424results about How to "Control release speed" patented technology

The invention discloses a human-body absorbable trauma dressing containing Yunnan white drug powder or Yunnan white drug powder extractive, which is a novel medicine-carried dressing or a novel formulation of Yunnan white drug powder. The invention has the following remarkable characteristics: (1) the dressing can be absorbed by human bodies to lessen the pain added by dressing change and reduce the treatment cost; (2) the dressing can be made into a film solid dressing or an aquagel dressing so as to expand the use modes, the scope of applications and the drug effect of the Yunnan white drug powder; and (3) the curative effect of the dressing is enhanced by selecting a carrier material, auxiliary medicaments and functional accessories and adjusting the microstructure structure. The novel absorbable Yunnan white drug powder dressing overcomes the defects of the traditional Yunnan white drug powder in use and has economic and social values.

The invention discloses a soluble coaxial-cone multi-layer microneedle. The microneedle is in a cone shape; an internal structure of the microneedle comprises a cone-shaped or conical-cylinder-shaped center layer, and one or more outer layers wrapping the center layer; the center layer and the outer layers are prepared by active drugs and / or structural materials; and a mass ratio of the active drugs to the structural materials is (10:1)-(1:100). The multi-layer structure of the microneedle can be dissolved layer by layer and step by step during intracutaneous contact and body fluid contact, so that the drug release time of one or more drugs and a procedure of drug release dosage can be controlled, and the microneedle can be used for partial skin treatment or whole body administration.

The invention relates to a temperature sensitive gel formulation for in situ vagina uses which is prepared from effective dosage of medicament for treating female vagina infection and macromolecular findings through dissolving into cushioning solution or pure water, and charging poloxamer.

The invention relates to a super-molecule complex containing amino acid and water-solubility pillar [5] arene and a preparation method for the complex. The complex is a [2] pseudorotaxane type complex in an interpenetrating structure by taking the water-solubility pillar [5] arene as a main body and the basic amino acid as a guest through bonding, wherein the molar ratio of the basic amino acid and the water-solubility pillar [5] arene is 1:1, and the structure of the complex containing water-solubility pillar arene and L-arginine is shown in the description. The complex is formed by inclusion, so that the stability of drug molecules can be improved, the drug can be released directionally, the water solubility is improved, the toxicity is lowered, etc. In addition, the complex can be used for improving the stability of unstable and easily-volatile matters such as cosmetics and fragrances, and the water solubility of the complex is also improved.

The invention relates to a sustained-release granular formulation for preventing and treating crop diseases and insect pests and a preparation method thereof. The pesticide sustained-release granular formulation comprises bentonite, an organic modifier, pesticide active ingredients, an inert filler and a binding agent, and is prepared by the preparation method comprising the steps of: (1) with the bentonite as a basic material, modifying the bentonite by the organic modifier to obtain organic bentonite; (2) loading the pesticide active ingredients on the organic bentonite to prepare medicine-carrying organic bentonite; and (3) mixing the medicine-carrying organic bentonite, the inert filler and the binding agent proportionally, and pelleting to obtain the sustained-release granular formulation. The preparation method of the sustained-release granular formulation, provided by the invention, not only overcomes the defect of low pesticide loading rate of the natural bentonite, but also realizes the controlled release of the pesticide by adjusting a chemical structure and the amount of the modifier, so that the sustained-release granular formulation is coincident with an occurrence rule of the plant diseases and insect pests, and the pesticide sustained-release granular formulation is used safely, reasonably, economically and effectively.

A medical empty capsule is prepared from K-carragheenin (0.5-26 Wt portions), the cellulose derivative and / or resin (75-98) and alcohol (1-12) through dissolving them except alcohol in water, adding alcohol to become colloidal liquid, dipping in the colloidal liquid, baking, demoulding, cutting and sleeving.

The invention relates to a slow-release micro drop whose active component is Humeitashen or other salt, wherein it is formed by element and film layer that controlling the drug release, whose weight ratio is 20:1-5:1; the Humeitashen content of element is 10-60%. The invention mainly uses protrusion method to prepare drop, and uses fluidize bed to pack.

