1169 results about "Sodium azide" patented technology

A gas generating composition having an improved thermal stability of a fuel is obtained.A gas generating compostion comprising a gas generating agent containing a non-sodium azide compound fuel and an oxidizing agent, and an adsorbent. Since substances accelerating decomposition of a fuel, such as radicals generating by decomposition of the fuel are adsorbed and kept on the adsorbent, further decomposition of the fuel is inhabited, so that the thermal stability is increased.

The invention discloses a cyclodextrin chiral stationary phase, the structure of which is shown in the general formula (I), wherein X is -OCH3 or -OCH2CH3, n is equal to 1-7, and R is -H, -CH3, -COCH3, -COC6H5 and -CONHC6H5. The preparation method of the stationary phase comprises the following steps: a silane coupling agent, sodium azide and a catalyst are added into an organic solvent, then spheroidal silicon is added for preparing azide silica gel derivant; oligomeric ethylene glycol, sodium hydride and propargyl bromide are added into tetrahydrofuran for preparing bialkynyl oligomeric ethylene glycol; monosubstituted nascent and derivative cyclodextrin containing azid groups is prepared; finally, the click chemistry reaction method is used for bonding the cyclodextrin. The cyclodextrin chiral stationary phase has the advantages that the selectivity of the bonding reaction is high, and the surface bonded amount is large; the chiral separation ability is strong, thereby being especially suitable for the chiral separation of a high efficiency liquid chromatography in the reversed-phase mode; the preparation method is simple and has less steps, the bonding reaction is the click chemistry reaction, the reaction condition is mild, and the reaction is carried out in the water solution.

The invention belongs to the technical fields of organic chemistry and pharmaceutical chemistry, and specifically relates to a preparation method of a 2-deoxy-beta-D-glucopyranosyl triazole compound. According to the invention, a 1,2-deoxy-7-C-acetyl-alpha-D-glucopyranose derivative is subject to a reaction with sodium azide, such that 2-deoxy-beta-D-glucopyranosyl nitrine is produced. Terminal alkyne and a catalyst copper iodide are added to the same reactor, and the 2-deoxy-beta-D-glucopyranosyl triazole compound is produced through a reaction. According to the invention, a one-pot method is adopted, and the method has advantages of mild reaction condition, simple reaction operation, green and environment-protective solvent, and high yield.

The invention provides a method for preparing 5, 5'-bistetrazole-1, 1'-dioxo hydroxyl ammonium salt (TKX-50), and belongs to the technical field of organic synthesis. The method comprises the steps as follows: step one, glyoxime is prepared, and the yield is 62%; step two, a product obtained in the step one is dissolved in water and concentrated hydrochloric acid, chlorine is introduced at the temperature of 0 DEG C for a reaction for a period of time, and dichloroglyoxime is obtained; and finally, a product obtained in the step two is dissolved in a solvent, and the product and sodium azide have a reaction at the temperature of 0 DEG C for a period of time; after that, the mixture is transferred into diethy ether, and sealed for a reaction at the room temperature overnight after HCl is introduced for a period of time; and after diethyl ether and most HCl gas are volatilized, pH of an aqueous NaOH solution is regulated to be about 8, reflux cooling is performed, filtered and separated solids are dissolved in hydroxylamine hydrochloride to have a reaction for a period of time, and TKX-50 is obtained. According to the method, glyoxal is adopted as a raw material, water is adopted as a solvent for preparation of dichloroglyoxime in the step two, and only direct filtration is required in postprocessing, so that the tedious purification process is prevented, and the cost is reduced; and besides, a target product TKX-50 is synthetized through three steps of reactions, the total yield is up to 34%, the reaction condition is mild, the operation is simple and convenient, and the industrialization is easy to realize.

A fire suppressing gas generator includes a cylindrical housing comprising an array of discharge ports distributed generally uniformly therearound; a cylindrical filter disposed within the housing and spaced from the interior wall of the housing; a plurality of azide-based propellant grains inside the cylindrical filter; and at least one ignition device associated with the propellant grains. The propellant grains when ignited by the ignition device generate a fire suppressing gas which passes through the filter and out of the discharge ports of the cylindrical housing for delivery into a space.

