406results about How to "Reduce development risk" patented technology

A method and system for applying addressing voltages to pixels of a display involves receiving input data. The input data includes an indication of an addressing voltage impulse to be applied to a pixel via an electrode. One or more voltage sources are selected, to provide the addressing voltage impulse. The one or more voltage sources each have a pre-selected voltage. The selected one or more voltage sources are electrically connected to an electrode to apply the addressing voltage impulse to the pixel.

Thrombopoietic compositions are provided comprising tyrosyl tRNA synthetase polypeptides, including truncations and / or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from increased thrombopoiesis, such as thrombocytopenia.

Peptides that are designed to inhibit the biological activity of the IL-1R type 1 receptor and inhibit IL-1R / IL-1RacP related cell signaling and biological activity are disclosed. Compositions comprising IL-1R antagonists of the present invention are useful in the treatment of IL-1 related diseases or conditions such as arthritis, rheumatoid arthritis, osteoarthritis, and inflammatory bowel disease as well as other chronic or acute inflammatory diseases. This invention also discloses an isolated compound having an IL-1R antagonist activity, said compound being selected from the group consisting of: a peptide comprising the amino acid sequence RYTPELX, wherein R, Y, T, P, E, L, refer to their corresponding amino acids, and X is selected from no amino acid and alanine (A); and a derivative of (a) wherein the derivative incorporates one, two or three amino acid modification selected from an amino acid addition, deletion or substitution in the RYTPEL portion of the peptide, and wherein said derivative maintains its antagonist IL-1R activity.

Composition enriched with natural phyto-estrogens or analogs thereof selected from Genistein, Daidzein, Formomometin, and Biochanin A. These may be used as food additives, tablets, or capsules for promoting health in cases of cancer, premenstrual syndrome, menopause, or hypercholestrolaemia.

The invention discloses a mobile terminal software testing system and software testing method. The method comprises the steps: (1) providing a testing platform, wherein the testing platform comprises a plurality of testing terminals and a testing server, the testing terminals are connected to mobile terminals to be tested, and the testing terminals are connected to the testing server; (2) receiving a test case input by a user through the mobile terminals, and sending the test case to the testing platform, wherein the test case is input by the user through a preset test case management module; (3) generating a test path and a test code through the testing platform according to the test case, and initiating an automatic test request to at least one testing terminal according to a user command; (4) analyzing a test code command through the testing terminals according to a configuration table, downloading and installing a corresponding automation code, running the code on a corresponding mobile terminal, and monitoring and reporting an operation state in real time.

The invention discloses a flexible switching system for a vehicle welding production line. The flexible switching system is used for solving the problems of low operating efficiency and poor universality in a current vehicle welding production line. The flexible switching system comprises a piece supplying mechanism, a transition track, a storage mechanism, a rotating platform, a trolley, a steering track switching mechanism and a lifting track switching mechanism, wherein the piece supplying mechanism and the rotating platform are arranged on two ends of the transition track, the storage mechanism is arranged on two sides of the transition track, the steering track switching mechanism is mounted in a joint position of the storage mechanism and the transition track, the lifting track switching mechanism is arranged on the transition track, and the trolley can move among the piece supplying mechanism, the storage mechanism and the rotating platform. According to the flexible switching system, an operating speed of a welding production line is improved, and synchronous operations of the piece supplying and the welding are realized. The flexible switching system is suitable for the mixing-line production of various vehicles, so that the cost on equipment development and operation is lowered, and the efficiency of welding production is improved.

Combination therapy comprising the administration of an 11β-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent useful for treating, preventing and reducing the risk of developing insulin resistance, dyslipidemia, obesity, hypertension and other related diseases and disorders.

