The invention discloses a
metal chelate which takes plumbagin as ligand, and the synthesis method and application thereof. The
metal chelate is represented by the right formula, wherein, M represents the
metal ion able to accept
lone pair electrons can be main group matel
ion, or
transition metal ion, or
rare earth metal ion such as Ca(II), Mg(II), Sn(IV), Cu(II), Co(II), Ni(II), Zn(II), Fe(II), Mn(II), Ag(I), Mo(VI), Pd(II), Ru(III), W(VI), Pt(II), Y(III), La(III), Nd(III), Sm(III), Eu(III), Er(III). The invention synthesizes a series of
metal chelate which takes plumbagin as ligand and reacts with the metal salt. The produced chelate has an inhibition to a plurality of tumor line. The result indicates a plurality of chelate having a more remarkable anti-tumor activity than the plumbagin and have a higher
medicine value and can be used for the preparation of different anti-tumor
medicine.