The invention relates to the technical field of chemical engineering and in particular relates to a layer-by-layer clicked, bonded and self-assembled graphene oxide polyolefin separation membrane and a preparation method thereof. The preparation method comprises the following steps: mixing an unmodified polyolefin separation membrane with bromine and irradiating bromine by ultraviolet light so as to prepare a bromo-membrane; performing nucleophilic substitution on the bromo-membrane and sodium azide to prepare a polymer membrane with an azide group; preparing graphene oxide with the azide group and alkynyl by using open-looping and condensation methods; performing layer-by-layer clicking, bonding and self-assembling on the graphene oxide with the azide group and alkynyl to be formed onto the surface of the polyolefin separation membrane with the azide group, thereby achieving layer-by-layer clicking and self-assembling modification on graphene oxide on the surface of the polyolefin separation membrane. The preparation method is a universal method for polyolefin separation membrane surface modification. The hydrophilia and the anti-pollution property of the polymer membrane are improved, the polyolefin separation membrane is permanently modified, and thus the polyolefin separation membrane can be widely applied to the field of chemical engineering.

A one-pot process for preparing ammonium and hydroxylammonium salts of bis 5,5′-tetrazole-1,1′-dihydroxide, specifically, diammonium bis 5,5′-tetrazole-1,1′-diolate (ABTOX) and dihydroxylammonium 5,5′-bistetrazole-1,1′-diolate (TKX-50). The process requires the reaction of sodium azide, dichloroglyoxime, HCl in dioxane solution to form bis 5,5′-tetrazole-1,1′-dihydroxide and treating this product with either ammonium chloride to produce ABTOX or hydroxylamine hydrochloride to produce TKX-50.

The invention provides a tetrazole-containing polymer of intrinsic microporosity comprising (10) or more subunits, wherein one or more of the subunits comprise one or more tetrazolyl moieties. In one embodiment, a polymer of intrinsic microporosity (PIM-1) was modified using a “click chemistry” [2+3] cycloaddition reaction with sodium azide and zinc chloride to yield new PIMs containing tetrazole units. Polymers of the present invention are useful as high-performance materials for membrane-based gas separation, materials for ion exchange resins, materials for chelating resins, materials for superabsorbents, materials for ion conductive matrixes, materials for catalyst supports or materials for nanoparticle stabilizers.

The invention provides a human blood fat (serum / plasma) quality management reference kit. The kit takes human serum (plasma) as a matrix; a human blood fat component (human apolipoprotein A1 antigen, apolipoprotein B antigen, high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL) and the like), a stable system and an anticorrosion system are added to the matrix; the stable system is any combination of a surfactant of Triton series, Tween series, EDTA (ethylene diamine tetraacetic acid) series and the like, a polymer of polyvinyl alcohol series, polyvinylpyrrolidone series, polyethylene glycol series and the like, and a phosphate buffer solution; and the anticorrosion system is any combination of sodium azide, gentamicin, amphomycin and ProClin series. The invention further provides a preparation method of the kit. The kit is free from medium effect interference, is used for quality control and evaluation between the detection systems, and more really reflects actual quality conditions of human serum (plasma) samples, which are detected by detection systems.

The invention discloses a method for identifying human blood albumin products, comprising the following steps: (1) a citric acid buffer solution is prepared: 0.2mol / L of citric acid and 0.2mol / L of sodium citrate are taken and mixed according to the volume proportion of 12.3: 7.7, and each liter of buffer solution is added with 100mg of sodium azide, then the pH is adjusted to 4.2 by using 0.2mol / L of citric acid and 0.2mol / L of sodium citrate; (2) a BCG reagent is prepared: 105mg of bromocresol green is weighed and firstly dissolved in 2.5ml of 0.1mol / L NaOH (water-jacket heating for dissolution enhancement), then the mixture is added with 1000ml of 0.2mol / L citric acid buffer solution with the pH of 4.2, and 1 to 2ml of Tween minus 80 is added; (3) 2ml of BCG reagent is taken to be added with one drop of human serum albumin product which is ready to be detected, and an even shaking is carried out. If the color of the solution turns green from yellow, the product is an authentic product; otherwise, the product is a schlock. The identification method of the invention has low analysis cost, no need of special equipment, stronger specificity and high correct rate of the inspection results; the invention is applicable to the rapid inspection method of human blood albumin at the scene, and meets the needs of the basic pharmaceutical supervision and inspection.

The invention discloses an airplane with an abnormal emergency landing safety and protection device, comprising a fuselage, and the backside of the fuselage is provided with a parachute which can pop out of the fuselage when the airplane crashes; the head part and the bottom part of the fuselage are provided with airbag devices which can pop out of the fuselage when the airplane crashes; the airbag device comprises an airbag and a rapidly inflating device; the rapidly inflating device is communicated with the airbag through a pipeline; the pipeline is provided with a check valve; the rapidly inflating device is a nitrogen compressed gas generator or a sodium azide solid tablet gas generator or the combination of the nitrogen compressed gas generator and the sodium azide solid tablet gas generator; the invention can not only reduce the impact when the airplane crashes, but also increase the waterborne buoyancy force of the airplane and improve the safety performance.

