74results about How to "Give full play to the therapeutic effect" patented technology

The invention discloses an oral prednisone time-selecting release preparation and a preparation method thereof. The oral prednisone time-selecting release preparation provided by the invention mainly consists of 0.3-5 parts of prednisone and derivatives thereof, 10-50 parts of glyceryl behenate and 3-30 parts of hydroxypropyl cellulose, and can further contain a disintegrating agent and other pharmaceutically acceptable excipients. The preparation method is as below: extruding tablet cores or granules containing the drug according to the formula by a tablet press or a dry granulator; and coating the tablet cores or particles containing the drug by a coating pan or a fluidized bed to attach the coating film to the tablet cores or particles containing the drug, so as to obtain the oral prednisone time-selecting release preparation. The oral prednisone time-selecting release preparation provided by the invention can achieve a good balance between the biological rhythm of the patients and the curative effects, and is safer, more convenient and effective compared with a traditional preparation. The oral prednisone time-selecting release preparation is prepared by an extrusion-coating process, which is simple for operation, and the obtained time-selecting release preparation has the advantages of drug stability and high reproducibility.

The invention discloses a preparation of pinellia decoction for purging stomach fire, its preparing method and application, wherein the preparation comprises using compound pinellia decoction as raw medicinal materials, extracting effective substances with water or ethanol, preparing powdered extract through spray drying or decompression drying, charging medicinal auxiliary materials and preparing granule through dry method palletizing or wet method palletizing, finally filling into capsule or carrying pelleting to form the tablet. The preparation has good curative effect for superficial gastritis especially gastritis caused by Helicobacter pylori, and gastric ulcer, the invention also has the advantages of easy administration and small amount of dosage.

The invention discloses a tanshinol lipidosome bone-targeting pharmaceutical preparation and a preparation method thereof. The preparation is prepared by jointing and carrying out surface modification on a lipidosome microparticle containing a tanshinol medicine molecule by using a bone-targeting jointer. The preparation method comprises the steps of jointing a bisphosphonate molecule with bone-targeting ability on one end of a polyethylene glycol molecule through synthetic reaction, and jointing a cholesterol molecule serving as a lipidosome raw material on the other end of the polyethylene glycol molecule through synthetic reaction to prepare a jointer with bone-targeting ability, namely bisphosphonate-polyethylene glycol-cholesterol (BP-PEG-CHOL); and then, preparing a lipidosome provided with the bone-targeting jointer on the surface from phospholipid, cholesterol and the bone-targeting jointer which serve as raw materials, adding tanshinol, and containing the tanshinol into the lipidosome to prepare the tanshinol lipidosome bone-targeting preparation. The preparation disclosed by the invention has the bone-targeting ability and can be used for remarkably increasing the concentration of medicines in a bone tissue, improving the curative effect and preventing and treating systemic metabolic bone diseases, osteoporosis and bone fracture.

Letrozole cutaneous penetration patch and its preparation method, it involves a cutaneous penetration patch and the patch preparation methods. The invention solves problems of the present Letrozole available dosage form drugs in the treatment of postmenopausal women with advanced aspects in short effective time, frequent administration, a more dverse reactions. It consists of matrix layer, back lining and protective film. The matrix layer of letrozole cutaneous penetration patch includes letrozole, adhesives and organic solvents. Their preparation methods: (a) spraid the mixture of letrozole, adhesives and organic solvents evenly on the back lining; (b) after they are dried, cover the protective membrane on the other surface of the patch matrix layer, then the letrozole cutaneous penetration patch is obtained. The patches matrix layer of the invention has good compatibility and adhesiveness with skin, good stability. The invention of the patches maintains constant speed, uniform release, obvious treatment results and long effective time, long recurrence interval, low recurrence rate. Preparation of the present invention patch method is simple and easy to operate.

The present invention discloses one kind of compound Tibetan fennel capsule for treating indigestion and its preparation process. The compound Tibetan fennel capsule contains Tibetan fennel oil and mint oil in effective treating amount, the Tibetan fennel oil contains carvol over 50 wt% and limonene over 35 wt%, and the mint oil contains menthol over 25 wt%. The preparation process of the compound Tibetan fennel capsule includes mixing medicine liquid, encapsulating and other steps. The experiments show that medicine of the medicine has determined curative effect, high bioavailability, high safety, high reliability and other features.