The invention relates to a biological glass base porous composite material of a degradable mechanical enhanced type and a preparation method thereof. The material takes a biological glass porous stent which comprises macroporous channels and mediated pore channels as matrix. Adjacent macroporous channels are mutually communicated. The internal and external surfaces of the macroporous channels and mediated pore channels are provided with gel layers which are assembled layer-to-layer by the biomolecules with positive and negative charges alternatively. The biological glass matrix is made from the components with the following weight percentage of 16-38 percent of CaO, 0-10 percent of P2O5, 45-80 percent of SiO2, 0-0.1 percent of SrO and 0-22.5 percent of Na2O. The releasing speed of the biological active ions of the biological glass base porous composite material which is similar to the extracellular matrix and is decorated by the layer-to-layer assembly of the charges of different polarity of the biomolecules can be effectively cut and controlled. The walls of the pore channels are beneficial to the adhesion growth of cells. The mechanical strength, the fracture toughness and the machinability are good. And the application of the regeneration treatment on the bone gear injury home position of a stress concentrated part can be satisfied.

The invention discloses a preparation method of an anticoagulant material with function of inducing and catalyzing release of endogenous NO. The method comprises the steps of: configuring an alkaline Tris-buffer buffer solution, and adding a compound with certain concentration and pyrogallol structure and a compound with disulfide bond or diselenium bond and containing amino or thiol at two ends; and placing the substrate materials in a reaction solution, controlling the reaction temperature, reacting for 1-24 h, removing the substrate, and cleaning and drying to obtain the objective material. The invention has the advantages of simple operation, mild reaction conditions and easy operation. The component unit of the compound with disulfide bond or diselenium bond and containing amino or thiol at two ends has controllable content; the modified coating prepared by the method has excellent adhesion, and catalyzes the blood NO donors to continuously release NO molecules through in situ catalysis, inhibits activation and aggregation of platelets, inhibits proliferation of smooth muscle cells, and protects vascular endothelium.

The invention discloses a long-acting protective liquid self-secreting super-lubricity coating and a preparation method thereof, and belongs to the anti-corrosion, anti-fouling and anti-icing fields and the like. A coating body is an elastic porous film layer and is divided into a bottom layer, an upper layer and a surface layer. The bottom layer is of a large pore structure, the porosity is as high as 60%-95%, the pore diameter ranges from 100 microns to 2000 microns, and the oil storage amount is increased; the upper layer pore diameter ranges from 10 nm to 100 microns, the thickness rangesfrom 50 microns to 1000 microns, oil is prevented from being lost too fast, and the secretion process is controlled; and the surface layer is of a micro-nano-level convex structure, the roughness ranges from 10 nm to 50 microns, and the lyophobic and oil storage effects are achieved. Lubricating oil is stored in the porous structure, when surface oil dries, the oil can be gradually diffused to thesurface layer through upper-layer small holes to form a liquid protective oil film. Corrosion inhibitors, bactericides and the like added into the lubricating oil are released along with the oil, andthe protective function of the coating is enhanced. When environmental water flow impact, external force extrusion, friction and the like lead to losing of the surface oil film, the external force effect will also promote deformation of the elastic porous structure to secrete oil, it keeps that a stable oil layer is formed on the surface, and the service life of the coating is significantly prolonged.

The invention provides a micron nickel phosphide electro-catalytic material used for hydrogen evolution / oxygen evolution double functions and belongs to the technical field of novel materials. A nickel compound is used as a precursor and a high-boiling-point organic matter is used as a solvent; the material has the characteristics of controlling the synthesis of micron nickel phosphide materials on a microcosmic level and the like; preparation conditions are rapid and moderate; a generated compound of Ni2P and Ni5P4 is of micron-grade nickel phosphide particles and the grain diameter is 5-10 microns; the prepared material can be used for electro-catalytic hydrogen evolution and oxygen evolution double functions and has a good electro-catalytic property; and the material has important meanings on industrial production of the micron-scale nickel phosphide material and application and development of the material, and has a relatively wide application range.

