The invention discloses a low-melting-point compound suspension. The low-melting-point compound suspension comprises the following components in parts by weight: 5 to 55 parts of a low-melting-point compound, 1 to 7 parts of a moisturizing agent, 2 to 5 parts of a dispersant, 0.5 to 3 parts of a stabilizing agent, 2 to 6 parts of an anti-freezing agent, 0.1 to 0.5 part of a preservation, 1 to 8 parts of a thickening agent, 0.1 to 0.5 part of an anti-foaming agent, 1 to 15 parts of a special auxiliary agent, and the balance of water; the low-melting-point compound is a compound with the melting point between 35 and 70 DEG C; the auxiliary agent comprises the following components in parts by weight: 8 to 40 parts of isooctyl alcohol polyoxyethylene ether, 8 to 30 parts of calcium dodecyl benzene sulfonate, 6 to 20 parts of dioctyl sodium sulfosuccinate, 6 to 18 parts of octanol, and 3 to 5 parts of liquid paraffin. The invention also discloses a preparation method for the suspension. The preparation method comprises the following steps: mixing uniformly, grinding, adding the thickening agent and stirring uniformly. The low-melting-point compound suspension is high in fluidity, obvious in medicinal effect, easy to prepare, and low in production cost.