The invention provides a medicine composite for treating chronic kidney diseases. The medicine composite is prepared from the following traditional Chinese medicines in parts by weight: 25-75 parts of astragalus, 5-15 parts of panax notoginseng, 5-15 parts of angelica sinensis, 15-45 parts of achyranthes, 15-45 parts of hallus laminariae, 5-15 parts of oyster and 3-9 parts of rhubarb. The invention also provides a preparation method and application of the medicine composite. The medicine composite is used for treating various chronic kidney diseases such as primary nephrotic syndrome and tubulointerstitial fibrosis and supplies a new choice to clinic due to definite medicinal effects.

A vaginal effervescent tablet of miconazole nitrate is proportionally prepared from miconazole nitrate, tartaric acid, sodium dicarbonate, microcrystalline cellulose, polysorbitate, carboxymethyl starch sodium and magnesium stearate.

The invention relates to a medicament for treating metrorrhagia and metrostaxis, hematemesis, hematochezia and traumatic hemorrhage and a preparation method thereof. The preparation method comprises the following steps of: 1, mixing rhubarb, golden thread and dahurian angelica root, adding an ethanol, merging ethanol extract, and concentrating the ethanol extract; 2, adding sanchi into the ethanol, merging ethanol extract and concentrating the ethanol extract; 3, taking common bletilla pseudobulb decocting liquid and concentrating the liquid into a thick paste with a relative density between 1.15 and 1.30 at the temperature of 60 DEG C; 4, decocting dregs in the three steps, India madder root and liquoric root twice, merging decoction, concentrating the decoction, mixing the concentrated decoction with the thick paste obtained in step 3, reducing pressure and drying the mixture to obtain a dry paste and crushing the dry paste; 5, evenly mixing products obtained by step 1 and step 2, carrying out high-speed centrifugal spraying drying, and simultaneously spraying aqueous solution of hydroxypropyl-beta-cyclodextrin to prepare dispersed fine powder; and 6, mixing and crushing medicaments such as cuttlebone, calcined dragon bone and the like, evenly mixing the mixture with two fine powder obtained by the step 4 and step 5, adding medicaments such as microcrystalline cellulose and the like, and evenly mixing, drying and palletizing the mixture. The medicament simplifies production process, saves production cost and has obvious curative effect.

The invention discloses a phlegm dissolving and cough quenching paste and belongs to the technical field of medical preparations. The traditional Chinese medicine raw materials consist of the following substances in part by weight: 2-10 of sinapis alba, 1-6 of ephedra, 1-5 of euphorbia kansui, 1-4 of araceae, 0.5-4 of corydalis, 0.5-4 of asarum and 1-4 of castor bean oil. The phlegm dissolving and cough quenching paste is prepared by the method that traditional Chinese medicines in the traditional Chinese medicine raw materials except the castor bean oil are pulverized, blended with the castor bean oil, uniformly mixed and pasted on rubberized fabric. The phlegm dissolving and cough quenching paste has the functions of ventilating the lung, relieving cough, dispelling phlegm and preventing asthma and is mainly used for treating chronic obstructive pulmonary diseases and cough symptoms, such as cough, phlegm coughing and breath shortness.

The invention belongs to the field of traditional Chinese medicines and particularly relates to an application of traditional Chinese medicine composition and a preparation thereof in preparation of adrug for treating ALI (acute lung injury). The traditional Chinese medicine composition is prepared from raw materials such as rhizoma paridis, radix scutellariae, thunberg fritillary bulb, common dayflower herbs, rhizoma anemarrhenae, gypsum, dried tangerine or orange peel, fructus aurantii, fructus xanthii, bitter almond kernels, radix platycodonis, cablin potchouli herbs, folium perillae and prepared liquorice roots. Study results show that the traditional Chinese medicine composition can reduce the water content and the permeability index of the lung of a model rat with ALI and reduce thelevel of cell inflammatory factors, improve change of ALI lung histopathology, has a remarkable treatment effect on ALI and is suitable for clinical popularization and application.

