46results about How to "Reduced incidence and severity" patented technology

The invention provides methods of preventing and / or treating infection by a respiratory virus such as respiratory syncytial virus (RSV) and SARS-associated coronavirus, particularly reducing infection and / or one or more symptoms of respiratory virus infection. A polynucleotide comprising an immunostimulatory sequence (an "ISS") is administered to an individual which is at risk of being exposed to a respiratory virus, has been exposed to a respiratory virus or is infected with a respiratory virus. The ISS is administered without any antigens of the respiratory virus. Administration of the ISS results in reduced incidence and / or severity of one or more symptoms of respiratory virus infection.

The present invention relates to detection of the presence or absence of cerebrospinal fluid (CSF) in a sample, in particular to the analysis of the CSF protein lipocalin-type prostaglandin D2 synthase (PGDS). The present invention provides assays for the analysis of PGDS indicating the presence or absence of CSF in a sample.

A controlled-release dosage form of azithromycin having an improved side effect profile; a process for preparing the dosage form; and a method of treating a microbial infection, comprising administering azithromycin in such a controlled-release dosage form to a mammal, including a human patient, in need of such treatment.

The present invention relates to compositions to be administered to infants delivered via caesarean section and in particular to a product comprising inactivated cells and / or bacterial cell fragments of Gram-negative bacteria and of optionally inactivated Gram-positive bacteria. Thereby it is possible to stimulate a fast colonisation of the intestinal microbiota of said infants.

Techniques and wearable appliances for monitoring bruxism, and / or for alleviating bruxism or sleep apnea related to bruxism are provided. In certain example embodiments, there is provided a custom teeth guard configured to be attached to at least some teeth in one of the upper or lower jaws, having at least two different non-zero amounts of padding arranged at positions located between teeth in the upper jaw and teeth in the lower jaw in accordance with predetermined strength of grinding of teeth at the positions. The custom teeth guard may be useful in helping to preempt apneic events and / or the like, e.g., by reducing the incidence and / or severity of teeth grinding.

The present invention relates to methods of producing a food or malt-base beverage suitable for consumption by a subject with Coeliac's disease. In particular, the present invention relates to methods of producing a food or malt-based beverage with low levels of hordeins. Also provided are barley plants which produce grain that can be used in the methods of the invention.

The invention relates to a method for increasing the toughness and / or stiffness of bone and / or reducing the likelihood and / or severity of bone fracture by administering a parathyroid hormone. The method can be employed to increase toughness or stiffness of bone at a site of a potential or actual trauma, such as the hip or spine of a person at risk of or suffering from osteoporosis. The method of the invention can reduce the incidence of vertebral fracture, reduce the incidence of multiple vertebral fractures, reduce the severity of vertebral fracture, and / or reduce the incidence of non-vertebral fracture.

Disclosed are methods for treating various cancers. Methods encompass the administration of a first drug such as AP23573, temsirolimus or everolimus in combination with a second drug selected from Remicade, Humira, Enbrel, Raptiva, Abatacept, Actermra, Cimzia or anakinra.The methods are aimed at providing a desirable therapeutic window while maintaining prior, if not higher, dose levels of the first drug.

Provided herein are methods and compositions for modulating signal transduction pathways by regulating the expression and / or activity of Midline-1, enabling the inhibition of airways inflammation, the inhibition of airways hyperresponsiveness, the inhibition of rhinovirus-associated inflammation, and reductions in cytokine and chemokine release. Methods and compositions disclosed herein facilitate the treatment and prevention of conditions associated with airway inflammation, airway tissue remodelling and rhinovirus-associated inflammation and symptoms, manifestations and exacerbations thereof, in particular of allergic diseases such as allergic airways diseases including asthma.

The invention provides a method of ameliorating the symptoms of catatonia in a patient who is in need of treatment for catatonia. The method comprises administration of a therapeutically effective amount of a glucocorticoid receptor antagonist to the patient.

A method of reducing rotor bow in a high pressure rotor of a gas turbine engine that has in axial flow a low pressure rotor and a high pressure rotor. The method involves storing bleed air from the gas turbine engine when the engine is running to provide stored pneumatic energy; and using that stored pneumatic energy after the engine has been shut-down to rotate the high pressure rotor at a speed and for a duration that reduces rotor bow. A gas turbine engine wherein rotor bow in the high pressure rotor after engine shut-down has been reduced by carrying out the aforesaid method is also disclosed.

A method for treating an ATP analog-induced side effect in a subject comprises administering an effective amount of an adenosine receptor antagonist to the subject. A method for treating cancer in a subject comprises administering a nucleobase and / or nucleoside prior to administering an ATP analog.

A hard or chewable candy, beverage, effervescent powder or tablet, or dietary supplement composition serves as a relaxant and mind energizer. The combination affords the benefit of reduction in the incidence or severity of stomach upset and / or hangover sometimes associated with the primary ingredient, kavalactones. The composition comprises kava root extract and at least one additional component of lemon balm or chamomile extract.

The invention relates to a method for increasing the toughness and / or stiffness of bone and / or reducing the likelihood and / or severity of bone fracture by administering a parathyroid hormone. The method can be employed to increase toughness or stiffness of bone at a site of a potential or actual trauma, such as the hip or spine of a person at risk of or suffering from osteoporosis. The method of the invention can reduce the incidence of vertebral fracure, reduce the incidence of multiple vertebral fractures, reduce the severity of vertebral fracture, and / or reduce the incidence of non-vertebral fracture.

