124 results about "Serum lipid levels" patented technology

The present invention relates to a micro-particle for extending satiety and controlling blood glucose and lipid levels, comprising a core having the protein extract from sweet potato, an active ingredient layer coated on the core, and a protection layer coated over the active ingredient layer as an external layer, wherein the protein extract from sweet potato contains trypsin inhibitor and glycoprotein. The micro-particle comprising a protein extract from sweet potato can effectively extend satiety, control blood glucose and lipid levels and increase metabolism effectively.

The invention discloses a composition of probiotic fermented horseradish tree leaves as well as a preparation method and application of the composition. The preparation method comprises the following steps: crushing and immersing horseradish tree leaves; adding glucose, peptone, yeast extract, yeast powder and inorganic salt into an immersing solution; extracting at a high pressure; and after carrying out probiotic fermentation and centrifuging, adding polydextrose and fructo-oligosaccharide syrup and sterilizing to obtain the composition of the probiotic fermented horseradish tree leaves. The composition can be used for preparing health products, foods and beverages capable of lowering blood fat and improving a sleeping function. An experiment shows that the composition of the probiotic fermented horseradish tree leaves can be used for reducing the contents of total cholesterol (TC) and triglyceride (TG) in blood serum, and improving the content of high density lipoprotein cholesterol (HDL-C) in the blood serum; the composition of the probiotic fermented horseradish tree leaves, disclosed by the invention, has a function of lowering a blood fat level.

Disclosed herein are methods, compounds and compositions for preventing or treating a pancreatic disorder, including diabetes mellitus (e.g. type 1 and/or type 2 diabetes). The invention generally includes administering to a subject 1,3-propanedisulfonic acid or a pharmaceutically acceptable salt thereof, e.g., 1,3-propanedisulfonic acid sodium salt. The invention also relates to methods, compounds and compositions for improving or at least stabilizing pancreatic function(s) and for the prevention and/or treatment of metabolic syndrome and its components. The invention further relates to methods, compounds and compositions for the prevention and/or treatment of dyslipidemia, and more particularly for reducing levels of harmful serum lipid levels, especially cholesterol and triglycerides in patients in need thereof, including diabetic patients.

A pharmaceutical composition is an organic salt formed by an organic acid rosuvastatin and an organic base azelnidipine with a molar ratio of 1:1. The pharmaceutical composition can be made into any dosage forms together with a pharmaceutically-acceptable carrier for reducing blood pressure and blood lipid, reducing myocardial infarction and treating cerebral apoplexy. The inventive pharmaceutical composition has the advantages of stable physiochemical indexes, controllable product quality, and convenient administration.

A water-like fluid containing safe water and a significant quantity of soluble dietary fiber. The resulting solution is generally optically clear and has physical properties similar to potable water. The fluid is intended as a replacement for bottled, or other water, as a means to ensure proper hydration. Depending on the soluble fiber used the fluid is either non-caloric or extremely low in calories. The amount of soluble fiber is adjusted to a specific amount of water so that consumption of an adequate amount of fluid ensures hydration (e.g., eight 8 oz. glasses per day) will also providing an optimal amount of dietary fiber. This is particularly valuable in stressed situations where the diet may not provide adequate fiber without supplementation. The constant metered supply of fiber provided throughout the day is preferable to, and more convenient than, “bolus” administration of fiber through laxatives, etc. Additionally, the constant presence of soluble fiber in the digestive tract provides the known beneficial effects of moderating the postprandial increase in blood glucose, modulating serum lipid levels, and suppressing appetite.

The invention discloses a lotus leaf-based preparation for treating phlegm and blood stasis simultaneously. The pharmaceutical composition is prepared from the following traditional Chinese medicine extracts in parts by weight: 40-80 parts of lotus leaf extract, 10-20 parts of salvia miltiorrhiza extract, 30-60 parts of hawthorn extract, 10-20 parts of malaytea scurfpea fruit extract or salt scurfpea fruit extract, and 1-3 parts of senna extract. The invention further discloses application of the lotus leaf-based preparation in the preparation of medicines for treating phlegm turbidity and blood stasis simultaneously. The lotus leaf-based preparation disclosed by the invention has the activity in lowering blood lipid levels, and can be used for treating phlegm and blood stasis simultaneously and lowering the blood lipid levels.

Disclosed herein are methods, compounds and compositions for preventing or treating a renal disorder or chronic kidney diseases, including nephropathies such as diabetic nephropathy. The invention generally includes administering to a subject 1,3-propanedisulfonic acid or a pharmaceutically acceptable salt thereof, e.g., 1,3-propanedisulfonic acid sodium salt. The invention also relates to methods, compounds and compositions for the prevention and/or treatment of for preventing or treating a renal disorder complication. The invention further relates to methods, compounds and compositions for the prevention and/or treatment of dyslipidemia, and more particularly for reducing levels of harmful serum lipid levels, especially cholesterol and triglycerides in diabetic patients.