The invention relates to a new preparation formulation using high-quality pure paper (or containing medicament) to be made into paper patch and particular applied to local oral cavity. The paper patch is formed by making a soft paperboard by 36-48 layers of paper with 0.15-0.2cm and cutting into the shape of rectangular strip with 3cm length and 1.2cm width. The paper patch has stronger absorbency, adsorbability, adsorption polymerization (adsorbing and polymerizing antibiosis substances of saliva and gingival crevicular fluid), and hemostatic and protective properties, can getter bacterium, endotoxin and inflammatory cytokines, as well as suppuration smell and bacterial plaque. The new preparation formulation has the functions of eliminating inflammation to stop pain, and stopping bleeding and diminishing swelling, further can protect the mucosa barrier of the oral cavity so as to be free from of invasion of bacterium and endotoxin on the blood and cause cardio-cerebrovascular diseases. Shown by initial trial, the new preparation formulation has tremendous curative effect on toothache. The medicament-containing paper patch can have the effect of being fast in action and high in curative effect, reducing adverse reaction and improving safety. When being used in hypogloeeis, the paper patch provides a novel hypogloeeis paper patch for hypogloeeis administration for treating intracorporal disease, especially cardiovascular disease and respiratory system disease. The product has no adverse effect, is absolutely safe, simple to administrate, no smell and stimulation, and good mouthfeeling, and can be popular with any people. The product is easy to produce, rich in raw materials and low in cost.

The invention belongs to the technical field of medicine and particularly relates to trimetazidine hydrochloride tablets and a preparation method thereof. The trimetazidine hydrochloride tablets are prepared from raw materials as follows: trimetazidine hydrochloride, filler, a binder, a lubricant and a wetting agent. The trimetazidine hydrochloride tablets solve the problems of poor compressibility and difficulty in forming of the trimetazidine hydrochloride as the raw material. The invention further provides the preparation method of the trimetazidine hydrochloride tablets. The compressibility of the prepared trimetazidine hydrochloride tablets is improved, the trimetazidine hydrochloride tablets are formed easily, the use value of the trimetazidine hydrochloride tablets can be increased better, trimetazidine hydrochloride is prepared into tablets to facilitate taking of a patient, pain of the patient can be relieved timely, the process is simple, the quality is stable, a production process meets the requirement of GMP (Good Manufacture Practice of Drugs), and the trimetazidine hydrochloride tablets and the preparation method are applicable to industrial mass production.

The invention discloses a khosam oil suppository. An active component of khosam oil of the khosam oil suppository of the invention is loaded in a matrix in a form of particles. The khosam oil suppository of the invention has the advantages of both suppositories and particles, not only is suitable for rectal administration or vaginal administration to generate local and systemic effect, can effectively prevent adverse reactions of khosam oil, but also can control the drug release speed, give full play to the drug curative effect, and significantly improve patient compliance, and has significant treatment superiority when compared with commercially available khosam oil products and traditional common khosam oil suppositories.

A Chinese medicine for treating the gynecologic inflammation is prepared from 8 Chinese-medicinal materials including patrinia herb, green chiretta, Chinese angelica root, cyprus tuber, etc by supercritical CO2 extracting, microwave drying and superfine pulverizing. Its preparing process is also disclosed.

The invention discloses a fresh cooking technology of cucumbers without additives. The technology is characterized by including the following steps of raw cucumber checking, cucumber unfreezing, primary cooking, gutting and cutting, secondary cooking, cucumber soaking, quick freezing, packaging, inspection and finished product obtaining. By means of the fresh cooking and processing technology of cucumbers, the whole processing process is conducted in a normal-temperature and normal-pressure environment, no additives are added, water swelling does not happen, the problem that a lot of nutrients in cucumbers are lost in a high-temperature and high-pressure cucumber processing method is solved, and nutrients in the cucumbers can be fully maintained. The cucumbers are safe to eat, delicious in taste and easy to digest and absorb, and the dietary therapy function of the cucumbers are given full play of easily.

