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Letrozole transdermal drug administration plaster and its preparation method

A technology of transdermal drug delivery and letrozole, which is applied in the direction of antineoplastic drugs, drug combination, sheet delivery, etc., can solve the problems of short effective time, many adverse reactions, frequent drug administration, etc., and achieve stable absorption and non-toxicity Side effects, effects of reducing the number of administrations

Inactive Publication Date: 2007-03-14
哈尔滨健迪医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to solve the problems of short effective time, frequent administration and many adverse reactions of letrozole in the treatment of postmenopausal late stage in the existing dosage forms of letrozole, and a kind of letrozole transdermal administration is provided Patch and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0010] Specific embodiment one: the letrozole transdermal drug delivery patch of this embodiment is made up of matrix layer, backing layer and protective film; The matrix layer of letrozole transdermal drug delivery patch comprises letrozole, adhesive and organic Solvent; letrozole accounts for 0.5% to 40% of the mass of the patch matrix layer, the adhesive accounts for 10% to 90% of the mass of the patch matrix layer, and the balance is an organic solvent; wherein the organic solvent is ethyl acetate, ethanol, acetone, One or a combination of propylene glycol.

[0011] The matrix layer of the letrozole transdermal drug delivery patch of this embodiment has good compatibility and adhesion with the skin, and the long-term stability test proves that the active ingredient content, in vitro release rate and adhesion characteristics of the matrix layer have not occurred. The obvious change indicates that the matrix layer has good stability.

specific Embodiment approach 2

[0012] Specific embodiment two: in this embodiment, the backing layer is non-woven fabric, elastic cloth, composite aluminum foil, polyester film, paper, polyvinyl chloride film, polyethylene film, polypropylene film or polyethylene terephthalate ester. In this embodiment, the protective film is siliconized paper, polyethylene film, polystyrene film, polypropylene film, polycarbonate film or polytetrafluoroethylene film.

specific Embodiment approach 3

[0013] Specific embodiment three: The matrix layer of the letrozole transdermal drug delivery patch of this embodiment also includes plasticizers accounting for 0.1% to 20% of the mass of the patch matrix layer, 0.1% to 20% of tackifiers, 0.1 %-20% transdermal absorption enhancer and / or 0.1%-10% crystallization inhibitor. Others are the same as the first embodiment.

[0014] In this embodiment, the area is 5-60 cm 2 The daily drug delivery rate of the patch matrix layer is 1-8mg.

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Abstract

Letrozole cutaneous penetration patch and its preparation method, it involves a cutaneous penetration patch and the patch preparation methods. The invention solves problems of the present Letrozole available dosage form drugs in the treatment of postmenopausal women with advanced aspects in short effective time, frequent administration, a more dverse reactions. It consists of matrix layer, back lining and protective film. The matrix layer of letrozole cutaneous penetration patch includes letrozole, adhesives and organic solvents. Their preparation methods: (a) spraid the mixture of letrozole, adhesives and organic solvents evenly on the back lining; (b) after they are dried, cover the protective membrane on the other surface of the patch matrix layer, then the letrozole cutaneous penetration patch is obtained. The patches matrix layer of the invention has good compatibility and adhesiveness with skin, good stability. The invention of the patches maintains constant speed, uniform release, obvious treatment results and long effective time, long recurrence interval, low recurrence rate. Preparation of the present invention patch method is simple and easy to operate.

Description

technical field [0001] The invention relates to a patch and a preparation method thereof. Background technique [0002] Transdermal drug delivery systems (trandermal therapeutic systems, TTS) are administered on the surface of the skin so that the drug enters the blood at a constant rate (or close to a constant rate) through the skin without accumulating under the skin, which is different from preparations that act on the skin or subcutaneous local tissues (such as Ointment, plaster, paint and aerosol, etc.) have the following advantages: (1) Avoid the liver first-pass effect and gastrointestinal inactivation that may occur after oral administration, improve the therapeutic effect, and reduce toxic and side effects; transdermal administration At this time, the drug can continue to diffuse into the blood circulation for a long time. (2) The drug is controlled to be released at a near constant rate, enters the human circulation, fully exerts the therapeutic effect of the drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/4196A61P5/32A61P35/00
Inventor 张艳红徐静
Owner 哈尔滨健迪医药技术有限公司
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