The invention discloses a citrus chachiensis hortorum polymethoxylated flavonoids effective part and application thereof for treating hyperlipidaemia. The effective part is prepared from the following steps: step S1, extracting: grinding the citrus chachiensis hortorum, extracting by use of an alcohol-water solution, concentrating; step S2, removing impurities; sampling the concentrated solution obtained in the step S1 on macroporous resin, eluting and removing impurities by use of an ethanol water solution with the volume percent concentration of 40-45%, wherein the model of the macroporous resin is D101 type; and step S3, eluting: eluting the macroporous resin by use of the ethanol water solution with the volume percent concentration of 90% or more, collecting eluent, concentrating to obtain the citrus chachiensis hortorum polymethoxylated flavonoids effective part. The citrus chachiensis hortorum polymethoxylated flavonoids effective part provided by the invention can effectively lower the blood lipid level of hyperlipidaemia model mice, and is non-toxic, safe and effective, and can be used for preventing or treating hyperlipidaemia.

The invention relates to application of diosmetin in preparation of a medicine used for treating type 2 diabetes mellitus. Researches show that diosmetin can obviously improve glycometabolism of the type 2 diabetes mellitus, can improve insulin level and lower blood lipid level, can be used for preparing a blood-glucose-lowering medicine and provides a new medicine for treatment of the type 2 diabetes mellitus, thereby having significance on the treatment of diabetes mellitus.

Quinoline and quinoxaline compounds of formula I and III, wherein the substituents are as defined in claims 1 and 15, pharmaceutical compositions comprising these compounds and these compounds are effective in raising certain plasma lipid levels, including high-density lipoprotein cholesterol As well as the application of lowering certain other blood lipid levels such as LDL-cholesterol and triglycerides, thus for the treatment of diseases caused by abnormalities of low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides in mammals, including humans, such as Atherosclerosis and cardiovascular disease.

A water-like fluid containing safe water and a significant quantity of soluble dietary fiber. The resulting solution is generally optically clear and has physical properties similar to potable water. The fluid is intended as a replacement for bottled, or other water, as a means to ensure proper hydration. Depending on the soluble fiber used the fluid is either non-caloric or extremely low in calories. The amount of soluble fiber is adjusted to a specific amount of water so that consumption of an adequate amount of fluid ensures hydration (e.g., eight 8 oz. glasses per day) will also providing an optimal amount of dietary fiber. This is particularly valuable in stressed situations where the diet may not provide adequate fiber without supplementation. The constant metered supply of fiber provided throughout the day is preferable to, and more convenient than, 'bolus' administration of fiber through laxatives, etc. Additionally, the constant presence of soluble fiber in the digestive tract provides the known beneficial effects of moderating the postprandial increase in blood glucose, modulating serum lipid levels, and suppressing appetite.

The invention provides a method for extracting saffron petal total polysaccharide, belonging to the technical field of saffron active ingredient extraction. The method comprises the following steps: the saffron petal is extracted with ethanol and air-dried and the filter residue is mixed with water at a ratio of 1 g to (15 to 25) ml and then extracted at 95-105 DEG C for 3 hours, and then alcoholprecipitation is carried out to obtain a saffron petal total polysaccharide crude product; the saffron petal total polysaccharide crude product is redissolved and subjected to chromatographic purification by chromatography column so as to obtain the saffron petal total polysaccharide. The method disclosed by the invention has high saffron petal total polysaccharide yield, high activity, high DPPHfree radical and .OH scavenging ability. The acute toxicity evaluation is practically non-toxic, which can reduce the contents of TC and TG in the liver to certain extent. The saffron petal polysaccharide is indicated to have the functions of lowering blood lipid levels, effectively preventing high blood lipid levels, and effectively preventing hyperlipidemia caused by long-term high-fat diet.

The invention provides a blood lipid level related single nucleotide polymorphism rs4883263 detecting system and related application, particularly determines relevance between single nucleotide polymorphism rs4883263 and blood lipid level, provides application of reagent materials and/or instruments for detecting polymorphism of a rs4883263 locus in a sample of a to-be-tested individual to preparation of a detecting system for assessment of blood lipid level and/or dyslipidemia risks, and further provides the detecting system for assessment of the blood lipid level and/or the dyslipidemia risks. The detecting system comprises the reagent materials and/or instruments for detecting polymorphism of the rs4883263 locus in the sample of the to-be-tested individual, wherein rs4883263 is remarkably related to HDL-C level, and rs4883263 locus C allele carriers are lower in HDL-C level and higher in dyslipidemia risks than non-carriers.

The invention relates to the technical field of biology and relates to treatment of type 2 diabetes mellitus with gene modified MSCs. The invention provides a recombinant stem cell which can overexpress an Exendin-4 protein. Medicines for treating obesity, fatty liver and type 2 diabetes mellitus can be prepared by utilizing the recombinant stem cell. The recombinant stem cell can be used for remarkably reducing the level of blood glucose and blood lipids and promoting the sensitivity of insulin. The treatment effect can be maintained for one month or more after a course of treatment, and therecombinant stem call can be used for treating metabolic diseases including obesity, fatty liver and type 2 diabetes mellitus, is safe and effective and has a long acting time.