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Mupirocin ointment and preparation method thereof

A technology of mupirocin and ointment, which is applied in the field of drug synthesis, can solve the problems of unsatisfactory drug effect and poor stability, and achieve the effect of high stability and good drug effect

Active Publication Date: 2012-02-01
BEIJING UNION PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The inventor's new type of cream made from this ingredient can be very stable even without added chemical agents like mophorimox or other similar drugs that may have side-effects on healthy people who are taking them for medical purposes.

Problems solved by technology

This patented technical problem addressed in this patents relates to improving the stability and efficiency of certain types of drugs that are commonly prescribed or administered through injection into humans due to their instability when exposed to acids/alkalis during storage at room temperature.

Method used

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  • Mupirocin ointment and preparation method thereof
  • Mupirocin ointment and preparation method thereof
  • Mupirocin ointment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] formula:

[0029]

[0030] Preparation method: Dissolve 1 g of citric acid in 391 g of polyethylene glycol 400, then add 98 g of polyethylene glycol 4000, heat to melt in a water bath at 60 ° C, then add 10 g of mupirocin, Stir in a water bath at ℃ to dissolve mupirocin, mix evenly, and cool to room temperature to obtain mupirocin ointment.

Embodiment 2

[0032] formula:

[0033]

[0034] Preparation method: Dissolve 0.2 g of tartaric acid in 317 g of polyethylene glycol 400, then add 179.8 g of polyethylene glycol 4000, heat to melt in a water bath at 55° C., then add 3 g of mupirocin, and Stir in a water bath at 55°C to dissolve mupirocin, mix evenly, and cool to room temperature to obtain mupirocin ointment.

Embodiment 3

[0036] formula:

[0037]

[0038] Preparation method: Dissolve 2g of lactic acid in 420g of polyethylene glycol 400, then add 53g of polyethylene glycol 4000, heat in a water bath at 60°C until melted, then add 25g of mupirocin, and heat at 60°C Stir in a water bath to dissolve mupirocin, mix evenly, and cool to room temperature to obtain mupirocin ointment.

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Abstract

The invention relates to a mupirocin ointment which comprises the following components in percent by weight: 0.5-5 percent of mupirocin, 60-89 percent of polyethylene glycol 400, 10-36 percent of polyethylene glycol 4000 and 0.04-0.4 percent of organic acid. The invention also discloses a preparation method of the mupirocin ointment. Because the mupirocin ointment provided by the invention contains the organic acid as a stabilizing agent, compared with the traditional mupirocin ointment, the mupirocin ointment has higher stability and low content of related substances and better treatment effect during clinical application.

Description

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Claims

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Application Information

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Owner BEIJING UNION PHARMA FACTORY
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