174results about How to "Lower fasting blood sugar" patented technology

The invention discloses a composition and an application thereof in regulating intestinal flora of animals. The composition contains aloe, probiotics and prebiotics, wherein the mass ratio of the aloe to the probiotics to the prebiotics is (6 to 3 to 1)-(6 to 1 to 3). The inventor discovers that the composition disclosed by the invention can effectively promote the proliferation of useful bacteria such as bifidobacterium and lactobacilli in animal intestines, so as to effectively regulate the intestinal flora of animals; therefore, the composition can be used for preventing or treating diabetes on the basis of the effect of the intestinal flora.

The invention relates to a composite composition with metformin hydrochloride and repaglinide as active ingredients, a preparation method thereof and application thereof and belongs to the technical field of medicaments. The composite composition is a medicinal composition which is mixed by using the metformin hydrochloride and repaglinide as the active ingredients and by using a carrier and can be prepared into sustained-release tablets, sustained-release granules, sustained-release capsules, common troches and capsules, granules, dispersible tablets, chewable tablets, orally disintegrating tablets, buccal tablets, liquid capsules, soft capsules, drop pills and other oral preparations. The composite composition is used for treating patients with I-type diabetes or II-type diabetes (non-insulin-dependent diabetes) and has synergistic effect on controlling blood sugar.

The invention discloses an edible composition, comprising a probiotic culture. The probiotic culture is obtained by cultivating probiotics by using a culture medium. The edible composition disclosed by the invention has the functions of adjusting intestinal flora, regulating blood sugar level, reducing blood fat and improving the immunity.

The present invention relates to a fermented coconut milk drink and a preparation method thereof, the fermented coconut milk drink is prepared from coconut milk, syrup or a sugar substitute, and pure water as raw materials for fermentation by selected plant lactobacillus, the fermented coconut milk drink is prepared by the method is unique in flavor, nutrient-rich, and smooth and fresh in taste, the short chain fatty acid level of the fermented coconut milk drink is significantly improved after fermentation by the plant lactobacillus, and the fermented coconut milk drink can significantly reduce total cholesterol (TC) and triglyceride (TG) content in fasting blood-glucose and blood fat of hyperlipemia rats, and has significant health benefits.

The invention relates to a propolis soft capsule. The propolis soft capsule comprises a rubber sheet and a capsule content, wherein the capsule content comprises the following components in percent by weight: 20%-60% of propolis supercritical CO2 extract, 30%-70% of wheat-germ oil and 1%-10% of vitamin E; components of the rubber sheet are gelatin, glycerol and purified water in a weight ratio of 100:42:100. The propolis soft capsule is integrated with improving effect of propolis on diabetes mellitus and preventing effect of vitamin E on chronic complication of the diabetes mellitus; moreover, the components are good in synergistic effect. The invention also provides a preparation method of the propolis soft capsule.

The invention relates to a self-screened Lactobacillus acidophilus SJLH001 (La SJLH001 for short) with probiotic function of regulating blood sugar and cholesterol level and application thereof in probiotic food. The strain has good tolerance to gastrointestinal environment, and has antioxidant, hydrophobic, ultrasonic resistance, reducing power and other in vitro benefits. In vitro and in vivo functional tests showed that La-SJLH001 has significant amylase inhibitory activity and alpha-Glucose glycerase inhibitory activity, and can significantly reduce fasting blood glucose, postprandial blood glucose level, enhance the tolerance of glucose, alleviate the pancreatic islet enlargement, reduce serum cholesterol level, enhance intestinal mucosal protection and other functions. La- SJLH001 has significant hypoglycemic and cholesterol-lowering activities, which makes it widely used in various forms of probiotic foods (such as probiotic tablet candy, probiotic solid drinks, etc.).

The invention relates to the field of health-care products, and particularly relates to a composite with a function of assisting in decreasing blood glucoses and products thereof. The composite is composed of chitosan oligosaccharide and L-arabinose. The composite disclosed by the invention integrates chitosan oligosaccharide and L-arabinose to be taken, due to the taking of the chitosan oligosaccharide, the effects of promoting the insulin secretion of bodies, increasing the sensitivity of insulin receptors and enhancing the utilization of blood glucose are achieved, and due to the taking of the L-arabinose, the effects of restraining the sugar absorption of the human body and reducing the generation and absorbing amount of glucose are achieved, so that controlling the blood glucose can be controlled within a normal range of the human body through a two-way adjustment function.