The invention discloses a tazobactam synthesis method, which belongs to the technical field of medicines, and includes the steps: firstly, enabling 6,6-dihydropenam sulfoxide acid diphenylmethyl ester serving as raw materials to undergo thermal cracking and chloromethylation reaction to obtain 2beta-chloromethyl penicillanic acid diphenylmethyl ester; secondly, adding oxidizing agent to oxidize the 2beta-chloromethyl penicillanic acid diphenylmethyl ester-1beta-oxide, enabling the oxidized 2beta-chloromethyl penicillanic acid diphenylmethyl ester-1beta-oxide to react with sodium azide to generate 2beta-hydrazoic methyl penicillanic acid diphenylmethyl ester-1beta- oxide, and then generating 2beta-hydrazoic methyl penicillanic acid diphenylmethyl ester-1,1- dioxide by means of oxidization under the action of potassium permanganate and acetic acid; and finally, preparing the tazobactam by means of deprotection under the action of acetylene cyclization and metacresol. Compared with a past 6-APA (aminopenicillanic acid) route, the tazobactam synthesis method has the advantages that the step of sulfur atom single oxidization is added, so that possibility of ring expansion due to affinity of lone pair electrons on a sulfur atom is blocked, and transformation of five-membered ring products to six-membered ring by-products during hydrazoic reaction can be effectively controlled.

A process for chemically synthesizing 1, 2, 3, 4-tetrazolium includes such steps as dissolving zinc trifluoro methylsulfonate in water, adding nitrile and sodium azide, reacting, adding acid for neutralizing and filter. Its advantages are high output rate, and no pollution.

The invention discloses a novel preparation method of netaglinide oxazolone shown in the formula (IV), which comprises the following steps: under the action of a catalyst A, enabling 3-fluorine-4-morpholine phenyl isocyanate shown in the formula (I) to react with (R)-epoxy chloropropane to obtain a compound (II), wherein the catalyst A is magnesium diiodide, magnesium dibromide, magnesium dichloride, magnesium perchlorate or magnesium trifluoromethanesulfonic acid; enabling the compound (II) to react with sodium azide to obtain a compound (III); reducing the compound (III) by hydrogenation, and then, acetylating the reduced compound (III) to obtain the compound (IV). In the invention, the low-cost and environment-friendly catalyst (Lewis acid magnesium) is used for catalyzing the cycloaddition reaction of the (R)-epoxy compound and the isocyanate to establish a mother nucleus structure of the netaglinide oxazolone by one step, thus the prepared netaglinide oxazolone has high stereoselectivity, does not need rigorous operation conditions, such as low temperature, no water, no oxygen and the like, has the advantages of moderate reaction conditions, simple and convenient operation, high utilization ratio of atoms, environment protection, low production cost and the like, and is suitable for industrialized production.

The invention discloses a preparation method of a 1H-1,2,3-triazole compound as shown in a formula (I), which comprises the following steps: mixing halide as shown in a formula (III) with alkyne-terminated compound as shown in a formula (II) and sodium azide, reacting for 5-85 hours at 25-80 DEG C in a reaction solvent under the catalytic action of porous copper; after finishing the reaction, performing after-treatment of the reaction solution to obtain the 1H-1,2,3-triazole compound as shown in the formula (I), wherein the solvent is de-ionized water, acetonitrile, anhydrous ethanol, toluene, acetone, N,N-dimethylformamide, tetrahydrofuran or dioxane. The preparation method provided by the invention adopts one-pot operation, the catalyst can be reused for multiple times, the reaction condition is mild, and the operation is easy and simple.

The invention relates to a method in which atom transfer radical polymerization (ATRP) and 'click' mistry are comprehensively utilized to improve surface hydrophilism of the polyurethane material, specifically, polyvinyl pyrrolidone is grafted on the surface of the polyurethane material to obtain surface functional polyurethane material. The invention aims to provide a simple and practical method for modifying the polyurethane surface and obtaining required high-degree wettability. The method comprises the following steps: first, vinyl pyrrolidone monomer is polymerized to obtain polyvinyl pyrrolidone (Init-PVP-X, X=CI, Br) with a terminal group thereof being halogen atom through the atom transfer radical polymerization reaction, then sodium azide is employed to convert the terminal group of the polyvinyl pyrrolidone from chlorine or bromine to triazon. with the method of the invention, surface hydrophily of high polymer material polyurethane with excellent mechanical properties can be noticeably improved and the question that the PVP combines with polyurethane is solved, so that a novel polyurethane function material featuring simple technology and economy and practicability is formed.

