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Ginseng-based whitening and anti-aging nanoemulsion essence and preparation method thereof

A nano-emulsion and essence technology, which is applied in pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of difficult whitening and anti-aging effects of ginseng, discounts on ginseng efficacy, and low technical content, and achieves water-resistant dilution. The effect of good ability, good thermodynamic stability and simple process

Inactive Publication Date: 2013-12-25
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the commercially available cosmetics containing ginseng ingredients include "Dingjiayi Ginseng Whitening Cream", which only contains ginseng ingredients in common dosage forms; while the imported cosmetics approved by the State Food and Drug Administration include South Korea, North Korea, Taiwan, Hong Kong, Thailand, France, The series of cosmetics containing ginseng ingredients in Britain and the United States are still common dosage forms, but the price is very expensive. In short, the dosage forms of these cosmetics containing ginseng ingredients are mostly creams, ointments and ordinary lotions, etc., with low technical content and contain a lot of added ingredients. Chemical ingredients, long-term application, will cause damage to the skin
As we all know, the functional ingredient of ginseng is ginsenoside, and ginsenoside is insoluble in water, and the drug loading in cream, ointment and ordinary emulsion is very limited. Even if penetration enhancers such as azone are added, the main component of ginseng can hardly be absorbed If it is rarely absorbed, the efficacy of ginseng will be greatly reduced due to the backwardness of the dosage form, and it is difficult to truly exert the whitening and anti-aging effect of ginseng

Method used

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  • Ginseng-based whitening and anti-aging nanoemulsion essence and preparation method thereof
  • Ginseng-based whitening and anti-aging nanoemulsion essence and preparation method thereof
  • Ginseng-based whitening and anti-aging nanoemulsion essence and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] 1) Select the oil phase, surfactant and co-surfactant by calculating the HLB value, and draw the pseudo-ternary phase diagram according to the ratio of 9:1~1:9 to determine the optimal ratio.

[0052] 2) Accurately weigh 0.4g of lecithin, 1.0g of sucrose ester, 2.5g of propylene glycol, 0.55g of olive oil, 0.19g of ginsenoside, and 6.0g of distilled water for later use.

[0053] 3) Put lecithin, sucrose ester, propylene glycol and olive oil into a beaker, stir quickly in a water bath at 25°C, then slowly add distilled water dropwise, and keep stirring until a clear and transparent light yellow solution appears. Then add ginsenoside into the system to obtain oil-in-water ginseng whitening and anti-aging nanoemulsion essence with a particle size of less than 100nm.

Embodiment 2

[0055] 1) Select the oil phase, surfactant and co-surfactant by calculating the HLB value, and draw the pseudo-ternary phase diagram according to the ratio of 9:1-1:9 to determine the optimal ratio.

[0056] 2) Accurately weigh 0.4g of lecithin, 3.0g of propylene glycol, 0.6g of rose essential oil, 0.35g of ginsenoside, and 6.0g of distilled water for later use.

[0057] 3) Add lecithin, propylene glycol and rose essential oil into a beaker, stir quickly in a water bath at 25°C, then slowly add distilled water dropwise, and keep stirring until a clear and transparent light yellow solution appears, then add ginseng Saponins are added to the system to obtain water-in-oil ginseng whitening and anti-aging nanoemulsion essence with a particle size of less than 100 nm.

Embodiment 3

[0059] 1) Select the oil phase, surfactant and co-surfactant by calculating the HLB value, and draw the pseudo-ternary phase diagram according to the ratio of 9:1-1:9 to determine the optimal ratio.

[0060] 2) Accurately weigh 0.4g lecithin, 0.5g caprylic capric macrogol glyceride, 0.5g lauric acid sucrose ester (LWA-1570), 3.0g propylene glycol, 0.55g isopropyl myristate, ginsenoside 0.25g, 5.5g of distilled water for later use.

[0061] 3) Put lecithin, caprylic capric acid macrogol glyceride, lauric acid sucrose ester (LWA-1570), propylene glycol and isopropyl myristate into a beaker, and rapidly in a water bath at 25°C Stir evenly, then slowly add distilled water dropwise to it, and keep stirring until a clear and transparent light yellow solution appears, then add ginsenoside into the system to obtain an oil-in-water ginseng whitening and anti-aging nanoemulsion essence with a particle size of less than 100nm .

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Abstract

The invention relates to the technical field of pharmaceutical nanoemulsion drug delivery systems and transdermal absorption, in particular relates to ginseng-containing whitening and anti-aging nanoemulsion essence and a preparation method thereof, and belongs to a new pharmaceutical technology and the field of study on new formulations applied to cosmetics. The nanoemulsion essence is characterized in that a natural or food-grade emulsifier and an oil phase are selected, wherein double distilled water containing fruit juice, vegetable juice or honey is used as an oil phase. The nanoemulsion essence comprises the following components in percent: 10.30 to 80.60% of emulsifier / co-emulsifier, 1.0 to 40.80% of oil phase, 0.10 to 14.0% of ginseng, and the balance of the water phase. The confocal microscopy result shows that the transdermal absorption mechanism of the essence is the mechanism of majorly dispersing among cells of cutaneous appendages at the beginning and then dispersing and penetrating through cytomembrane. The nanoemulsion essence has high absorption, is innocuous, unpoisonous and pollution-free, does not damage the skin, and can completely realize the green, health, whitening, anti-aging and beautifying makeup concept.

Description

technical field [0001] The invention relates to the technical field of nanoemulsion drug-carrying system and transdermal absorption, belongs to the field of new preparation technology and new dosage form application in cosmetics in pharmacy, and specifically relates to a whitening and anti-aging nanoemulsion essence containing ginseng and a preparation method thereof. Background technique [0002] Ginseng has the titles of "King of Herbs" and "No. , brown spots, butterfly spots and senile skin pigmentation have significant curative effect; ginsenosides also have good anti-ultraviolet function. In addition, ginsenosides can promote the blood circulation of subcutaneous capillaries, increase the nutrient supply of the skin, and regulate the oil-water balance of the skin. Therefore, ginseng can delay skin aging, prevent skin dryness and dehydration, and increase skin elasticity, thereby protecting skin luster and tenderness, and preventing and reducing skin wrinkles. In short...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/98A61Q19/02A61Q19/08
Inventor 丁志英张越孙智辉武敏王晨阳郭秋实闫荟羽李清波
Owner JILIN UNIV
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