The invention discloses a composition of probiotic-fermented corn stigma as well as a preparation method of the composition. The composition is prepared by the following steps: drying and crushing the corn stigma, soaking the corn stigma, conducting probiotic fermentation, and adding a sweetening agent. The corn stigma, through the probiotic fermentation, is relatively high in content of corn stigma total saponins and relatively low in molecular weight of corn stigma polysaccharides; and the fermented corn stigma can take such effects on lowering blood glucose, reducing blood fat, relieving swelling and inducing diuresis, clearing away heat and toxic materials, calming liver and benefiting gallbladders, improving constipation and the like. The composition of the probiotic-fermented corn stigma disclosed by the invention has easily acceptable taste and the composition is non-irritant to gastrointestinal tracts; and meanwhile, the composition, which contains probiotics and metabolites thereof, is capable of conditioning the environment of the gastrointestinal tracts and enhancing drug absorption.

The invention provides a composition for preparation of foods or drugs for preventing, improving or treating type II diabetes. The composition comprises sea cucumber total saponins or a sea cucumber saponin. Results of animal experiments show that the sea cucumber total saponins or the sea cucumber saponin can reduce obviously a fasting blood glucose value and improve significantly an insulin resistance thus has obvious effects of improving, preventing or treating II type diabetes and can be utilized alone and adopted as a component or an auxiliary material to be prepared into foods or drugs.The preparation method of the sea cucumber saponin-containing composition has the advantages of low cost, simple processes and less pollution of organic solvents on environment. Results of an animal experiment show that the sea cucumber saponin-containing composition have good effects of improving, preventing or treating II type diabetes and can be utilized for development of foods or drugs for improving, preventing or treating II type diabetes.

The invention discloses Fu tea and a preparation method and use thereof. The method comprises the following steps: providing a eurotium cristatum spore suspension; and inoculating the eurotium cristatum spore suspension in raw dark green tea and fermenting to obtain the Fu tea. By virtue of the method, the Fu tea with flourishing golden flowers can be effectively prepared, and the method is simple and is easy to operate and control.

The invention provides poria cocos cellulose fiber. The poria cocos cellulose fiber is prepared by mixing a cellulose spinning stock solution with poria cocos extract, wherein the mass percent of poria cocos extract in the poria cocos cellulose fiber is 8-15%. The invention further provides a preparation method of the poria cocos cellulose fiber. The content of poria cocos extract is 8-15%, the dry fracture strength is 1.8-2.5 cN / dtex, the wet fracture strength is 1.36-1.56 cN / dtex, the dry fracture elongation rate is 18.5-22.8%, the residual sulfur content is as low as 4.8-6.2 mg / 100g, the ultralong fiber rate is smaller than or equal to 1.0%, and the dry fracture strength coefficient of variation (CV) is smaller than or equal to 12%; the dust mite phobotaxis is good, the phobotaxis rate reaches 93-99%, the antibacterial effect is good, and the poria cocos release period is long.

The invention relates to application of total saponins in unripe siraitia grosvenorii fruit extract in preparation of an assistant hypoglycemic drug. Extract containing the total saponins with the content by weight of 60%-90% is extracted from unripe siraitia grosvenorii fruit with the growing period of 30 days-80 days, one of the effective ingredients mogroside II and mogroside III in the total saponins or a mixture of the effective ingredients mogroside II and mogroside III in the total saponins inhibits the activity of alpha-glucosidase in vitro and in vivo, the fasting blood-glucose level and the postprandial blood glucose level of a type-II diabetic mouse are lowered, and the activity of the insulin resistance index is reduced; in addition, new application of the total saponins in preparation of food or the drug for assisting in treating insulin resistance and type-II diabetes mellitus is achieved.

The invention belongs to the field of medicine and foods and relates to novel application of luffa seeds. The invention provides novel application of the luffa seeds to preparation of a medicament for treating and preventing diabetes mellitus and complications thereof. A blood sugar regulation medicinal composition or preparation can be prepared from the luffa seeds and one or more vectors or excipients which are acceptable on medicaments. Clinical experiments prove that the luffa seeds or luffa seed capsules can be used in combination with other blood sugar regulation medicaments and the effect of combining the luffa seeds or the luffa seed capsules and other blood sugar regulation medicaments is more obvious than that of separately using the blood sugar regulation medicaments; separate use of the luffa seeds or the luffa seed capsules can also obviously reduce blood sugar of a patient and the medicinal effect of the luffa seeds or the luffa seed capsules is more obvious that that of a common chemical synthetic medicament for preventing diabetes mellitus; administration of the luffa seeds or the luffa seed capsules can also prevent a sugar tolerance patient and a potential diabetic patient (who is fat, has strong genetic background and has irregular living habits) from being converted into a diabetic patient; and the luffa seeds or the luffa seed capsules also has a good treating effect on complications (foot diseases in diabetes) of diabetes mellitus.

