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Method for preparing nano-fiber dressing by virtue of electrospinning method

An electrospinning method and nanofiber technology, applied in the field of preparation of medical dressings, can solve the problems of poor antibacterial effect and weak strength, achieve high swelling rate and mechanical strength, and suppress pain

Inactive Publication Date: 2017-05-10
SHAANXI YIPINDA PETROCHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, when the existing medical dressings are used as wet dressings, they have weak strength and poor antibacterial effect

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0015] A method for preparing a nanofiber dressing by electrospinning, comprising the following steps:

[0016] (1) Prepare a 0.1 g / mL type I collagen solution with hexafluoroisopropanol as a solvent, add lidocaine to obtain the outer spinning solution;

[0017] (2) Prepare a 0.2 g / mL polycaprolactone solution with dichloromethane as a solvent, and add mupirocin to obtain an inner layer spinning solution;

[0018] (3) Add the outer layer spinning solution and the inner layer spinning solution obtained in step (1) and step (2) respectively into two syringes, connect them with coaxial needles to form a coaxial structure for high-voltage electrospinning, spinning Parameters: Positive voltage 17kV, negative voltage -3 kV, inner PCL flow rate 3mL / h, outer collagen 1 mL / h, receiving distance 15cm, vacuum-dry the obtained dressing at room temperature for 24h;

[0019] (4) Soak the dressing obtained in step (3) in 0.1 g / mL genipin ethanol solution, react for 3 h, wash the dressing wi...

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Abstract

The invention discloses a method for preparing a nano-fiber dressing by virtue of an electrospinning method. The preparing method comprises the following steps: preparing a 0.1g / mL type I collagen solution by taking hexafluoroisopropanol as a solvent, and adding lidocaine, so that outer spinning liquid is obtained; preparing a 0.2g / mL polycaprolactone solution by taking dichloromethane as a solvent, and adding mupirocin, so that inner spinning liquid is obtained; and adding the outer spinning liquid and the inner spinning liquid into two injectors, connecting the two injectors by virtue of a coaxial needle, so that a coaxial structure is formed for conducting high-pressure electrostatic spinning, drying an obtained dressing in a vacuum environment and soaking the dried dressing in an ethanol solution of genipin, washing the dressing with ethanol and drying the dressing, so that the nano-fiber dressing is obtained. The prepared nano-fiber dressing is higher in swelling rate and mechanical strength; the nano-fiber dressing is more suitable to be used as a wet dressing and for absorbing exudation; and the nano-fiber dressing is excellent in long-term use resistance, antibacterial performance and the like.

Description

technical field [0001] The invention belongs to the field of preparation of medical dressings, and in particular relates to a method for preparing nanofiber dressings by an electrospinning method. Background technique [0002] Medical dressings are important auxiliary medical supplies, mainly used for the treatment of surgical wounds, burns and skin ulcers caused by various chronic diseases. Early dressings had the single function of simple protection and infection prevention. With the continuous development of medical technology, functional dressings that can relieve pain of patients, absorb exudate and antibacterial to prevent infection, reduce scars and shrinkage, and promote healing have emerged as the times require, and they are more and more important in clinical practice. important role. [0003] Electrospinning technology has excellent controllability in the preparation of dressings. The dressings prepared by electrospinning technology also have the advantages of a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/32A61L15/44D01D5/00D06M13/224D01F8/02D01F8/14D06M101/32
CPCD01D5/003A61L15/26A61L15/325A61L15/44A61L2300/204A61L2300/216A61L2300/402A61L2300/404D01D5/0092D01F8/02D01F8/14D06M13/2246D06M2101/32
Inventor 李长英
Owner SHAANXI YIPINDA PETROCHEM CO LTD
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