying, and crushing (Class D clean area, application of vacuum low-temperature crushing technology, crushing separately 100, 150, 200-300 mesh), intermediates (inspection), quantitative packaging (6 g / bag, Class D clean area), electron beam irradiation sterilization (the remaining 30% of quantitative packaging in each batch will not be carried out Sterilization process), and the obtained product (test product) is used for the experimental research of the summer powder-free best GMP production process and its quality standard of the present invention.
[0076] 1. The best production process of "Xiamen Wufen" direct oral Chinese medicine decoction pieces:
[0077] (1) The best fineness (number of meshes) production process:
[0078] The size of Xiatian rhizomeless cells is ten to several ten...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention provides a direct oral decumbent corydalis tuber powder Chinese herbal piece. A preparation process of the direct oral decumbent corydalis tuber powder Chinese herbal piece is as follows: (1) after being inspected, cleaned and dried, a raw material decumbent corydalis tuber is ground, so that an intermediate is obtained; (2), the intermediate is inspected, and after the intermediate is packaged, electron beam irradiation is carried out for sterilization; (3) final product standard inspection is carried out, and after packaging, the final product is obtained. In step (1), the grinding conditions are as follows: in a grade D clean area, a dust suction type cryogenic system grinding technology is applied to grind the raw material decumbent corydalis tuber into 100 to 300 meshes; and in step (2), the exposure dose of electron beam irradiation for sterilization is 3kGy to 10kGy. The total amount of an aqueous extract of the decumbent corydalis tuber (powder) product and the total amount of water-dissolved protopine and palmatine chloride in the aqueous extract can be increased by 30 to 45 percent in comparison with the total amount of an aqueous extract of the fine powder standard (100 meshes) of Chinese Pharmacopoeia and the total amount of water-dissolved protopine and palmatine chloride in an aqueous extract, and a microbial limit test result can fully come up to a related direct oral piece standard.
Description
Technical field [0001] The invention relates to a summer powder-free direct oral Chinese medicine decoction piece, which belongs to the technical field of medicine. Background technique [0002] Summer inaction, Papaveraceae Corydalis perennial herb Corydalis decumbens Corydalis decumbens [0003] (Thunb.) The dry tuber of Pers., also known as Fudiyanhusuo, Fudiyuanhu, Viola sessile, Xia Wuzong. Xiawuwu completes the life process of flowering and fruiting before the arrival of early summer, and then begins the withering of the whole plant. When the summer heat comes, there will be no plants for Xiawuwu on the ground, hence the name "Xiamenwu" [0004] Xiatianwu is a common Chinese medicinal material. It is warm in nature and pungent in taste. It has the effect of activating blood and relieving pain. It has healing effect on the treatment of congestion, redness, joint pain, bruises and rheumatoid. Moreover, the alkaloids contained in Tianwuwu have a therapeutic effect on cardiovascu...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more 
Login to view more