The invention discloses a long-acting antibacterial agent, a long-acting antibacterial agent with an instant effect and a preparation method of the long-acting antibacterial agent, and relates to thetechnical field of coating antibacterial agents. The long-acting antibacterial agent mainly comprises nano silver, carrier particles and hydrophilic polymers / a mixture of hydrophilic polymers and hydrophilic inorganic matters, and the long-acting antibacterial agent with the instant effect comprises nano silver, silver salts, other metal salts, carrier particles, hydrophilic polymers / a mixture ofhydrophilic polymers and hydrophilic inorganic matters and a cross-linking agent. By the invention, the problems that a coating film prepared by an existing antibacterial agent is not washable and poor in long-acting property, yellowing of antibacterial active component Ag ions is easily caused, an organic antibacterial agent is harmful to human bodies, pollutes the environment and the like are solved. In addition, hydrophilic polymers or a mixture of the hydrophilic polymers and hydrophilic oligomers or inorganic matters wrap the surface of the antibacterial agent, the releasing speed of silver ions is controlled, and silver simple substances can be promoted to ionize silver ions to resist bacteria.

A microcapsule suspension of high-effect cypermethrin is proportionally prepared from high-effect cypermethrin, core solvent, protective colloid, wall material (urea and formaldehyde), wettable disperser, viscosity regulator and water through pre-polymerizing of urea and formaldehyde, depositing on the surface of core while polymerizing, solidifying and preparing microcapsule suspension. It has low poison and high and durable effect.

The present invention relates to a carry system of oral health-care active component by using viscous material as carrier. It includes adhesive substance for resisting creep deformation and one or several kinds of oral health-care active substances dispersed in adhesive layer or on adhesive layer and contacted with oral tissue, in which the described adhesive substance is pressure-sensitive, it is one of silicon base pressure-sensitive adhesive, copolymer pressure-sensitive adhesive based on acrylic ester, polyethylene or polyisobutylene base pressure-sensitive adhesive, vinyl ether base pressure-sensitive adhesive, ethylene ester base pressure-sensitive adhesive and rubber base pressure-sensitive adhesive or several kinds selected from them. It can ensure the stability of oral health-care active component.

The invention discloses a production method of a readily available and controlled release composite fertilizer containing three nitrogen elements. The production method is as follows: raw materials containing nitric nitrogen, ammonium nitrogen and amido nitrogen are added in materials; in order to prevent that urea reacts with nitro phosphate fertilizer to generate too much urea nitrate and the production can not performed, ammonia gas is introduced in the granulation process according to different proportions to ammonify nitro phosphate fertilizer, reduce the generation of urea nitrate and increase the neutralization degree of monoammonium phosphate; and powdery fundamental fertilizers containing nitrogen, phosphorous and potassium are added to granulate, and then the composite fertilizer can be obtained through drying, cooling, screening and coating. In the production method of the invention, a lot of heat generated in the thermolysis of the nitro phosphate fertilizer and the neutralization heat of the reaction of ammonia gas and monoammonium phosphate are fully utilized to heat materials and increase the granulation temperature; and the viscosity of urea nitrate is utilized, the solubility of ammonium phosphate salt is increased, the quantity of the liquid phase for granulation can be satisfied, higher granulation rate can be realized without using other adhesive, the cost is reduced, the water content of the granulation material is significantly reduced, the drying energy consumption can be reduced and a large amount of energy consumption can be saved.

