Flurbiprofen axetil microsphere preparation

Abstract

The invention provides a flurbiprofen axetil microsphere preparation, a preparation method and an application thereof. The plurbiprofen axetil microsphere preparation comprises flurbiprofen axetil, an oil phase solvent and chitosan and / or derivatives thereof and an emulsifying agent. The method for preparing the flurbiprofen axetil microsphere preparation comprises the following steps of: (1) mixing oil phase mixture containing the flurbiprofen axetil, the oil phase solvent and the emulsifying agent so as to produce a uniform oil phase; (2) mixing aqueous phase mixture containing chitosan and / or the derivatives thereof and water so as to form a uniform aqueous phase; (3) adding the oil phase into the aqueous phase so as to form initial emulsion; and (4) homogenizing the initial emulsion. The invention further provides an application of the flurbiprofen axetil microsphere preparation to be used for preparing analgesic or anti-inflammatory drugs.

Description

A kind of flurbiprofen axetil lipid microsphere preparation technical field The invention belongs to the field of pharmaceutical preparations, in particular to a flurbiprofen axetil lipid microsphere preparation containing chitosan or derivatives thereof. Background technique The chemical name of flurbiprofen axetil is (±)2-(2-fluoro-4-biphenyl)propionate-1-acetoxyethyl ester, which is a non-steroidal analgesic prodrug. The prodrug's active product, flurbiprofen, is a cyclooxygenase (COX) inhibitor. Flurbiprofen, as a non-steroidal anti-inflammatory drug (NSAID), has anti-inflammatory and analgesic effects, and is clinically used for the treatment of pain or inflammatory diseases. Most of the commercially available preparations of flurbiprofen are oral agents, such as flurbiprofen tablets, flurbiprofen sustained-release tablets and the like. Since it has been found that oral administration of flurbiprofen is easy to cause adverse reactions such as gastrointestinal disor...

AI Technical Summary

Problems solved by technology

However, the existing flurbiprofen axetil liposphere injection will be affected by factors such as raw materials, preparation conditions and storage conditions in the process of preparation and storage, so there are stability problems. Demulsification and delamination may occur during high-temperature sterilization or storage, which will affect the clinical use of the preparation

In addition, the drug tissue targeting of this existing preparation also needs to be enhanced

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