The invention discloses a combined aircraft composed of a fixed wing and an electric multi-rotor wing. The combined aircraft comprises a group of electric multi-rotor wing power systems and a general controller; a fixed wing power system and the electric multi-rotor wing power systems are independent in structure; the general controller comprises a fixed wing control system and an electric multi-rotor wing control system for controlling the electric multi-rotor wing power systems to work; the general controller is further used for controlling the fixed wing control system and the electric multi-rotor wing control systems to work independently or work cooperatively; and a rotor wing rotary plane of the electric multi-rotor wing power system is parallel to a central axis of a machine body. The combined aircraft disclosed by the invention can freely convert between two flying modes, can vertically ascend and descend and fly as a helicopter and can also ascend and descend and fly as a fixed wing airplane; and the flying of the combined aircraft can be realized by using a mode of the mixing work of the two power systems in ascending, descending and flying processes.

This invention provides: 1) a method of treating androgen-deprivation induced osteoporosis and / or bone fractures and / or loss of Bone Mineral Density (BMD) in a male subject suffering from prostate cancer; 2) a method of preventing androgen-deprivation induced osteoporosis and / or bone fractures and / or loss of Bone Mineral Density (BMD) in a male subject suffering from prostate cancer; 3) a method of suppressing or inhibiting androgen-deprivation induced osteoporosis and / or bone fractures and / or loss of BMD in a male subject suffering from prostate cancer; and 4) a method of reducing the risk of developing androgen-deprivation induced osteoporosis and / or bone fractures and / or loss of BMD in a male subject suffering from prostate cancer, by administering to the subject a pharmaceutical composition comprising an anti-estrogen agent and / or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof as described herein.

The subject invention relates to methods for improving a subject's vasculature to normalize maternal hemodynamics, particularly in subjects attempting to conceive via assisted reproductive technologies, and comprises increasing relaxin levels in a subject or increasing any one or more of: relaxin synthesis, relaxin receptor synthesis, relaxin binding to the relaxin receptor, or relaxin receptor activity.

The invention relates to an automatic stop announcement method of a bus, pertaining to a bus information-releasing method. The method solves the problems of difficult data adjustment and low accuracy of stop announcement under a complicated situation, and comprises the following steps: a bus terminal receives and stores a data sequence of stop announcement in a running route, sent out by a control center through mobile communication. When the bus is in running, the bus terminal first combines current GPS location information with stop location information of auxiliary beacons to periodically find out the nearest stop as a current stop in the running route from the data sequence of the stop announcement. The running modes, namely, the uplink or the downlink, is determined when the bus runs into the current stop. And then the bus terminal adjusts the running mode according to the data sequence, controls the broadcasting and displays the information of the current stop; when the bus leaves the stop, the bus terminal, combining the running mode and in accordance with the data sequence, controls the broadcasting and displays leaving information consisting of the name of the next stop, and sets the next stop in the running route as the current stop.

The invention relates to an electromechanical coupling transmission device of a crawler. The device comprises an engine, a power coupling and gear shifting mechanism, two motors, a power control unit and an energy storage system, wherein the two motors are connected with sun gears of two planet rows of the power coupling and gear shifting mechanism respectively, a gear ring of the two planet rowsof the power coupling and gear shifting mechanism is shared, a clutch is arranged between the two sun gears and the shared gear ring, and the shared gear ring is provided with a brake and output through a planet carrier. The transmission device removes a steering gear set and a zero shaft of double-flow transmission of the crawler, and has flexible allocation, capability of making full use of space and compact structure. Because of the power coupling and gear shifting mechanism, the requirement for the motors is reduced, and the research and manufacture risks of the motors are reduced.

Compositions and methods for improving the nutritional and physiological status of a woman and her child during all stages of pregnancy are provided herein. This includes pre-conceptional women, pregnant women, and post-natal women (both lactating and non-lactating mothers). The compositions are particularly useful for the neurological, visual, and cognitive development of an embryo, fetus, or infant and the nutritional and physiological well-being of the mother, fetus, and infant. The compositions contain one or more folates, such as a reduced folate and / or folic acid, and one or more essential fatty acids (EFA), such as an omega-3 and / or omega-6 fatty acid. The addition of the essential fatty acid improves upon the folate containing nutritional preparations described in the prior art. The one or more folates and essential fatty acid may be administered together or in separate dosage units. The one or more folates may be selected from folic acid / folate, one or more reduced folates, or a combination of folic acid / folate and one or more reduced folates. The reduced folate is preferably 5-methyltetrahydrofolate, and most preferably 5-methyl-(6S)-tetrahydrofolic acid. The essential fatty acid is preferably an omega-3 fatty acid, and is preferably docosahexenoic acid (DHA) derived from a vegetarian or non-fish source. The compositions may optionally contain other vitamins, minerals, and ingredients, such as, emollient laxatives—all defined herein as “optional or other ingredients”.

