The invention relates to the cream and the ointment of
Letrozole tablet
percutaneous administration and the preparation method of the cream and the ointment thereof, and relates to the cream and the ointment of the
percutaneous administration and the preparation method of the cream and the ointment thereof. The invention solves the problems that the prior
Letrozole tablet oral preparation cannot avoid the
first pass effect of liver and the bad reaction is numerous. The cream and the ointment of the
percutaneous administration are characterized in that the cream and the ointment of the percutaneous administration comprise raw materials and penetrating agent with the following percentages: 0.01 to 20 percent of
Letrozole tablet and 0.1 to 20 percent of percutaneous penetrating agent. The invention has the method that through vitro and a
skin penetration test, the Letrozole tablet only with oral preparation is filtered out a formula with good non-
steady state /
steady state distribution by a
skin release curve, and then the cream and the ointment of the percutaneous administration are prepared, so as to lead principal
medicine to avoid the liver
first pass effect of
oral administration to directly reach
mammary gland target tissue, and to lead the concentration of
target tissue internal medicine to be improved. Compared with the prior preparation at home and at abroad, the invention technically has the advantages that the prepared external preparation can reduce the
side effect of Letrozole tablet and improve the
curative effect of the Letrozole tablet, thereby the invention has good promotion and application value.