Buprenorphine and or buprenorphine hydrochloride patch base material and preparation for said patch is presented, relating to a patch base material and preparation there of. Its preparation process is: 1) after mixing evenly Buprenorphine and or buprenorphine hydrochloride, adhesive and organic solvent, spreadin thereof evenly on lining cloth; 2) after drying, spreading protective film on to the other side of base material to obtain hereinabove said patch.

A Chinese medicine for preventing and treating fatty liver is prepared from 17 Chinese-medicinal materials. Its preparing process is also disclosed.

The invention relates to a traditional Chinese medicine composition for treating cancer. The traditional Chinese medicine composition is mainly prepared from raw material medicines of cordyceps sinensis, saffron, ginseng, scorpion, centipede, bear gall powder, glossy privet fruit, licorice and rhizoma polygonati, and an oral preparation prepared from the traditional Chinese medicine composition and additives includes powder, tablet, capsule or pill; the invention further relates to a preparation method of the traditional Chinese medicine composition and the preparation thereof. The traditional Chinese medicine composition provided by the invention is mainly used for treating primary liver cancer, lung cancer, colorectal cancer, lymphatic cancer, esophageal cancer, gastric cancer, cardia cancer, pancreatic cancer, breast cancer, uterine cancer and leukopenia; the traditional Chinese medicine composition has the advantages of being quick to become effective, high in cure rate, free of recurrence after cure and few in toxic side effects.

The invention belongs to the technical field of veterinary drugs and discloses a preparation method of a compound sulfachloropyrazine sodium suspension. The suspension comprises sulfachloropyrazine sodium, sodium hydroxyethyl cellulose, tween-80, EDTA-Na2, a synergist, a preservative and a solubilizer. The preparation method comprises the steps of mixing 1 / 3 volume dose of solubilizer with the preservative, and then adding the sodium hydroxyethyl cellulose; adding the rest solubilizer into the EDTA-Na2, adding water for dilution, and finally adding the sulfachloropyrazine sodium and stirring for dissolution; mixing the solutions, adding the tween-80 and suspending with the synergist to obtain the compound sulfachloropyrazine sodium suspension. According to the method disclosed by the invention, by selecting scientific suspending aid, solubilizer, preservative and metal complexing agent, the medicine of the dosage form does not generate accumulative precipitate after long-time standing, so that the medicine is uniformly distributed in an aqueous phase and can be synchronously absorbed in an administration process, thus the disease treatment requirements are met, and the treatment effect is sufficiently realized.

The invention discloses a traditional Chinese medicine for treating viral hepatitis. The traditional Chinese medicine consists of the following traditional Chinese medicinal materials in parts by weight: 20 to 25 parts of jasminum amplexicaule, 25 to 30 parts of lysimachia christinae, 15 to 20 parts of giant knot weed, and 15 to 20 parts of serissa. The traditional Chinese medicine can be used for regulating human immunity, inhibiting autoimmune response, dredging liver blood capillary, bile capillary and the like, so that the traditional Chinese medicine can smoothly enters into tissue cells of each part and sufficiently play the effect of treatment. The traditional Chinese medicine is prepared by hereditary secret formula in Chinese Yao nationality through scientific verification, consists of pure natural herbal traditional Chinese medicines, has the advantages of simple medicinal materials, quick response and no side effect, and is convenient to take.

The invention discloses a medicine preparation containing 5-fluorouracil drug eutectic with nicotinamide as a precursor and a preparation method of the medicine preparation.5-fluorouracil raw material medicine is selected as medicine API, nicotinamide serves as the medicine precursor, a liquid-phase assisted grinding method is adopted, the high-purity 5-fluorouracil drug eutectic is obtained, and the effect that the medicine can be more stable can be achieved; in addition, the invention further provides the medicine preparation containing the 5-fluorouracil drug eutectic, the medicine preparation comprises tablets, slow-release tablets, microspheres, micro-capsules, suppository, emulsion, a film agent and an injection agent so that stability and the curative effect of the 5-fluorouracil drug eutectic with the nicotinamide as the precursor can be better improved, different medicine application modes are utilized, and possibility of fully playing the treatment function of medicine and lowering or avoiding adverse reactions is provided.Auxiliaries applied to the preparation method of the preparation are easy to buy in the market and low in price, therefore cost is quite low, and the medicine application burden of patients can be remarkably lowered.

