Cefpiramide composition
A technology of cefpiramide and cefpiramide, which is applied in powder transportation, antibacterial drugs, organic active ingredients, etc., can solve the problems of content reduction, low temperature storage, poor stability of cefpiramide sodium, etc., and achieve high stability, Rapid dissolution and stable storage quality
Active Publication Date: 2007-09-12
GUANGZHOU BAIYUSN TIANXIN PHARMA
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[0002] At present, cefpiramide sodium powder injection, which is a human antibiotic used clinically, has been widely used. Cefpiramide has obvious therapeutic effects in the treatment of pathogenic bacteria such as Gram-positive bacteria and Gram-negative bacteria. Cefpiramide sodium has good water solubility, but the disadvantage is that the stability of cefpiramide sodium is poor, it needs to be stored at low temperature, and during the storage period, the related substances increase significantly and the content decreases significantly
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[0033] Co-solvents and best co-solvents
[0034]
[0035] It can be seen from the above table that sodium carbonate, sodium phosphate and sodium hydroxide have the shortest dissolution time. Clinically, the faster the drug dissolves, the shorter the dispensing time, which is convenient for clinical application. Therefore, analyze from the dissolution rate of product, the stability of drug and the safety of medication: sodium carbonate is the best cosolvent for preparing cefpiramide for injection.
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The invention provides a Cefpiramide composition which comprises asepsis cefpiramide acid and asepsis solubility promoter, wherein the weight ratio of cefpiramide acid and solubility promoter is 1 : 0.10 to 1 : 0.6. The advantages of the invention include stabilized conserving quality and rapid dissolving in clinic application.
Description
technical field [0001] The invention relates to human antibiotic powder injection, in particular to cefpiramide powder injection for clinical use. Background technique [0002] At present, cefpiramide sodium powder injection, which is a human antibiotic used clinically, has been widely used. Cefpiramide has obvious therapeutic effects in the treatment of pathogenic bacteria such as Gram-positive bacteria and Gram-negative bacteria. The water solubility of cefpiramide sodium is good, but the disadvantage is that the stability of cefpiramide sodium is poor, it needs to be stored at low temperature, and during the storage period, the related substances increase significantly and the content decreases significantly. Contents of the invention [0003] The purpose of the present invention is to provide a cefpiramide composition, which has stable quality when stored at room temperature, and dissolves rapidly in clinical use. [0004] The technical solution of the invention is pr...
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IPC IPC(8): A61K31/546A61K9/14A61P31/04
Inventor 谭胜连郑敏黄粤东傅红燕张涛
Owner GUANGZHOU BAIYUSN TIANXIN PHARMA
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