The invention discloses a bacterial strain as well as a composition and application, and relates to the technical field of strain separation and application. The Cristinia sp. provided by the invention can be applied to treatment or prevention of liver function impairment and liver function impairment related diseases, alimentary canal mucosal injury and alimentary canal mucosal injury related diseases, diabetes, obesity and obesity related diseases. The inventor verifies that the Cristinia sp. provided by the invention has no toxic or side effect on the kidney and can reduce the weight of the liver; the initial steatohepatitis focus can be treated; fat accumulation of liver cells can be slowed down; AST and ALT in serum can be reduced; and abdominal white fat inflammatory lesion can be reduced. The Cristinia sp. can also repair the digestive tract mucosa, recover the barrier function of the mucosa, and prevent and treat intestinal leakage, peptic ulcer and other diseases caused by barrier function impairment. The Cristinia sp. also has the effects of reducing fasting blood-glucose of a body, regulating insulin level and reducing body fat of mammals, and has the effects of preventing and treating diabetes and improving the metabolic function of obese patients.

The invention discloses rubus hirsutus anthocyanin and application thereof. The rubus hirsutus anthocyanin mainly comprises cyanidin-3-O-glucoside, pelargonine 3-O-glucoside and pelargonine 3-O-rutinoside, wherein the pelargonine 3-O-glucoside is main anthocyanin. An animal experiment proves that the rubus hirsutus anthocyanin can significantly reduce fasting blood glucose of db / db diabetic mice and shows excellent hypoglycemic activity in vivo. An in-vitro experiment proves that the rubus hirsutus anthocyanin can play a hypoglycemic role by inhibiting the alpha-glucosidase activity and promoting the glucose consumption of cells. Therefore, the rubus hirsutus anthocyanin can be taken as hypoglycemic functional food or a hypoglycemic drug for the prevention and the treatment of glycometabolism disorder-related diseases. The invention provides a new idea for comprehensive development and utilization of rubus hirsutus resources in China.

The invention discloses a traditional Chinese medicine for treating diabetes and belongs to the field of traditional Chinese medicine compositions. The traditional Chinese medicine comprises the following active ingredients in parts by weight: 11-15 parts of kudzuvine root, 16-24 parts of rehmannia root, 20-30 parts of astragalus, 14-27 parts of poria cocos, 22-33 parts of chinese magnoliavine fruit, 21-40 parts of polygonum cuspidatum, 23-36 parts of Chinese wolfberry root bark, 17-32 parts of dark plum fruit, 16-25 parts of trichosanthes root, 14-25 parts of cornus pulp and 15-19 parts of Chinese yam. The traditional Chinese medicine for treating the diabetes, disclosed by the invention, is good in effect, low in cost and little in side effect.

The invention provides a traditional Chinese medicinal composition for enlivening spleen, reducing fever and promoting the secretion of the body fluid. The invention also discloses the process for preparing the pharmaceutical composition, which is a safe and effective antihypelipidemic medicament suitable for non-insula dependent diabetes patients.

The invention discloses application of L-arabinose in preparing medicines or health-care products for preventing or treating metabolic syndrome, and in particular application of L-arabinose in preparing medicines or health-care products for simultaneously reducing total cholesterol, triglyceride, fasting blood-glucose, blood pressure, waistline and weight, blood uric acid and glutamic-pyruvic transaminase of human body. The applicant discovers that for adults, in a taking dosage range of 10-20g / person / day, total cholesterol, triglyceride, fasting blood-glucose, blood pressure, waistline and weight, blood uric acid and glutamic-pyruvic transaminase of human body can be simultaneously reduced clinically. Not only is functions of the body not damaged, but also digestion and absorption of proteins and vitamins are not affected while the indexes are simultaneously reduced, so that the purpose of improving the functions of the body and preventing and treating metabolic syndrome is realized.

