Lactobacillus rhamnosus CCFM0528 having diabetes preventing effect

Abstract

The invention relates to lactobacillus rhamnosus CCFM0528 having an inhibitory effect on alpha-glucosidase activity, the bacterial strain is preserved at the China General Microbiological Culture Collection Center (CGMCC), and the accession number is CGMCC No.7317. Cytoplasm and fermentation supernate of the CCFM0528 can respectively exhibit the inhibitory effects on the alpha-glucosidase activity, with the inhibition rates of 29.2% and 14.1% respectively. Studies show that the CCFM0528 exhibits the inhibitory effect not only on the alpha-glucosidase activity, also on glucose transport. The experimental results show that the CCFM0528 can prevent type-2 diabetes, effectively reduce fasting blood glucose and postprandial blood glucose of mice, and improve glucose tolerance of the mice. The principle may be that the CCFM0528 has inhibitory effect on the alpha-glucosidase activity and enzyme expression amount in intestinal tract, and can influence the gene expression level of glucose-transport relating protein SGLT-1 and GLUT-2.

Description

technical field [0001] The invention relates to the field of microorganisms in the field of biotechnology, in particular to Lactobacillus rhamnosus CCFM0528 which has the effect of preventing diabetes. technical background [0002] According to the definition released by the World Health Organization (WHO) and the International Diabetes Federation (IDF) in 1999, it is mainly divided into insulin-dependent diabetes mellitus (type 1, DIDM) and non-insulin-dependent diabetes mellitus (2 NIDDM), other types and four types of gestational diabetes, of which type 2 diabetes accounts for more than 90%. In recent years, diabetes has become widespread all over the world, and has become the third chronic disease that seriously endangers human health after tumors and cardiovascular diseases. The prevalence of diabetes in my country has increased by four times in the past 20 years. In 2007, the number of diabetic patients in China was 39.8 million, second only to India as the country wi...

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At present, a large number of studies have shown that lactic acid bacteria have the potential to reduce the inci

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