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284 results about "Dysostosis" patented technology

A dysostosis is a disorder of the development of bone, in particular affecting ossification. Examples include craniofacial dysostosis, Klippel–Feil syndrome, and Rubinstein–Taybi syndrome. It is one of the two categories of constitutional disorders of bone (the other being osteochondrodysplasia).

HBM variants that modulate bone mass and lipid levels

The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
Owner:WYETH +1

Medicine controlled functional cement with calcium phosphate being as framework and its preparation method

A calcium phosphate cement with the function of controlling medicine release for repairing dysostosis, treating osteomyelitis and preventing infection and recurrence of osteoma is prepared from porous calcium phosphate cement and medicine capsules containing antibacterial medicine, antineoplastic medicine, anti-flammatory antalgic medicine, antituberculosis, etc. Its advantages are slow medicinesreleasing, and high curative effect.
Owner:EAST CHINA UNIV OF SCI & TECH

Regulation of transforming growth factor-beta (TGF-beta) gene expression in living cells via the application of specific and selective electric and electromagnetic fields

Methods and devices are described for the regulation of Transforming Growth actor (TGF)-β1, β2, and / or β3 protein gene expression in bone cells and other tissues via the capacitive coupling or inductive coupling of specific and selective electric fields to the bone cells or other tissues, where the specific and selective electric fields are generated by application of specific and selective electric and electromagnetic signals to electrodes or one or more coils or other field generating device disposed with respect to the bone cells or other tissues so as to facilitate the treatment of diseased or injured bone and other tissues. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased bone and other tissue that include generating specific and selective electric and electromagnetic signals that generate fields in the target tissue optimized for increase of TGF-β1, β2, and / or β3 protein gene expression and exposing bone and other tissue to the fields generated by specific and selective signals so as to regulate TGF-β1, β2, and / or β3 protein gene expression in such tissue. The resulting methods and devices are useful for the targeted treatment of bone fractures, fractures at risk, delayed unions, nonunion of fractures, bone defects, spine fusions, osteonecrosis or avascular necrosis, as an adjunct to other therapies in the treatment of one or all of the above, in the treatment of osteoporosis, and in other conditions in which TGF-β1, β2, and / or β3 protein may be implicated.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA

Automated Vertebral Body Image Segmentation for Medical Screening

A method Is disclosed for fully automated segmentation of human vertebral body images in a CT (computerized tomography) study with no user interaction and no phantoms, which has resiliency to, anatomical abnormalities, and protocol and scanner variations. The method was developed to enable automated detection of osteoporosis in CT studies performed for other clinical reasons. Testing with 1.044 abdominal CTs from multiple sites, resulted in detection of 96.3% of the vertebral, bodies and 1% false positives. Of the detected vertebral bodies, 83.3% were segmented adequately for sagittal plane quantitative evaluation of vertebral, fractures indicative of osteoporosis. Improved results were observed when selecting the best sagittal plane of 3 for each vertebra, yielding a segmentation success rate of 85.4%. The method is preferably implemented in software as a building block in a system for automated osteoporosis detection.
Owner:RADNOSTICS

Health care formulation for improving osteoporosis of female in middle and old age and preparation method thereof

The invention relates to a health-cared preparation for improving the osteoporosis of middle and old aged women, and a preparation method thereof. The method mainly takes calcareous compounds such as soy isoflavones and calcium carbonate, eucommia bark or folium cortex eucommiae, psoralea fruit, calcium absorption accelerator, for example, caseinophospho peptides or vitamin D3, and bone joint protective agents, for example, chondroitin sulfate or D-glucosamine as raw materials; and the health-cared preparation is prepared according to a certain weight ratio. The raw materials are combined together so that the effects generate synergic action, the absorption of the human body to the calcium is effectively promoted, and the bone conditions are improved. The product has the effects of tonifying the liver and kidney, strengthening the muscles and bones, supplementing the calcium source and improving the osteoporosis of the middle and old aged women.
Owner:JIANGXI HERBFINE HI TECH