The invention belongs to the field of medicines, and discloses a semen cassiae extract for reducing glucose and lipid and a preparing and quality testing method thereof. The extract is a product prepared through ethanol water extraction and large-pore resin purification with semen cassiae as the raw medicine material. The quality testing method of the extract includes the step of finitely detecting the property and content. In the step of finitely detecting the content, the contents of two anthraquinone components and three naphthopyranone components in the semen cassiae extract are measured at the same time through an efficient liquid chromatography method, and the methodological inspection result is good. It is provided through a pharmacological experiment that the semen cassiae extracthas a good glucose and lipid reducing function and can be used for preparing medicines and healthcare products for reducing glucose and lipid. The preparing method is stable and reliable, the qualitycan be controlled, the medicine effect is remarkable, and the semen cassiae extract has good development and application prospects.

The invention discloses an edible composition, a low glycemic index nutrition powder and a preparation method of the edible composition and the low glycemic index nutrition powder. The edible composition comprises the following components in parts by weight: 10-16 parts of isomaltulose and 4-9 parts of resistant dextrin; isomaltulose and resistant dextrin are adopted for compounding and using under a specific ratio, so that not only the liquidity of the prepared low glycemic index nutrition powder can be obviously improved, the quality uniformity of the nutrition powder is further improved, but also the brewing performance of the nutrition powder is improved, complete dissolving can be realized in a short nutrition powder brewing time period, no caking or precipitating is caused; and in addition, the taste and flavor of the nutrition powder can be improved, the preparation process is simple, and the raw materials are easily available, so that the nutrition powder with low GI, balancednutrition, good fluidity, good reconstituability and good flavor is suitable for patients with diabetes, and is prepared.

The invention relates to a stuffed fried dough twist being capable of lowering fasting blood-glucose and increasing glucose tolerance and having a glycose metabolism regulating function as well as a production method thereof. The fried dough twist comprises a wrapper and stuffing in the mass ratio of 9:(1-8). According to the fried dough twist, wheat flour is partially replaced by wheat fibers, the content of protein in ingredients is decreased, the content of amino acid is further decreased, the Maillard reaction during production is weakened, and the fried dough twist is light in color and attractive in appearance and can promote the appetite of people; compared with common fried dough twists, the fried dough twist can lower the fasting blood-glucose and increase the glucose tolerance, the formula and the production method of the fried dough twist are proper, and effective components are well protected; compared with the common fried dough twists, the fried dough twist can lower the fasting blood-glucose and increase the glucose tolerance and is more suitable for diabetes and health-conscious people, the fried dough twist is suitable for more people, the market blank is filled up, and the relation between healthy diets and high-sucrose food is promoted to a new level.

The invention relates to the field of biological medicines, in particular to an application of nicotinamide mononucleotide in preparation of a medicine for preventing, improving and / or treating the polycystic ovarian syndrome (PCOS). A PCOS rat model is constructed by combining letrozole with high-fat feed, the protective effect of the nicotinamide mononucleotide on the PCOS is studied, and experimental results show that nicotinamide mononucleotide intervention can obviously improve the follicular development condition of PCOS rats, increase the number of corpus luteum, thicken granular cell layers, restore the oestrus cycle of the rats, reduce body weight and fasting blood sugar, reduce serum androgen, luteinizing hormone, insulin and insulin resistance index level, increase secretion oflactic acid and ATP, and improve ovarian energy metabolism.

The invention provides a medicated food composition used for adjusting and assisting of blood glucose lowering. The raw materials comprise a blood glucose lowering composition, a conditioning composition and a detoxifying composition, specifically, 40-60 % of the blood glucose lowering composition, 30-50 % of the conditioning composition, and 1-20 % of the detoxifying composition, wherein the blood glucose lowering composition comprises fructus momordicae charantiae, folium mori, radix puerariae and L-arabinose, and the ratio of fructus momordicae charantiae to folium mori and radix puerariaeto L-arabinose is 2 to 2.2 to 1.1; the conditioning composition comprises fructus mori, radix astragali, radix ginseng, poria cocos and rhizoma polygonati, and the ratio of fructus mori to radix astragali, poria cocos and rhizoma polygonati to radix ginseng is 1 to 5 to 1.6; the detoxifying composition comprises corn stigma. The invention further provides a preparation method of the medicated foodcomposition. According to the medicated food composition, the ingredients are reasonably compounded, blood glucose is reduced in a synergistic manner, the efficacy of reducing blood glucose is improved, meanwhile, the effects of tonifying the liver and the kidney, replenishing blood, and tonifying Qi are achieved, the body is regulated from many aspects, the immunity is improved, and the cure rate for diabetes is improved to 98%.