The invention provides an embedded satellite configuration. The embedded satellite configuration comprises a platform cabin, a loading cabin, a docking locking-unlocking mechanism, a non-contact magnetic suspension direct force control mechanism and a solar cell array. The platform cabin is in a hollow annular structure; the loading cabin is arranged in the platform cabin; the docking locking-unlocking mechanism and the non-contact magnetic suspension direct force control mechanism are arranged between the platform cabin and the loading cabin respectively; the solar cell array is arranged on the side of the platform cabin. Ultrahigh-precision ultrahigh-stability control requirements of satellites are met, quality characteristics and agile mobility performances of the satellites are improved, a loading space environment is improved, and influences of platform disturbance and thermal cycling on satellite loading are reduced. According to a design conception of non-contact split design and centralized control, the embedded satellite configuration has advantages of structural configuration compactness, high control precision, high environmental adaptability, low development risk, short cycle and simplicity and feasibility in integration and final assembly.

The invention relates to a hybrid assembly test bed system of a passenger vehicle and belongs to the technical field of hybrid assembly test of passenger vehicles. A dynamometer control system is respectively connected with a dynamometer 1 and a dynamometer 2; the dynamometer control system is connected with a simulation development platform through Ethernet; a control unit is connected with the simulation development platform; the network interface of the control unit is connected with a battery simulator through a CAN (controller area network) bus; the hardware interface of the control unit is connected with an accelerator pedal, a brake pedal and a shift knob, and the control unit is internally provided with a virtual model; and the simulation development platform comprises a vehicle and assembly development simulation system and a remote controller. According to the invention, a systemic solution and a verification method are provided for hybrid car development, the entire car development cycle is shortened, and the entire car development cost is lowered, thus the system is innovation in the field of new energy source test equipment.

The invention involves administration of an immunostimulatory nucleic acid in combination with a cancer medicament for the treatment or prevention of cancer in subjects. The combination of drugs are administered in synergistic amounts or in various dosages or at various time schedules. The invention also relates to kits and compositions concerning the combination of drugs.

A method is provided that includes identifying that a subject is at risk of suffering from vascular dementia (VaD). Responsively to the identifying, a risk of development of the VaD is reduced by applying electrical stimulation to a site of the subject selected from the group consisting of: a sphenopalatine ganglion (SPG), a greater palatine nerve, a lesser palatine nerve, a sphenopalatine nerve, a communicating branch between a maxillary nerve and an SPG, an otic ganglion, an afferent fiber going into the otic ganglion, an efferent fiber going out of the otic ganglion, an infraorbital nerve, a vidian nerve, a greater superficial petrosal nerve, and a lesser deep petrosal nerve; and configuring the stimulation to induce at least one neuroprotective occurrence selected from the group consisting of: an increase in cerebral blood flow of the subject, and a release of one or more neuroprotective substances. Other embodiments are also described.

The invention provides an automobile suspension key structure element optimization design method, which comprises the following steps of: building a suspension system kinetic model according to a pre-determined suspension system development scheme, and obtaining an equivalent load of a suspension structure element connecting point under a typical work condition; building a suspension system mechanism kinetic model, and determining an initial design domain of a development structure element; building a limited element analysis model of the initial design domain of the development structure element; obtaining the material distribution of the development structure element and determining a basic topological configuration of the development structure element; obtaining a conceptual design model of the development structure element; and obtaining each parameter optimum scheme of the conceptual design model of the development structure element and an optimization design model. When the embodiment of the invention is implemented, the development period of the suspension key structure element can be effectively shortened; and the reference can be provided for the optimization design of other system parts of an automobile.