Chinese traditional medicine prescription for treating osteoporosis

InactiveCN101112445AComprehensive curative effectRealize the purpose of western medicine calcium supplementationSkeletal disorderPlant ingredientsOysterRhizome
The present invention relates to a compound preparation in the field of traditional Chinese medicine, in particular to a drug formulation for treating osteoporosis. The present invention includes the following raw materials with the parts by weight: 200 to 1200 parts of radix rehmanniae preparata, 100 to 600 parts of desertliving cistanche, 50 to 500 parts of epimedium herb, 100 to 600 parts of Chinese pyrola herb, 100 to 600 parts of fortune's drynaria rhizome, 100 to 600 parts of himalayan teasel root, 100 to 600 parts of east Asian tree fern rhizome, 100 to 600 parts of eucommia bark, 100 to 1200 parts of membranous milkvetch root, 50 to 500 parts of angelica, 100 to 1000 parts of tuber fleeceflower root, 100 to 1000 parts of suberect spatholobus stem, 100 to 600 parts of Chinese taxillus twig, 50 to 600 parts of Chinese clematis root, 100 to 600 parts of largehead atractylodes rhizome, 50 to 600 parts of twotooth achyranthes root, 100 to 600 parts of barbary wolfberry fruit, 100 to 600 parts of cornu cervi degelatinatum, 100 to 600 parts of medicinal indianmulberry root, 50 to 400 parts of liquoric root and 200 to 2000 parts of oyster. The traditional Chinese medicine preparation of the present invention mainly cures kidney and liver insufficiency, malnutrition of bones and tendons and blood stasis blocking syndromes; and the syndromes are pains at the waist and the back, weak legs and pains etc. The present invention is mainly applicable to the people with the symptoms of osteoporosis. The present invention has reliable efficacy and no adverse reactions, which is proved by the clinical applications.
Owner:毛继凯

Diuretic Compounds Comprising Heterocyclic Nitric Oxide Donor Groups, Compositions and Methods of Use

InactiveUS20080275093A1Improve propertiesBiocideNervous disorderRenovascular diseaseFuroxan
The invention describes novel diuretic compounds comprising at least one heterocyclic nitric oxide donor group, or pharmaceutically acceptable salts thereof, and novel composition comprising at least one diuretic compound comprising at least one heterocyclic nitric oxide donor group, and optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at least one diuretic compound of the invention comprising at least one heterocyclic nitric oxide donor group, and optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating conditions resulting from excessive water and/or electrolyte retention; (b) treating cardiovascular diseases; (c) treating renovascular diseases; (d) treating diabetes; (e) treating diseases resulting from oxidatives stress; (f) treating endothelial dysfunctions; (g) treating diseases caused by endothelial dysfunctions; (h) treating cirrhosis; (j) treating pre-eclampsia; (k) treating osteoporosis; (l) treating nephropathy; (m) treating peripheral vascular diseases; (n) treating portal hypertension; (o) treating central nervous system disorders; and (p) treating sexual dysfunctions. The heterocyclic nitric oxide donors are preferably furoxans, sydnonimines, oxatriazole-5-ones and/or oxatriazole-5-imines.
Owner:NICOX SA

Benzothiophene compound and application thereof in preventive and/or treatment medicine for breast cancer and osteoporosis

The invention relates to a novel benzothiophene derivative and application thereof in preventive and / or treatment medicine for breast cancer and osteoporosis. The benzothiophene derivative is an ideal selective estrogen receptor modulator, can be used for treating or preventing various indications related to estrogen functions, and is particularly applicable to treating post-menopause breast cancer and osteoporosis. The compound has the advantages that oxidative metabolism is lowered, effective bioavailability is higher, and accordingly, dosage of the compound is little, tolerance of the compound is fine, and side effects are low.
Owner:苏州波锐生物医药科技有限公司
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