The invention relates to a salt packet for relieving human muscular pain. A medicine is arranged in the salt packet and is prepared from the following ingredients: fructus evodiae, caryophyllus aromaticus, cassia twigs, Chinese angelica, safflowers, radix angelicae, notopterygium root, radix puerariae, herba menthae, rhizoma chuanxiong, borneol and halite. According to the salt packet, the raw materials are rich, the ingredients are scientific, are reasonable in combination, support each other and are effective drugs for treating muscular soreness, swelling pain and numbness, and the salt packet is good in treatment effect, safe in medication and stable in treatment effect, is free of toxic or side effects, is safe and reliable and is an innovation on the drugs for treating the muscular soreness, swelling pain and numbness.

The invention relates to instant milk cubilose and a preparation method thereof. The method comprises the following steps of performing sterilization treatment on a cubilose raw material, and placingthe cubilose raw material in a sterile heat preservation cabinet for heat preservation; soaking the cubilose raw material subjected to heat preservation so as to obtain soaked cubilose; sequentially carrying out filtration, osmotic concentration, degreasing standardization treatment, secondary homogenization and centrifugation on milk to obtain sterilized milk; and heating the sterilized milk to 50 DEG C, carrying out stirring and hydrating for 20 minutes, continuously heating the milk to 60 DEG C, adding a stabilizer, the soaked cubilose and sugar, and carrying out sterilizing treatment to obtain the instant milk cubilose. By using the method provided by the invention, the instant milk cubilose which retains the color and taste of the milk and has the relatively long shelf life can be obtained.

The invention discloses a colon-targeted drug delivery preparation of hemalbumin polypeptide, which is an orally taken preparation for releasing the drug at a colon part, and prepared by coating a drug-containing pellet containing the hemalbumin polypeptide component with colon-targeted coating liquor or directly filling the drug-containing pellet into a colon-targeted capsule shell, wherein the drug-containing pellet consists of the following components in parts by weight: 60-92 parts of drug powder containing the hemalbumin polypeptide component, 5-25 parts of sucrose, 3-15 parts of povidone K30; and the drug powder comprises the following components in parts by weight: 10-100 parts of hemalbumin polypeptide and 0-90 parts of other drugs and / or nutrients. The preparation disclosed by the invention is a colon release drug with target zone drug concentration higher than that of other tissues, enters blood circulation through the colon, can effectively avoid metabolism destruction of peptide drugs of common orally-taken preparation in the stomach to bring treatment effect of the drug into full play, and is safe and convenient to take orally.

The invention discloses a kidney tonifying and hair blacking composition and application thereof. The kidney tonifying and hair blacking composition is prepared from 30-80 parts of radix rehmanniae preparata, 30-80 parts of rhizoma dioscoreae, 30-80 parts of semen cuscutae, 30-80 parts of walnut kernels, 20-40 parts of rhizoma polygonati, 20-40 parts of flatstem milkvetch seeds, 10-20 parts of cortex moutan, 10-20 parts of rhizoma alismatis, 10-20 parts of rhizoma gastrodiae, 10-30 parts of fructus corni, 5-15 parts of radix angelica sinensis, 5-15 parts of flos carthami, 5-15 parts of sargentgloryvine stems, 30-80 parts of radix polygoni multiflori preparata, 30-80 parts of black sesame seeds, 30-80 parts of black soya beans and 10-30 parts of chicken's gizzard-membrane. The application of the kidney tonifying and hair blacking composition to preparation of hair blacking drugs, hair blacking healthcare foods or hair blacking foods is also provided. Due to the fact that the prescription contains radix rehmanniae preparata, rhizoma dioscoreae, semen cuscutae, walnut kernels, rhizoma polygonati, flatstem milkvetch seeds, radix polygoni multiflori preparata, black sesame seeds, black soya beans and other kidney tonifying traditional Chinese medicines as well as liver tonifying traditional Chinese medicines like fructus corni and radix angelica sinensis, the purposes of tonifying kidney and liver and replenishing essence and blood can be realized, and the effect of blacking hair and beard is realized fundamentally.