The invention provides an application of tetrahydrocurcumin in preparation of medicaments for preventing or / and treating hypertension. The invention further provides a medicinal composition for preventing or / and treating the hypertension. The tetrahydrocurcumin has the effects of reducing weight, fasting blood-glucose, triglyceride and cholesterol as well as blood pressure for experimental metabolic syndrome rats.

The invention relates to an active part of lysimachia trientaloides Hemsl.. The active part of the lysimachia trientaloides Hemsl. may be one or any combination of a petroleum ether part, an ethyl acetate part or an n-butyl alcohol part of the lysimachia trientaloides Hemsl. extracts. The extraction method particularly comprises the following steps of: lixiviating dry lysimachia trientaloides Hemsl. powder with methanol or ethanol aqueous solution; concentrating the immersion liquid to obtain an extractum; dispersing the extractum into distilled water; extracting by using the solvents of petroleum ether, ethyl acetate part and n-butyl alcohol sequentially for three times respectively; and volatilizing the solvents to obtain the petroleum ether part, the ethyl acetate part and the n-butyl alcohol part respectively. The active part of the lysimachia trientaloides Hemsl. has high inhibition activity on alpha-glucosidase and good curative effect on the mesoxyalyurea induced diabetes mice,and can be used for preparing medicines for reducing blood sugar.

The invention discloses an effective fraction of plantain seeds, as well as a preparation method and an application thereof. The effective fraction of plantain seeds is obtained by separating and purifying a plantain seed ethanol extract with a macroporous resin and contains hispidulin A and acteoside; and the weight ratio of hispidulin A to acteoside ranges from 1:1 to 1:5 and the sum weight of hispidulin A and acteoside accounts for 40% to 80% of the total weight of the effective fraction. The effective fraction of plantain seeds, disclosed by the invention, can promote the secretion of insulin and reduce fasting blood-glucose levels and can also effectively reduce blood pressure in animals and reduce blood plasma angiotensin II level, shows good medicinal values in treatment of diabetes and hypertension, and can be used alone or in combination with pharmaceutically-acceptable carriers to prepare pharmaceutical formulations for treating diabetes and / or hypertension.

The invention discloses a dietary fiber composition. The dietary fiber composition is prepared from, by weight, 30-83% of highland barley powder, 10-30% of inulin, 5-20% of konjaku flour and 2-20% ofchia seed powder. Animal test results show that the dietary fiber composition has the effects of losing weight and reducing blood glucose and lipid, and cannot cause excessive weight loss or weaknessof mice after being eaten. Human feeding trial results show that the dietary fiber composition can significantly reduce the BMI index of obesity groups, half a year after the dietary fiber compositionstops being eaten, the BMI index does not rebound, and therefore the dietary fiber composition has a better healthcare effect.

The invention provides an Enteromorpha-containing diabetes-improving health food and a preparation method thereof. The enteromorpha-containing diabetes-improving health food mainly contains extract of Enteromorpha, pelvetia siliquosa, undaria pinnatifida, sargassum, bladder-wrack, eucheuma, bitter melon, winter wheat, wolfberry, walnut, Gorgon fruit, coix seed and unprocessed rehmannia root. The functional food is prepared from effective extract of edible and medical materials derived from marine and land through compounding. A pharmacodynamic verification result shows that the functional food can significantly reduce the fasting blood glucose value of diabetes, realize prevention and adjuvant treatment on diabetes and can be processed into capsules, granules, tablets, pills or a solution.

The invention discloses a novel application of iCRT14, and particularly relates to a novel application of iCRT14 in preparation of a drug for treating type 2 diabetic cardiomyopathy. In the research, the inventor of the application finds that: the iCRT14 can reduce the blood sugar of the type 2 diabetic cardiomyopathy, improve myocardial remodeling of the type 2 diabetic cardiomyopathy, improve cardiac contraction and diastolic dysfunction caused by the type 2 diabetic cardiomyopathy and inhibit myocardial cell hypertrophy induced by high glucose and high insulin, and has a good treatment effect on the type 2 diabetic cardiomyopathy. The invention provides a new drug choice for treatment of the type 2 diabetic cardiomyopathy.