The invention discloses a preparation method of a compound 2-[4-((3S)-3-piperidin) phenyl]-2H-indazole-7-carboxamide; through the reaction of 4-nitryl phenylpyridine and benzyl halides, the benzyl quaternary ammonium salt is generated; the pyridine quaternary ammonium salt is restored selectively through sodium borohydride; under the effect of palladium reagent, the 3-(4- aminophenyl)- piperidine is obtained the (S)-3-(4- halogenated phenyl) piperidine is obtained through manually splitting the reagent, and then condensed with 3- formyl group-2- nitrobenzene methyl benzoate and forms pyrazol ring under the effect of sodium azide; through aminolysis, the Niraparib (molecule entity is: 2-[4-((3S)-3-piperidin) phenyl]-2H-indazole-7-carboxamide) is prepared.

A device and method device for delivering a fire suppressing gas to a space is provided. The device includes a housing disposed within the space; at least one generator disposed within the housing and containing pre-packed sodium azide based propellant; an ignition device for igniting said sodium azide based propellant and thereby generating a low-moisture fire suppressing gas; and an opening in the housing for directing the fire suppressing gas mixture into said space.

The invention discloses a method for synthesizing oseltamivir phosphate without using nitrine. The method comprises the following steps of: sequentially performing an epoxy ring-opening reaction, a hydroxyl acylation reaction, an intramolecular substitution reaction for ring formation, a selective ring-opening reaction, a reaction for removing tertiary-butyl and a phosphoric acid salt forming reaction on a raw material namely (3R, 4R, 5S)-4,5-epoxy-3-(1-ethyl-propoxy)-1-cyclohexene-1-ethyl ester carboxylate to obtain a product namely oseltamivir phosphate. The method is safe and high in efficiency and yield; compared with the prior art, the method has the biggest advantage that toxic explosive chemicals such as sodium azide and trimethyl-phosphine are not used, and is rich in raw material source and capable of performing large-scale production, so that the method can better meet requirements for strategic reserve of medicaments for preventing and treating bird flus by all human beings.

The invention belongs to the technical field of organic-inorganic composite materials and analysis, particularly relates to a hydrophilic magnetic mesoporous microsphere and a production method and application thereof. The production method includes (1) taking a surfactant as a structure-directing agent through sol-gel reaction, and coating a layer of functionalized silica / surfactant composite materials with ordered mesostructure on surfaces of magnetic layer inorganic nanoparticles; (2) removing the surfactant through solvent extraction, and acquiring surface-functionalized magnetic mesoporous microspheres; (3) acting with sodium azide to acquire azide magnetic mesoporous microspheres; and (4) utilizing click chemistry reaction to allow alkynyl saccharides to act with the azide magnetic mesoporous microspheres, and acquiring hydrophilic magnetic mesoporous microspheres. The hydrophilic magnetic mesoporous microspheres have the advantages of good magnetic induction, strong specificity and the like, and have good using value and application prospect in the field of proteomics and the like.

The invention discloses a kit for determining glycosylated hemoglobin and a preparation method thereof. The kit comprises three liquid components a reagent R1, reagent R2 and a reagent R3 that are independently to each other. The reagent R1 consists of: a latex glycine buffer solution, polyethylene glycol-2000, Tween-80, glycerin, bovine serum albumin, and sodium azide, the reagent R2 consists of: a glycine buffer solution, an anti-IgG antibody, an anti-HbA1c antibody, sodium chloride, bovine serum albumin and sodium azide, and the reagent R3 consists of: a hemolysin diluent. The preparation method includes: preparing the reagents according to the component content; mixing a to-be-determined sample with the reagent 3, and using the hemolysin diluents to treat the to-be-determined sample; mixing the treated to-be-determined sample with the reagent R1 and reagent R2 and carry out full reaction; employing a fully automatic biochemical analyser to determine the absorbance difference after reaction; and calculating the concentration of glycosylated hemoglobin in the sample according to an absorbance change value. The kit provided by the invention has the advantages of high accuracy, and convenient operation, etc.

The present invention is directed to an airbag system that includes a gas generant, which is improved in the defects of gas generants using sodium azide in a practical use and has stable combustion capability. A molecular compound comprising (a) a gas generant component, (b) an oxidant component and (c) a reaction accelerator component, preferably represented by the composition formula (I).M.mX.nY(I)is disclosed

Production of 2-octyl-3,4-di(7-isocyanate caprylic)-1-hexyl cyclohexane and fatty isocyanate containing it is carried out by hydrogenation catalyzing for dimmer acid between room temperature to 280 deg. C, dewatering for generated saturated dimmer acid, reacting with sulfurous chloride, reacting dimeric acid acyl bromide with sodium azide to generate dimeric acid azide, isomerization decomposing to convert into final product. It can be used to produce polyurethane varnish, elastomer, adhesive, spinning finishing agent and rocket impeller.