The invention discloses a prednisone oral pulsatile tablet and a preparation method thereof. The oral pulsatile tablet comprises a rapid-release tablet core, a swelling coating layer and a controlled-release film coating layer, wherein the rapid-release tablet core is composed of a main medicine and pharmaceutically acceptable auxiliary materials, the main medicine is pulsatile, the dosage specification is 1-20mg per tablet metered by pulsatile, and the tablet core weight is 120-220mg; the swelling coating layer is composed of hydroxypropyl methylcellulose, and the coating weight increment relative to the weight of the rapid-release tablet core is 1-20%; the controlled-release film coating layer is composed of a water-insoluble film coating material which is insoluble under different pH values and other pharmaceutically acceptable auxiliary materials, and the coating weight increment relative to the total weight of the rapid-release tablet core and the swelling coating layer is 1-15%. According to the prednisone oral pulsatile tablet and the preparation method thereof disclosed by the invention, the tablet core is prepared by a direct powder tableting process, the swelling coating layer and the controlled-release layer are prepared by a film coating method, the preparation is stable, and the process is simple and practicable, and high in reproducibility.

The invention provides a targeting nanomaterial with a cell membrane coated with Au-Fe3O4 as well as a preparation method and application of the targeting nanomaterial, belonging to the technical field of targeting nanomaterials. The targeting nanomaterial provided by the invention comprises a cancer cell membrane, Au-Fe3O4 nanoparticles, tannic acid and phorbol 12-myristate 13-acetate, wherein the Au-Fe3O4 nanoparticles, the tannic acid and the phorbol 12-myristate 13-acetate are wrapped in the cancer cell membrane. PMA can effectively stimulate cells to generate H2O2 and active oxygen O2 <->, can supplement insufficient H2O2 in cancer cells, and can supplement raw materials for Fenton reaction; the Fe3O4 can be partially decomposed in the presence of the tannic acid to form Fe<2+> and Fe<3+>, Fe<2+> can catalyze H2O2 in the cancer cells to be decomposed into hydroxyl radicals, and TA can promote rapid conversion of Fe<3+> generated by Fe3O4 into Fe<2+>; and meanwhile, Au and Fe3O4 have good photo-thermal conversion efficiency, and can give full play to the therapeutic effect of PTT.

The invention discloses a novel metformin hydrochloride solid medicinal preparation and a preparation method thereof. The novel metformin hydrochloride solid medicinal preparation comprises, by weight, 300-800 parts of metformin hydrochloride as a main drug of a tablet core, 100-500 parts of auxiliary materials and 100-300 parts of coating materials, wherein the auxiliary materials comprise a filling agent, a disintegrating agent, a bonding agent and a lubricating agent, and the coating materials comprise 5-60 parts of gastric-soluble type polymethacrylate and 80-240 parts of enteric-soluble type polymethacrylate. The specific preparation method comprises the following steps that 1, after the main drug is mixed with the filling agent and the disintegrating agent, the bonding agent is added into the mixture, and a soft material is prepared; 2, the soft material is sieved to form granules, and the granules are dried; 3, after drying, the lubricating agent is added into the dried granules and mixed to be uniform, the tablet cores are formed through pressing; 4, coating is performed, the weight is increased by 5%-20%, and then the novel metformin hydrochloride solid medicinal preparation is obtained. The novel metformin hydrochloride solid medicinal preparation has the advantages that the limitation that existing listed preparations can only be absorbed in the stomach or the intestinal canal is overcome, the medicinal preparation is released in a balanced mode in a certain time, the medicinal preparation is absorbed continuously and stably, the medicinal preparation concentration in the blood is maintained for a long time, so that the optimal treatment effect is achieved, the treatment effect of the medicinal preparation is fully played, and meanwhile the untoward effect is reduced.