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Cannabidiol-tannic acid-polyvinyl alcohol hydrogel wound dressing and preparation method thereof

A cannabidiol and polyvinyl alcohol technology, which is used in pharmaceutical formulations, medical science, drug delivery, etc., can solve the problem that secretions and sweat cannot be discharged in time, the Band-Aid cannot be applied perfectly, and there is no air permeability and waterproofness. To prevent wound infection and inflammation, promote wound healing, and avoid wound inflammation

Pending Publication Date: 2022-04-15
哈尔滨工业大学重庆研究院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, commonly used wound dressings, such as Band-Aid, are limited by their materials and have defects that cannot be ignored. They do not have good air permeability and water resistance, and the secretions and sweat at the wound cannot be discharged in time. Soaking in liquid may lead to infection and other conditions, thus affecting wound healing
When encountering large-area or complex-shaped, special wounds, traditional band-aids cannot be perfectly applied to the wound surface, and it is not convenient to use
And the sticky coating is very sticky, which may cause pain or even damage to the surrounding skin when the Band-Aid is torn off
In addition, the sustained release performance of wound dressings at this stage is insufficient, and the anti-inflammatory and antibacterial functions also need to be further improved

Method used

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  • Cannabidiol-tannic acid-polyvinyl alcohol hydrogel wound dressing and preparation method thereof
  • Cannabidiol-tannic acid-polyvinyl alcohol hydrogel wound dressing and preparation method thereof
  • Cannabidiol-tannic acid-polyvinyl alcohol hydrogel wound dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Preparation of hydrogel precursor: 3G concentration of 50% is mixed with 3 g of polyvinyl alcohol powder, so that the mass fraction of polyvinyl alcohol accounts for 30% of the total mass of the hydrogel dressing, two The mixture was stirred at an 80 ° C water bath until a uniform viscous liquid was obtained.

[0034] (2) Preparation of the pharmaceutical hydrogel precursor: The resulting hydrogel precision preparation in step (1) is allowed to stand, cool to 40 ° C, add 0.3 g of hemp 1 gonol and 0.2g Mororos' powder, then Stir well.

[0035] (3) Preparation of a pharmaceutical hydrogel: Pour the drug hydrogel precursor obtained in step (2) into the mold, put it in the -20 ° C refrigerator for 6 h, after 6 h, thawing, can obtain cannabis phenol- Tannic acid - polyvinyl alcohol hydrogen.

[0036] Under the conditions of Example 1, the oxidation capacity of hemp phenol-tannin-tannic acid-polyvinyl alcohol hydrogel (using DPPH free radical removal rate), image 3 The DPPH r...

Embodiment 2

[0039] (1) Preparation of hydrogel precursor: 3G concentration of 50% is mixed with 3 g of polyvinyl alcohol powder, so that the mass fraction of polyvinyl alcohol accounts for 30% of the total mass of the hydrogel dressing, two The mixture was stirred at an 80 ° C water bath until a uniform viscous liquid was obtained.

[0040] (2) Preparation of the pharmaceutical hydrogel precursor: The resulting hydrogel precision precursor in step (1) is allowed to be placed, cooled to 40 ° C to add 0.1 g of cannabinol and 0.2 g of Moirot, then Stir well.

[0041] (3) Preparation of a pharmaceutical hydrogel: Pour the drug hydrogel precursor obtained in step (2) into the mold, put it in the -20 ° C refrigerator for 6 h, after 6 h, thawing, can obtain cannabis phenol- Tannic acid - polyvinyl alcohol hydrogen.

[0042] In the case of the second embodiment, the oxidation capacity of the hemp diphenol-tannic acid-polyvinyl alcohol hydrogel (using DPPH free radical clearance to represent anti-oxida...

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Abstract

The invention relates to a cannabidiol-tannic acid-polyvinyl alcohol hydrogel wound dressing and a preparation method thereof. The method comprises the steps of preparation of a hydrogel precursor, preparation of a drug-loaded hydrogel precursor and preparation of drug-loaded hydrogel. According to the cannabidiol-tannic acid-polyvinyl alcohol hydrogel wound dressing disclosed by the invention, cannabidiol and mupirocin are used as main medicinal components in the wound dressing, and hydrogel is prepared from tannic acid and polyvinyl alcohol through a freeze thawing method. The cannabidiol-tannic acid-polyvinyl alcohol hydrogel wound dressing prepared by the method has the characteristics of bacteriostasis and anti-inflammation, and can protect an affected part, prevent wound infection and promote wound healing.

Description

Technical field [0001] The present invention belongs to the technical field of biomedical materials, and more particularly to a medical article and a preparation method thereof, in particular to cannabis diol-tannic acid-polyvinyl alcohol water gel wound dressing and preparation method thereof. Background technique [0002] At this stage, the commonly used wound dressings, such as creating a licensed, subject to its own material itself, has an irreversible flaw, which does not have good breathable and waterproof, secretions and sweat in the wound, can not be discharged in time, the wound is here The liquid soaking may result in the occurrence of infection, thereby affecting the healing of the wound. When encountering a large area or a complicated, special wounds, traditional creation cannot be perfectly applied to the surface of the wound, which is not convenient. Moreover, the viscous coating has a strong viscosity, and it may cause pain or even damage to the surrounding skin wh...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0014A61L26/008A61L26/0066A61L26/0061A61L2400/04A61L2300/216A61L2300/406A61L2300/41A61L2300/602C08L29/04
Inventor 卢卫红李琳洁
Owner 哈尔滨工业大学重庆研究院
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