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Blood lipid-lowing active fractions of forsythia suspensa and preparation method and use of same

An effective part, a technology for lowering blood lipids, which is applied in the application field of the preparation of antioxidant drugs, and achieves the effects of good application prospects, good antioxidant activity, and lowering blood lipid levels.

Inactive Publication Date: 2009-09-23
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, the application and development of forsythia leaves are mainly concentrated on the highly polar water part, and its main active ingredient is forsythin or forsythiaside, while the research on fat-soluble parts, especially the research on the active ingredients Not yet reported

Method used

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  • Blood lipid-lowing active fractions of forsythia suspensa and preparation method and use of same
  • Blood lipid-lowing active fractions of forsythia suspensa and preparation method and use of same
  • Blood lipid-lowing active fractions of forsythia suspensa and preparation method and use of same

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] The effective part of this embodiment - the preparation method of the ethyl acetate part is as follows: take the dried forsythia leaf, cold-soak 3 times with acetone and water at a volume ratio of 7:3, each time for 7 days, filter, and combine the filtrates to reduce pressure The solvent is recovered to obtain a concentrate. The concentrated extract was dispersed in water and extracted three times with ethyl acetate to obtain the ethyl acetate fraction.

Embodiment 2

[0067] Take the ethyl acetate part prepared in Example 1, and perform silica gel atmospheric pressure column (200-300 mesh) chromatography, petroleum ether-ethyl acetate 15:1 elution, and the eluate is subjected to acetone gel column chromatography, chloroform :cyclohexane:methanol=9:9:2 gel column chromatography to obtain compound forsythiatin.

[0068] Structure Identification:

[0069] 【Properties】Colorless needle crystal (methanol recrystallization)

[0070] 【Identification】Molecular formula: C 21 h 24 o 6 , molecular weight: 372

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Abstract

The invention relates to blood lipid-lowering active fractions of forsythia suspensa and a preparation method and use of the same. The active fractions are ethyl acetate fractions obtained by concentrating an extract which is extracted from forsythia suspensa leaves by acetone and water. The compound of phillygenin prepared by the invention and the active fractions, namely the ethyl acetate fractions, at which the phillygenin is positioned have good antioxidant activity in vitro. In-vivo experiments show that the ethyl acetate fractions and the phillygenin can lower total cholesterols and low-density lipoprotein cholesterin in the blood serum of a mouse with hyperlipidemia and can lower blood lipid level by an oxidative approach (raising superoxide dismutase SOD and lowering malonydialdehyde MDA). In addition, the ethyl acetate fractions have a better effect of reducing the total cholesterols in the blood serum of the mouse than the phillygenin and cassia seed blood lipid-lowering tablets. The ethyl acetate fractions of the forsythia suspensa leaves can be further developed to play a role in the multi- target co-prevention and treatment of hyperlipidemia and other diseases and have a good application prospect.

Description

technical field [0001] The present invention relates to extracting and preparing an effective part for lowering blood fat from the fat-soluble part of forsythia leaf, and also relates to a preparation method of the effective part, and an application of the effective part in preparing antioxidant drugs. Background technique [0002] Forsythia suspense (thumb.) Vahl is a plant of the genus Forsythia in Oleaceae, slightly cold in nature, bitter in taste, and returns to the lung, heart, and small intestine channels. It has the effects of clearing away heat and detoxification, reducing swelling and dissipating stagnation, and is mainly used to treat carbuncle, scrofula, warm heat, erysipelas, and urinary stranguria. [0003] Hyperlipaemia (Hyperlipaemia, HLP) mainly refers to serum total cholesterol (TC) or triglyceride (TG) levels are too high and (or) serum high-density lipoprotein-cholesterol (HDL-C) levels are too low. Hyperlipidemia is a common and frequently-occurring dise...

Claims

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Application Information

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IPC IPC(8): A61K36/634A61P3/06A61P39/06C07D493/04A61K127/00
Inventor 康文艺许启泰王金梅李晓梅李彩芳宋艳丽
Owner HENAN UNIVERSITY
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