The invention relates to a preparation technique for a molecular sieve coating material, in particular to a preparation method for a molecular sieve coating material on a porous silicon carbide ceramic surface. Porous silicon carbide ceramic is used as a carrier, solid raw materials such as silicon blocks, quartz, silicon-aluminum composite oxide sintered powder with adjustable silicon-aluminum atomic ratio and the like are used as a silicon source or a silicon-aluminum source, and the raw materials are synthesized through in-situ hydrothermal reaction. The porous silicon carbide ceramic surface is provided with microporous structures. The use of the solid silicon source or silicon-aluminum source can enable the release speed of the silicon source or silicon-aluminum source for the growth of crystal nucleus to be controllable. Thereby, the prepared molecular sieve coating is evenly loaded on the surface of the silicon carbide ceramic carrier, the silicon-to-aluminum ratio can be accurately controlled, and the composite material formed by the molecular sieve and the porous silicon carbide ceramic has unique microporous / macroporous structures; and the chemical bonding between the molecular sieve and the porous silicon carbide ceramic is realized and the interfacial bonding strength is high. The invention has the advantages that the technology of the method is simple, the operation is convenient, the complex equipment is not required, the preparation cost is low and the method is more suitable for industrialized mass production.

The invention relates to a preparation method for antimony-doped tin oxide powder. The preparation method comprises the following steps of mixing antimony trichloride, tin tetrachloride pentahydrate and a compounding ingredient, adding into a hydrochloric acid solution, and uniformly stirring a mixed solution to obtain transparent liquid; uniformly mixing a dispersing agent, tin tetrachloride pentahydrate, water and ethanol to obtain a base solution; dropwise adding the transparent liquid and an ammonium hydroxide precipitating agent into the base solution within 30 to 80 minutes in a double titration way, controlling reaction temperature to be 50 to 60 DEG C while stirring, and controlling final reaction pH to be 5 to 6; stopping stirring after titration, and performing curing to obtain precursor suspension; performing filtration, water washing, alcohol washing, azeotropic distillation, drying, grinding and calcination on obtained precursor precipitates. According to the method, tin and antimony are synchronously hydrolyzed and precipitated, and antimony is uniformly doped; the powder prepared by the method has the advantages of small particle size, loose structure, low agglomeration rate, high dispersibility and the like.

The invention relates to a method for preparing biological pesticide spinosad microcapsule preparation, which comprises preparation of urea-formaldehyde prepolymer solution, preparation of spinosad mixture solution and preparation of spinosad microcapsule. The microcapsule preparation technique is simple and convenient, easy to control, stable in reaction, less in auxiliary additive, low in production cost and suitable for industrialized production. The spinosad prepared by the method has high coating efficiency, is not damaged by rainwater or does not have degradation phenomenon after being irradiated by light, has long slow release period, and prolongs the pest control period, thus not only improving the control effect, but also reducing the environmental pollution.

Disclosed is a cigarette use biological addition agent and use thereof, wherein the biological enzyme comprises degraded proteinase, amylase, pectic enzyme, polysaccharide degraded enzyme, cellulose, surface active agent, enzyme activating agent, wall material, emulsifying agent, and cushioning liquid. The preparing process comprises the steps of agitating, immobilizing, and utilizing addition agent.

The invention relates to an amphipathy block copolymer-Paclitaxel compound and relative preparation, wherein said invention is formed by bonded aliphatic polyester-carbowax-aliphatic polyester block copolymer and Paclitaxel; with hydroxyl carbowax (PEG), solvent and catalyst, it processes the ring-opening polymerization of aliphatic ester to obtain the liphatic polyester-carbowax-aliphatic polyester block copolymer, then converting the hydroxyl grouyp into end carboxyl; with condensating agent, processing genate reaction with Paclitaxel, to obtain the inventive drug. The invention has amphipathy property, to be made into liquid agent or freeze dried. And its block structure can improve the Paclitaxel content, adjusted between 10-40%.

The invention discloses emulsified type air purification gel. The emulsified type air purification gel is prepared from a compound gel agent, an emulsifier and a slow releasing agent. The air purification gel disclosed by the invention can be used for effectively controlling the volatilizing speed of volatile functional components, and long-effect linear releasing of the volatile functional components is realized. Furthermore, the invention further discloses a preparation method of the emulsified type air purification gel; the preparation method is simple in equipment and easy to operate; the prepared air purification gel can be used for effectively controlling the volatilizing speed of a deodorant, is used for eliminating bad odor in the air and purifying harmful gas including formaldehyde, benzene and the like in the air, and has good sterilization effect.