The present invention, among other things, provides technologies for detecting and / or quantifying nucleic acids in cells, tissues, organs or organisms. Through sequential barcoding, the present invention provides methods for high-throughput profiling of a large number of targets, such as transcripts and / or DNA loci. In some embodiments, nucleic acid probes include a signal moiety connected with a binding sequence via a cleavable linker.

A method is provided that includes identifying that a subject is at risk of suffering from vascular dementia (VaD). Responsively to the identifying, a risk of development of the VaD is reduced by applying electrical stimulation to a site of the subject selected from the group consisting of: a sphenopalatine ganglion (SPG), a greater palatine nerve, a lesser palatine nerve, a sphenopalatine nerve, a communicating branch between a maxillary nerve and an SPG, an otic ganglion, an afferent fiber going into the otic ganglion, an efferent fiber going out of the otic ganglion, an infraorbital nerve, a vidian nerve, a greater superficial petrosal nerve, and a lesser deep petrosal nerve; and configuring the stimulation to induce at least one neuroprotective occurrence selected from the group consisting of: an increase in cerebral blood flow of the subject, and a release of one or more neuroprotective substances. Other embodiments are also described.

The invention relates to a humanized gene genetically modified non-human animal, particularly a genetically modified rodent, especially a genetically modified mouse, and in particular relates to a construction method of a humanized PD-L1 gene animal model and application of the model in the biomedicine field.

A device for monitoring the activity of a user to prevent deep vein thrombosis when travelling on transportation vehicles. The device comprises a carrier (20) for positioning on or adjacent a user, a motion sensor (10) mounted on the carrier (20) and adapted to detect the user performing a predefined motion, processor adapted to filter the motion detected to remove background motion not attributable to the desired exercise and to reset a timer (12) when the predefined motion is detected. An alarm (14) is operated by the processor should the time period elapse without the exercise pattern being detected. The components are all contained in the carrier (20) which is preferably a small container that can be attached to a user's trousers or around the limb of a wearer. Failure to undertake the required motion will cause the alarm (14) to be activated, thus notifying the wearer of the omission.

The present invention provides compositions and methods based on genetic polymorphisms that are associated with cardiovascular diseases, particularly coronary heart disease (especially myocardial infarction) or hypertension. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.

The present invention relates to antibodies capable of binding to the coagulation Factor XI and / or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.

The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of AMD.

The invention discloses a fault simulation method and system for a flight control system, and belongs to the field of flight control systems. The system mainly comprises a flight control system testing control platform, a simulation management system, and a bus signal simulation system. The flight control system testing control platform collects the output of the flight control system, and correspondingly transmits the output to the simulation management system. The simulation management system carries out dynamics mathematic model solving and transmits the solving results to the bus signal simulation system. The bus signal simulation system converts the solving results into various types of bus simulation signals, needed by the flight control system, through a bus signal conversion device, and transmits the signals to the flight control system. The flight control system makes the corresponding posture response according to various collected bus simulation signals. During fault simulation testing, the flight control system testing control platform sets various faults of the flight control system in real time through corresponding fault setting means, thereby achieving the testing of the response capability of the flight control system to various faults.

The invention discloses a data item calibration method based on a JSP page, belonging to a data item calibration method. A javaScript script file is written in JSP and is calibrated. The invention comprises (1) JSP, data item description, other page display contents, write-in data item and page submitting triggering; (2) a calibrating rule controller, an data item and route configuration of the calibrating rule, wherein the calibrating rule controller serves as a configuration file to store the corresponding relation of the data item and calibrating rule identification, is in an XML form and can realize rule route by simple configuration; and (3) a calibration database, comprising a public function, an arithmometer and a user-defined function library. Compared with the prior art, the data item calibration method based on a JSP page of the invention is simple and flexible, has low cost, can improve system development efficiency and can lower the technical requirements of on-site implementing maintenance personnel.