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Super-molecule complex containing amino acid and water-solubility pillar [5] arene and preparation method for complex

A water-soluble, amino acid technology, applied in the preparation of organic compounds, cyanide reaction preparation, medical preparations of non-active ingredients, etc., can solve the problems of inclusion coordination that have not been reported, to increase water solubility, improve Stability, toxicity reduction effect

Inactive Publication Date: 2013-02-06
SHANGHAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the research on the derivatization and molecular recognition of new supramolecular hosts such as pillararene has become a research hotspot in the field of supramolecular chemistry. However, the inclusion and coordination of pillararene to biological and drug molecules has not been reported.

Method used

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  • Super-molecule complex containing amino acid and water-solubility pillar [5] arene and preparation method for complex
  • Super-molecule complex containing amino acid and water-solubility pillar [5] arene and preparation method for complex
  • Super-molecule complex containing amino acid and water-solubility pillar [5] arene and preparation method for complex

Examples

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Embodiment 1

[0030] Example 1: Take 1mM (0.146g) of lysine (Lys), arginine (Arg) or histidine (His), and 1mM (2.646g) of CP5A, and mix them evenly under solid conditions. Under the conditions of oil bath and electromagnetic stirring, slowly add deionized water until the solid is just dissolved (the amount of deionized water should be as little as possible). After completely dissolving, it was naturally cooled to room temperature, and crystals were precipitated. Then put it in the refrigerator for 1 hour at 2°C. The precipitated complex was filtered under reduced pressure and dried to obtain the complex.

[0031] in D 2 In O, a single host, a single guest, and a mixture of host and guest are measured for one-dimensional nuclear magnetic spectrum ( 1 H NMR), analysis of CP5A (mode of action with standard amino groups) CP5A NMR 1 H NMR and 13 C NMR spectrum as figure 1 with figure 2 shown.

[0032] image 3 For CP5A and the guest Lys and Arg in D 2 O without adding and adding 1.0e...

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Abstract

The invention relates to a super-molecule complex containing amino acid and water-solubility pillar [5] arene and a preparation method for the complex. The complex is a [2] pseudorotaxane type complex in an interpenetrating structure by taking the water-solubility pillar [5] arene as a main body and the basic amino acid as a guest through bonding, wherein the molar ratio of the basic amino acid and the water-solubility pillar [5] arene is 1:1, and the structure of the complex containing water-solubility pillar arene and L-arginine is shown in the description. The complex is formed by inclusion, so that the stability of drug molecules can be improved, the drug can be released directionally, the water solubility is improved, the toxicity is lowered, etc. In addition, the complex can be used for improving the stability of unstable and easily-volatile matters such as cosmetics and fragrances, and the water solubility of the complex is also improved.

Description

technical field [0001] The invention relates to a functional supramolecular complex and a preparation method thereof. In particular, a supramolecular complex of amino acid and water-soluble column [5] arene and its preparation method. Background technique [0002] The concept of molecular recognition was originally proposed by organic chemists and biochemists to study chemical problems in molecular research biological systems. Molecular recognition produces catalysis through transformation and translocation processes. In biological systems, it is the source of information for understanding enzymatic reactions, information transfer, and energy transfer phenomena between species in different media. In the field of analytical chemistry, it constitutes the basis for separation, detection and quantitative determination. Base. The formation of supramolecular inclusions is based on molecular recognition. [0003] The synthesis and decomposition of molecules in organisms, the tra...

Claims

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Application Information

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IPC IPC(8): C07C229/26C07C227/18C07C279/14C07C277/08C07D233/64A61K47/48
Inventor 李春举马俊伟胡小诗
Owner SHANGHAI UNIV
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