The invention relates to a method for preparing a leather fixing agent, in particular to a dendriform cationic leather fixing agent and a preparation method thereof. To overcome the defects of low activity, high consumption and easily caused grain leather existing in the prior art, the invention adopts a technical scheme that: the method for preparing the dendriform cationic leather fixing agent comprises the following steps: (1) mixing organic amine and acrylic ester, adding a reaction solvent, stirring to react, vacuumizing, distilling by rotating, and removing the solvent and excessive acrylic ester to prepare dendriform PAMAM; and (2) mixing the dendriform PAMAM prepared in the step (1) with a cationic etherifying agent, adding a solvent, adding an extracting agent after reaction, andextracting for multiple times to prepare graft modified dendriform cationic leather fixing agent. Compared with the prior art, the method has the advantages of reducing the hydrolysis effect of dye, improving fastness of leather to wet rubbing, reducing the consumption of the dye, not influencing the hand feeling of the leather, and making the fixing agent biologically degraded easily.

The invention discloses an anthracycline liposome injection, including the injection and a frozen powder injection and a preparation process of the injection. The frozen liposome consists of the anthracycline or an anthracycline hydrochloride, compound neutral phospholipids, surfactant, negative-charge phospholipids, buffers, PH regulators and freezing protection agent. The preparation process includes the following steps: preparation of a hollow liposome, a homogenized liposome, an anthracycline lopsome and an anthracycline lopsome suspension; adding the freezing protection agent; constant volume; sterilization; sub-package; freezing and drying; storage, etc. The liposome injection can be preserved for 12 months under the room temperature with better stability. And the encapsulation rate can be above 95 percent and a granule diameter is between 30 and 300mm. The side effect is low and the technique is simple, thus being convenient for industrial production.

The invention belongs to the technical field of biological materials, and in particular relates to a preparation method for a borate antibacterial glass coating with bioactivity and application thereof. The preparation method comprises the following steps of: preparing sterilization ion-containing borate glass; smashing and screening the glass; uniformly coating the glass powder onto the surface of an implanted device; performing thermal treatment to make the glass powder have viscosity; and forming an antibacterial coating covered on the surface of the implanted device. The preparation method has the characteristics of simple equipment, easy operation and low cost. The coating of the invention has the bioactivity, can be coated on the surface of the implanted device firmly, and can effectively improve the bioactivity and the antibacterial property of conventional implanted materials.

The invention discloses a method for preparing a Ag / Ag3PO4 composite photo-catalyst. The method comprises the following steps of: mixing and stirring pyridine and aqueous solution of AgNO3 uniformly to form a pyridine silver solution; adding phosphate into the pyridine silver solution, mixing uniformly, reacting with stirring to generate Ag3PO4 sediment, and regulating the pH value of the mixed solution by adding phosphoric acid or sodium hydroxide; and heating with sealing, reacting at a controlled temperature, naturally cooling to room temperature after reaction, filtering and washing the product, drying the obtained sediment in a vacuum oven in a shading mode, and thus obtaining the Ag / Ag3PO4 composite photo-catalyst. The phosphate is one of trisodium phosphate, disodium hydrogen phosphate, sodium dihydrogen phosphate, tripotassium phosphate, dipotassium hydrogen phosphate and potassium dihydrogen phosphate; and the purities of the chemical reagents are greater than chemical purities. The method is easy to operate, and facilitates industrialized production; and the prepared Ag / Ag3PO4 composite photo-catalyst is high in quantum efficiency and high in photo-stability.

The present invention discloses a drug sustained release composition sparingly soluble or slightly soluble in water, comprising non-solvent based raw material: a releasing conditioning agent. In the composition, the releasing conditioning agent is added into preparation raw materials and can be used for effectively adjusting the releasing speed of the drug sustained release composition sparingly soluble or slightly soluble in the water, so that a phenomenon of obvious releasing delaying period and burst releasing of the drug sustained release composition sparingly soluble or slightly soluble in the water is avoided, the good sustained release performance is obtained, the therapeutic plasma concentration can be kept for several weeks or even more, the stabilization is relatively good, and the releasing behavior of the drug can be maintained after long-time storage. At the same time, the present invention also discloses a preparation method of the drug sustained release composition sparingly soluble or slightly soluble in the water.

