Blood lipid level and coronary heart disease related rs7901016 detecting system and related application

A level and site technology, applied in the rs7901016 detection system related to blood lipid level and coronary heart disease and related application fields, can solve the problem of lack of Asian population research data and other problems

Active Publication Date: 2018-02-02
FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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Problems solved by technology

However, almost all of these loci were originally identified in populations of European ancestry, and data from studies in Asian populations, especially Chinese populations, are lacking

Method used

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  • Blood lipid level and coronary heart disease related rs7901016 detecting system and related application
  • Blood lipid level and coronary heart disease related rs7901016 detecting system and related application
  • Blood lipid level and coronary heart disease related rs7901016 detecting system and related application

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Embodiment 1

[0024] The invention is divided into two stages (preliminary screening stage and verification stage) to respectively detect and analyze the genetic variation related to TC, LDL-C, HDL-C and TG.

[0025] The study population was East Asian population, including 44,985 subjects in the first phase and 13,408 subjects in the validation phase. Each study was approved by the ethics committee of its research institution and the local investigating institution. All participants signed informed consent in writing.

[0026]In the first stage, a meta-analysis of exome association studies was conducted on 44,985 survey subjects in the East Asian population. 44,985 subjects, from China Eye Study (CHES), China Health and Nutrition Survey (CHNS), Fangchenggang Male Health Examination Survey (FAMHES), Guizhou Bijie Type 2 Diabetes Study (GBTDS), Hong Kong University Special Research Program (HKU-TRS) ), Hubei Coronary Heart Disease Study (HuCAD) and Chinese Aging Population Nutrition and He...

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Abstract

The invention provides a blood lipid level and coronary heart disease related rs7901016 detecting system and related application, particularly determines relevance between single nucleotide polymorphism rs7901016 and blood lipid level, provides application of reagent materials and / or instruments for detecting polymorphism of a rs7901016 locus in a sample of a to-be-tested individual to preparationof a detecting system for assessment of blood lipid level, dyslipidemia and / or coronary heart disease risks, and further provides the detecting system for assessment of the blood lipid level, dyslipidemia and / or coronary heart disease risks. The detecting system comprises the reagent materials and / or instruments for detecting polymorphism of the rs7901016 locus in the sample of the to-be-tested individual, wherein rs7901016 is remarkably related to LDL-C level, and rs7901016 locus T allele carriers are higher in LDL-C level and / or coronary heart disease risks than non-carriers.

Description

technical field [0001] The present invention relates to a single nucleotide polymorphism rs7901016 detection system related to blood lipid levels and coronary heart disease and related applications, in particular, the present invention relates to a reagent for detecting the polymorphism of the CD16 gene rs7901016 site in a sample from an individual to be tested Application of materials and / or instruments and equipment in the preparation of a detection system for evaluating blood lipid levels, abnormal blood lipids and / or risk of coronary heart disease, and also relates to a detection system for evaluating blood lipid levels, abnormal blood lipids and / or risk of coronary heart disease . Background technique [0002] A large number of research data show that dyslipidemia is an independent risk factor for coronary heart disease, myocardial infarction, sudden cardiac death and ischemic stroke. It causes hidden, gradual, progressive, systemic and organic damage to the body by ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/156C12Q2600/172
Inventor 鲁向锋顾东风黄建凤陈恕凤李建新
Owner FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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