The invention provides constipation prevention and treatment formula milk powder suitable for women in a pregnancy preparation period and a gestation period. The formula milk powder is prepared by blending of skim milk powder, demineralised whey powder, vegetable fatty powder, whole milk powder, concentrated whey protein powder, fructo-oligosaccharide, phospholipids, DHA algae oil powder, choline bitartrate, lactoferrin powder, potassium chloride, calcium carbonate, magnesium oxide, zinc gluconate, ferric pyrophosphate, sodium selenite and various vitamins. The formula milk powder has advantages that nutritional requirements of fetal development and women in the pregnancy preparation period and the gestation period can be comprehensively met while excessive weight increase caused by food intake increase for nutrition supplementing can be avoided. In addition, the formula milk powder is great in taste and can be mixed with warm water, thereby being an optimum nutritional product for supplementing essential nutrients to fetuses and women in the pregnancy preparation period and the gestation period to promote fetal normal development and health of pregnant women.