The invention provides a preparation method of a buckwheat flavone microcapsule, which comprises the following steps: 1) pretreating: drying buckwheat grain, buckwheat shell, buckwheat husk or buckwheat stem leaf, sieving after crushing for standby to obtain buckwheat powder; 2) extracting; 3) separating and purifying; 4) preparing a capsule emulsion: uniformly mixing a core material, a wall material and an emulsifier to prepare a buckwheat flavone microcapsule emulsion; 5) spray drying to obtain the buckwheat flavone microcapsule. The invention has the advantages that: 1, the activity of an active component flavone substance in buckwheat is protected; 2, the buckwheat flavone is prevented from damage of gastric acid, has certain targeting after microencapsulation, and has good enteric solubility but insolublility in stomach; 3, the bitter taste of buckwheat is covered; 4, the release speed is controlled, the flavone substance can not be stored in vivo, and the concentration of the flavone substance is rapidly increased in vivo after taking and rapidly decreasing due to metabolism degradation effect, the microencapsulation enables a slow release function and releases functional factors in certain time and scope.

The invention discloses a prodrug system prepared by connecting a series of oligopolymers synthesized by a group protection and deprotection method and polyethyleneglycol to be used as a drug carrier, belonging to the technical field of chemical drugs. Laden drugs are water-insoluble anti-tumor drugs such as taxol, or other cancer therapy drugs such as doxorubicine and camptothecin. A research discovers that drug compositions prepared by the method greatly improve the hydrophobic nature of the anti-tumor drugs and can accurately control the gather time of the oligopolymers on focus parts and the hydrolyzation rupture time of ester bonds by accurately controlling the lengths of segmers of the oligopolymers so as to control the drug release time so that drugs are stably released, thereby the method prevents burst release causing toxic side effect on normal cells, reduces the drug dosage to enhance the curative effect and sufficiently plays a sustained and controlled release role; and in addition, the structure of the oligopolymers is accurate, and the molecular weight of synthesized amphipathic block polymers which are uniformly distributed is accurate, thereby the method can ensure synthesized drug ingredients to be definite and stable and the pharmacokinetics and the treatment effect (activity and toxicity) of the synthesized drugs to have good reproduction quality and be accurately defined.

The invention relates to a preparation method of a molecular sieve coating material on the surface of porous silicon carbide ceramic with the surface rich in silicon, and the molecular sieve coating material is prepared by using the porous silicon carbide ceramic with the surface rich in silicon as a carrier; using solid materials, such as silicon blocks, quartz, sliicon-alumininm composite oxide sintering powder with adjustable sliicon-alumininm atomic ratio, and the like as a silicon source or a sliicon-alumininm source, and adopting a in situ hydrothermally synthesizing method. Molecular sieve crystals preferentially nucleate on the surface of the porous silicon carbide ceramic due to a surface silicon layer of the porous silicon carbide ceramic, the solid silicon source or the sliicon-alumininm source are used so that the release speed of the silicon source or sliicon-alumininm source for the growth of crystal nucleus is controllable. Therefore, prepared molecular sieve coating is uniformly loaded on the surface of the silicon carbide ceramic carrier; the composite material formed by a molecular sieve and the porous silicon carbide ceramic has a unique micropore / macropore structure; chemical combination is realized between the molecular sieve and the porous silicon carbide ceramic, and the molecular sieve and the porous silicon carbide ceramic have high interface combination strength. The preparation method has simple technology, convenient operation without complex equipment and low manufacturing cost and is more suitable for industrialized and mass production.

The present invention relates to a blood vessel medicine scaffold, including blood vessel scaffold, medicine and carrier, in which the medicine is coated on the surface of said blood vessel scaffold by means of carrier. The described medicine is rolimus medicine or mixture of rolimus medicine and taxol and / or hirudin, and said rolimus medicine is one of sirolimus, tacrolimus and eotarolimus or mixture of more than two kinds of them.