Non-aqueous liquid compositions comprising nimodipine having improved stability over aqueous compositions comprising nimodipine are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the non-aqueous liquid compositions of the present invention are also detailed herein.

The present invention relates to controlled release pharmaceutical formulations of active principle(s) like tetracycline-class antibiotics for providing increased residence time in the gastrointestinal tract and the process of preparing them.

The described invention provides delivery systems, compositions and methods for reducing incidence or severity of atrial fibrillation in a subject at risk thereof, the method comprising providing a delivery system in a form that is malleable comprising a particulate formulation containing a plurality of particles comprising a therapeutic amount of an anti-arrhythmic agent; and a pharmaceutically acceptable carrier, wherein the therapeutic amount of the therapeutic agent is effective to reduce the incidence or severity of atrial fibrillation.

The disclosure features human milk compositions as well as methods of making human milk compositions and using human milk compositions. In particular, the disclosure features a method of using milk compositions to provide nutrition for subjects who are undergoing or have undergone bone marrow transplants.

The invention relates to a method for increasing the toughness and / or stiffness of bone and / or reducing the likelihood and / or severity of bone fracture by administering a parathyroid hormone. The method can be employed to increase toughness or stiffness of bone at a site of a potential or actual trauma, such as the hip or spine of a person at risk of or suffering from osteoporosis. The method of the invention can reduce the incidence of vertebral fractures, reduce the incidence of multiple vertebral fractures, reduce the severity of vertebral fracture, and / or reduce the incidence of non-vertebral fracture.

The invention provides a method for improving airway conductance in a subject in need thereof, the method comprising administering to the subject an effective amount of one or more of tumstatin; a derivative, variant or homologue thereof, a polynucleotide encoding tumstatin or a derivative, variant or homologue thereof; or an agent capable of increasing the expression or production of tumstatin.

Provided are methods of inducing satiety in an individual using gastric raft compositions and compositions suitable for such methods. The gastric raft compositions may comprise processed starches such as dextrins. Also described are methods of treating diseases characterised by hypoglycaemia, such as glycogen storage disease (GSD), and diabetes.

Hydroxylated derivatives of vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol) are effective for preventing or treating mastitis in animals. The hydroxylated derivatives of vitamins D3 or D2 are administered to the mammary gland of a female animal in an amount effective to inhibit or significantly reduce the growth of bacteria in the animal's mammary gland.

The invention provides recombinant Streptococcus mutans strains that can be used to improve oral health. An embodiment of the invention provides a method of reducing the incidence or severity of dental caries in a dental caries-susceptible host comprising administering orally to the host an isolated recombinant S. mutans strain of the invention in an amount effective for replacement of dental caries-causing S. mutans host strains in the oral cavity of the host. The isolated recombinant S. mutans strain 10 can be contained in a mouthwash, toothpaste, chewing gum, floss, chewable tablet, food, or beverage.

The present disclosure provides methods for treating traumatic brain injury and other neurological disorders in a subject in need thereof, comprising administering to the subject an effective amount of a composition comprising ghrelin or a ghrelin variant. This invention provides for methods for treating a severe or moderate traumatic brain injury in a patient wherein said method comprises administering to the subject suffering from said severe or moderate traumatic brain injury a therapeutic effective amount of ghrelin or a ghrelin variant or a composition comprising ghrelin or a ghrelin variant so as to treat said severe or moderate traumatic brain injury.

A system for treating and preventing multiple forms of acne includes applying a solution to the skin to assist maintaining the skin's natural acidic mantle of 4.0 to 6.5, preserve moisture transport properties, and maintain specialized lipid content, allowing the skin to function normally, and assisting the skin to heal wounds caused by acne and associated bacterial infections. The method steps include one or more of the following: applying the formulation with surfactants incorporated therein to the skin as a cleanser, rinsing with water; applying the solution, with or without surfactants, and allowing the solution to air dry; repeating the applications and allowing them to air dry throughout the day; and repeating the cleansing and rinsing steps and applying the solution and allowing to air dry before retiring. One or more of the method steps may be repeated on a continual basis, typically daily, for an extended period of time.

The invention belongs to the technical field of bleeding disease control, and discloses a method for controlling a bleeding disease of lemon trees. The method includes: applying a fruit picking fertilizer to a lemon orchard during September-October every year, controlling the use amount of a nitrogenous fertilizer, adding a potassium fertilizer and a boric fertilizer, and suitably supplying a calcium fertilizer and a zinc fertilizer; performing winter whitewashing on the lemon planting orchard during October-December in autumn and winter every year, and importantly whitewashing trunks of lemon trees and bleeding disease parts of the trunks; checking the bleeding disease morbidity of the lemon trees during a peak stage of the bleeding disease in July-August in the next year, and whitewashing the trunks and the bleeding disease parts of the trunks again; spraying the lemon trees with a chemical fertilizer in a root outside manner so as to control the bleeding disease, controlling the use amount of a nitrogenous fertilizer, adding a potassium fertilizer, and suitably supplying a boric fertilizer; and suitably supplying a boric fertilizer while controlling the branch diseases of the lemon trees from a fruit expansion early stage to a fruit expansion middle stage of the lemon trees. The method can mainly control the bleeding disease, can lower the morbidity and the serious degree of the bleeding disease, and can increase the economic benefits of the lemon trees.