39results about How to "Improve oral glucose tolerance" patented technology

The invention relates to a mactra veneriformis extract which is prepared by the following method of taking the soft body part of the mactra veneriformis as a material, washing and grinding the material, adding water for decoction, filtering, then obtaining water decoction extracting solution, centrifuging the water decoction extracting solution,collecting supernatant fluid, concentrating, cooling,then adding ethanol for precipitating, filtering, obtaining an ethanol precipitate, drying and then obtaining the mactra veneriformis extract; and deproteinizing the mactra veneriformis extract to obtain purified mactra veneriformis extract which has glycemia-reducing, immune adjusting and liver-protecting functions. The invention also discloses the applications of the mactra veneriformis extracton preparation of medicaments or health care products simultaneously.

The invention provides floccularia luteovirens polysaccharide as well as a preparation method thereof and a medical use thereof in controlling diabetes. Crude polysaccharide obtained by water extraction and alcohol precipitation of floccularia luteovirens is subjected to protein removal to obtain any one or more of floccularia luteovirens total sugar, floccularia luteovirens protein composite, floccularia luteovirens polysaccharide or purified homogeneous polysaccharide component. According to the animal experiment, the floccularia luteovirens polysaccharide can reduce bodyweight growth speedof a db / db mouse, reduces fasting blood-glucose of a diabetic mouse, improves oral glucose tolerance, and has good activity of reducing blood fat, resisting oxidization and resisting inflammation. Thefloccularia luteovirens polysaccharide is taken as a natural product obtained from an edible and medicinal fungus resource, is small in toxic and side effect, has remarkable effects of resisting oxidative stress and inflammation, realizing the effects of resisting type 2 diabetes and renal complications, further can be used for developing medicines and healthcare products for safely and effectively preventing, alleviating or treating type 2 diabetes and renal complications caused by diabetes, and has an extremely high edible value, an extremely high medical value and an extremely high economical value.

The invention discloses the application of Bifidobacterium adolescentis CCFM1061 in the preparation of functional bacterial agents, foods and or medicines. Bifidobacterium adolescentis CCFM1061 can quickly colonize the intestinal tract and significantly improve the risk of type 2 diabetes induced by STZ and high-fat diet. Fasting blood glucose, oral glucose tolerance, reduce the area under the curve of glucose tolerance; significantly improve the increase of total cholesterol in serum and the decrease of high-density lipoprotein cholesterol in type 2 diabetes caused by STZ and high-fat diet; can significantly improve insulin in type 2 diabetes Resistance; can significantly improve the level of inflammation in type 2 diabetes liver tissue; significantly improve the pathological damage of type 2 diabetes pancreas, liver and other tissues. In addition, Bifidobacterium adolescentis CCFM1061 has a strong adsorption capacity for perfluorooctanoic acid (PFOA), and has the ability to alleviate the toxicity of PFOA.

The invention discloses Bifidobacterium bifidum CCFM1063 and its application. Bifidobacterium bifidum CCFM1063 can quickly colonize the intestinal tract, significantly improve fasting blood sugar and oral glucose tolerance caused by type 2 diabetes, and reduce the area under the curve of glucose tolerance; Significantly improve the increase of total cholesterol and decrease of high-density lipoprotein cholesterol caused by type 2 diabetes; significantly improve the insulin resistance caused by type 2 diabetes; significantly improve the level of inflammation in liver tissue of type 2 diabetes; significantly improve the level of inflammation caused by type 2 diabetes Bifidobacterium bifidum CCFM1063 has a strong adsorption capacity for perfluorooctanoic acid, and has the ability to alleviate the toxicity of perfluorooctanoic acid; it can significantly improve the constipation caused by type 2 diabetes and increase the level of Allobaculum in the intestine , has the effect of relieving anxiety, depression and colitis.

The present invention is the new function of chitobiose and its application in health food. The chitobiose is a degradation product of chitin, and is an oligosaccharide formed by connecting two N-acetylglucosamines with glycosidic bonds. Animal experiments show that the chitobiose has obvious α-glucosidase inhibitory activity, and its IC50 is 2.0mg / mL, which can significantly reduce the fasting blood glucose level of type II diabetic mice, the lowest to 6.1mg / mL, which is significantly lower than The fasting blood glucose value of the control acarbose group was 7.9mg / mL, which was close to the upper limit of the fasting blood glucose value range of normal healthy mice. Second, compared with acarbose, chitobiose can significantly reduce serum lipid levels and inhibit pancreatic lipid peroxidation. In addition, chitobiose can stabilize the body weight of diabetic mice. The compound of chitobiose and xylooligosaccharide also has obvious hypoglycemic effect. The chitobiose of the present invention has a good hypoglycemic effect, and can be used to develop a safe and effective health food for preventing and improving type II diabetes.