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Flurbiprofen coating agent and preparation method thereof

A technology of flurbiprofen and coating agent, which is applied in the field of coating preparation, can solve the problems of short residence time of solution, no sustained-release effect of liniment, easy oxidation and rancidity of ointment, etc., and achieve good skin coupling effect and curative effect Definite, quality-controlled standards workable results

Inactive Publication Date: 2016-01-13
CHENGDU AIBIKE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, flurbiprofen preparations have many defects. The solution stays on the skin for a short time and is inconvenient to carry; the powder is not suitable for skin diseases with exudate or purulent secretion; the ointment is easy to oxidize and become rancid, and is not easy to clean; The liniment has no sustained release effect, and the effect is difficult to last

Method used

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Embodiment

[0022] The flurbiprofen coating agent of the present embodiment, expressed by weight, by flurbiprofen 5g, chitosan 10g, carbomer 10g, glycerol 100g, lauryl azone 10g, ethanol 600g, purified water 650g composition.

[0023] Among them, the viscosity of chitosan is 50mPa·s, and its degree of deacetylation is not less than 80%.

[0024] The preparation method of described flurbiprofen coating agent, comprises the following steps:

[0025] (1) Take 300g of purified water, sprinkle 10g of chitosan and 10g of carbomer on the surface of the purified water to make it swell naturally, and heat it to dissolve into a glue;

[0026] (2) After mixing 100g of glycerol and 600g of ethanol, add 5g of flurbiprofen, and mix evenly to obtain a mixed solution;

[0027] (3) Add the glue solution in step (1) to the mixed solution in step (2) and stir evenly;

[0028] (4) Add 10 g of laurocaprazine, add 650 g of purified water, and stir thoroughly to obtain flurbiprofen varnish.

[0029] Wherein...

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Abstract

The invention discloses a flurbiprofen coating agent, comprising, by weight, 8-15 g of flurbiprofen, 5-20 g of chitosan, 8-15 g of carbomer, 83-125 g of glycerol, 8-15 g of laurocapram, 200-600 g of ethyl alcohol, and 500-900 g of purified water. A preparation method includes: 1, spreading 10 g of chitosan and 10 g of carbomer to the surface of 300 g of purified water so that the chitosan and the carbomer naturally swell, and performing heating so that the chitosan and the carbomer dissolve into glutinous slurry; 2, mixing 100 g of glycerol and 600 g of ethyl alcohol, adding 5 g of flurbiprofen, and performing uniform mixing to obtain mixed liquid; 3, adding the glutinous slurry of step 1 into the mixed liquid of step 2, and performing uniform mixing; 4, adding 10 g of laurocapram, adding 650 g of purified water, and performing full mixing to obtain the flurbiprofen coating agent. The flurbiprofen coating agent is convenient to administer and has exact curative effect; the preparation process is simple and reasonable and meets the requirement on coating agent quality.

Description

technical field [0001] The invention relates to the field of preparation of film-coating agents, in particular to a film-coating agent of flurbiprofen and a preparation method thereof. Background technique [0002] Flurbiprofen is a propionic acid non-steroidal anti-inflammatory drug, which has analgesic, anti-inflammatory and antipyretic effects, and is clinically used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and other diseases. Oral administration of ordinary tablets can cause side effects such as gastrointestinal reactions. At present, flurbiprofen preparations have many defects. The solution stays on the skin for a short time and is inconvenient to carry; the powder is not suitable for skin diseases with exudate or purulent secretion; the ointment is easy to oxidize and become rancid, and is not easy to clean; Liniments have no sustained-release effect, and the effect is difficult to last. The advantage of the coating agent is that after be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/192A61K47/10A61K47/36A61K47/32A61P29/00A61P19/02A61P19/08
Inventor 何金蓉
Owner CHENGDU AIBIKE BIOTECH
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