Flurbiprofen liposome and preparation method thereof

Abstract

The invention relates to a flurbiprofen liposome and a preparation method thereof. The flurbiprofen liposome is prepared by weighting the following materials in part by weight: 1 to 10 parts of cholesterol, 5 to 40 parts of yolk lecithin, 2 to 50 parts of flurbiprofen and 1 to 10 parts of vitamin C; dissolving the materials with chloroform and methanol in a mass ratio of 4:1; uniformly mixing the materials to obtain mixed solution; putting the solution into a rotary evaporator; distilling the solution under reduced pressure for removing the chloroform and the methanol to obtain a lipid membrane; adding phosphate buffer with pH between 6 and 8 into the lipid membrane; rotating for 1 to 4 h in warm bath at the temperature of between 20 and 60 DEG C on the rotary evaporator; and carrying out water bath ultrasound for 5 to 30 min, and then filtering the mixture with a 0.22 to 0.45 mu m filter membrane to obtain the flurbiprofen liposome. The flurbiprofen liposome prepared by the invention has good stability, targeting property and slow-releasing property, can reduce administration dosage and reduce toxic and side effect of medicaments, is suitable for percutaneous administration and oral administration, and can be widely used for preparing oral liquid, aerosol, spray, and ophthalmic and external liposome administration formulations.

Description

technical field [0001] The invention relates to a flurbiprofen liposome and a preparation method thereof. It belongs to the technical field of pharmaceutical preparations. Background technique [0002] Flurbiprofen is one of the excellent varieties of non-steroidal anti-inflammatory analgesics, mainly used for the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, traumatic pain and other pains. Flurbiprofen acts as an anti-inflammatory and analgesic by inhibiting the activity of prostaglandin synthase cyclooxygenase. The drug is effective orally and well tolerated, and long-term use neither promotes nor inhibits its own metabolism. Although flurbiprofen has unique anti-inflammatory and analgesic effects clinically, flurbiprofen is a lipophilic drug with low solubility in water, resulting in low oral bioavailability and serious gastrointestinal and central nervous system damage. Systemic adverse reactions. At present, most of the reports about flu...

AI Technical Summary

Problems solved by technology

Although flurbiprofen has unique anti-inflammatory and analgesic effects clinically, flurbiprofen is a lipophilic drug with low solubility in water, resulting in low oral bioavailability and serious gastrointestinal and central nervous system damage. Systemic adverse reactions