The present invention discloses a rheumatoid factor detection reagent, which comprises a reagent R1 and a reagent R2, wherein the reagent R1 comprises a phosphate buffer solution, lauryl imidazolinium betaine, dioctadecyl dimethyl ammonium chloride, dodecyl trimethyl ammonium chloride, alkyl phenol ethoxylates (APEO), 1-hydroxyethylidene-1,1-diphosphonic acid, sodium azide and a stabilizer SHE-50, and the reagent R2 comprises a phosphate buffer solution, thermal polymerization I human IgG, latex microspheres, Kathon-CG, alkyl phenol ethoxylates (APEO) and sodium azide. According to the present invention, a variety of the reagents in the detection reagent of the present invention provide the synergy effect, and the detection reagent has characteristics of good accuracy, good stability, wide linear range, cheap price and easy use, and can completely meet the clinical needs.

The invention provides a diluent for a blood cell analyzer. The diluent consists of edentate, sodium sulfate, sodium chloride, dimethylol urea, biological buffer, a betain type nonionic surfactant, sodium azide and water. The diluent solves the problems that the osmotic pressure of a bottom layer is higher than that of an upper layer and the solution is not uniform or stable when the diluent for the blood cell analyzer stands for a long time.

The invention relates to a detection kit for a retinol binding protein. The interior of a detection kit body comprises reagents R1 and reagents R2, wherein the reagents R1 comprise a buffer solution, polyethylene glycol, sodium azide, sodium ethylene diamine tetracetate and bovine serum albumin; and the reagents R2 comprise a buffer solution, latex grains combined with retinol binding protein monoclonal antibodies, tween-20, sodium azide, sodium ethylene diamine tetracetate and bovine serum albumin. A sample and the reagents are mixed at a certain volume ratio and generate a series of reactions, and then a reactant is placed under a semi / full-automatic biochemical analyzer, and the speed of absorbance change in the position of a main wavelength of 340nm is detected, so that the concentration magnitude of the retinol binding protein is measured and calculated. The detection kit has the advantages of accuracy, stability and convenience.

The invention discloses polymer mixed type grafted nano silicon dioxide, a PVDF (Polyvinylidene Fluoride) microfiltration membrane and application thereof. A preparation method of the silicon dioxide comprises the following steps: taking nano silicon dioxide and an amino silane coupling agent to react to obtain amino silicon dioxide; adding an acid capturing agent; dropwise adding bromoalkylacyl bromide under an ice water bath condition; after reacting, obtaining bromo silicon dioxide; adding sodium azide and reacting to obtain silicon dioxide azide; finally, adding a mixture of an alkynyl-containing hydrophilic polymer and an alkynyl-containing hydrophobic polymer, copper sulfate and sodium ascorbate; reacting to prepare the polymer mixed type grafted nano silicon dioxide. Polymer chain segments easy to mix with the PVDF on the surfaces of modified silicon dioxide particles can fix silicon dioxide after film formation, so that the obtained hydrophilic modified microfiltration membrane has very good durability; furthermore, the modified silicon dioxide enables a polymer membrane to automatically form an asymmetric structure in an oil-containing wastewater treatment process, so that the polymer membrane has an efficient oil-water separation performance.

The invention discloses a ratiometric fluorescent probe for detection of hydrogen sulfide and a preparation method of the ratiometric fluorescent probe. A compound of the probe is 2-(6-azido-1,3-dioxo-benzoisoquinolinyl)ethyl 2-(4-((4-(1,2,2-triphenylvinyl)phenoxy)methyl)-1,2,3-triazolyl)ethyl)succinate. During the preparation, 4-bromo-1,8-naphthalic anhydride is reacted with 2-aminoethanol to obtain a solid, namely, 6-bromo-2-(2-hydroxyethyl)-benzoisoquinoline-dione, the product is reacted with sodium azide to obtain a solid, namely, 6-azido-2-(2-hydroxyethyl)-benzoisoquinoline-dione; and then 6-azido-2-(2-hydroxyethyl)-benzoisoquinoline-dione is subjected to a series of reaction to obtain the solid probe compound. The probe compound is composed of hydrophobic tetraphenylvinyl and hydrophilic receptor units containing azide group and can be used for quantitative analysis of hydrogen sulfide in chemical, biological, environmental and other samples.