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Buprenorphin and/or buprenorphin hydrochloride plaster substrate and its preparing method for plaster

A technology of buprenorphine hydrochloride patch and buprenorphine hydrochloride, which is applied in the field of preparation of patch matrix and patch, can solve the problem of blood drug concentration peak and peak valley fluctuation, poor analgesic effect, and many adverse reactions And other issues

Inactive Publication Date: 2007-04-11
哈尔滨健迪医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the defects of peak and peak and valley fluctuations in blood concentration, many adverse reactions and poor analgesic effect during the administration of buprenorphine and / or buprenorphine hydrochloride preparations at present, and provides a kind of Buprenorphine and / or buprenorphine hydrochloride patch base and preparation method of the patch

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0004] Specific embodiment one: present embodiment buprenorphine and / or buprenorphine hydrochloride patch matrix comprises pharmaceutical composition, adhesive and organic solvent; Pharmaceutical composition is buprenorphine and / or buprenorphine hydrochloride patch 0.5%-40.0% of the mass of the matrix, the adhesive accounts for 40%-90% of the mass of the patch matrix, and the balance is an organic solvent.

[0005] The buprenorphine and / or buprenorphine hydrochloride patch matrix of this embodiment has good compatibility and adhesion with the skin, and the long-term stability test proves the active ingredient content, in vitro release and adhesion characteristics of the matrix No significant changes occurred, indicating that the matrix has good stability.

specific Embodiment approach 2

[0006] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the buprenorphine and / or buprenorphine hydrochloride patch matrix also includes plasticizers accounting for 0.1% to 20% of the mass of the patch matrix , 0.1% to 20% of a tackifier, 0.1% to 20% of a transdermal absorption accelerator and / or 0.1% to 10% of a crystallization inhibitor. Others are the same as the first embodiment.

[0007] In this embodiment, the area is 5-60 cm 2 The daily drug delivery rate of the patch matrix is ​​0.5-7.5mg.

specific Embodiment approach 3

[0008] Embodiment 3: The difference between this embodiment and Embodiment 1 is that the adhesive is polyisobutylene pressure-sensitive adhesive, silicone rubber pressure-sensitive adhesive, polyacrylate pressure-sensitive adhesive or acrylic pressure-sensitive adhesive. Others are the same as the first embodiment.

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Abstract

Buprenorphine and or buprenorphine hydrochloride patch base material and preparation for said patch is presented, relating to a patch base material and preparation there of. Its preparation process is: 1) after mixing evenly Buprenorphine and or buprenorphine hydrochloride, adhesive and organic solvent, spreadin thereof evenly on lining cloth; 2) after drying, spreading protective film on to the other side of base material to obtain hereinabove said patch.

Description

technical field [0001] The invention relates to a patch matrix and a preparation method thereof. Background technique [0002] Buprenorphine is a partial opioid receptor agonist synthesized in the 1960s. It is a non-narcotic analgesic. Its analgesic ability is about 30 times higher than that of morphine and about 75 times higher than that of pentazocine. Times, and widely used to reduce cancer pain and postoperative pain and assist anesthesia, can be used as a powerful analgesic drug and heroin addiction detoxification treatment. But at present buprenorphine and / or buprenorphine hydrochloride preparations have the defects of peak and peak and valley fluctuations in blood concentration, many adverse reactions, and poor analgesic effect during the administration of buprenorphine hydrochloride preparations. Contents of the invention [0003] The purpose of the present invention is to solve the defects of peak and peak and valley fluctuations in blood concentration, many adve...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61K9/70A61K47/34A61K47/32A61K47/12A61K47/10A61P25/04
Inventor 徐静张艳红
Owner 哈尔滨健迪医药技术有限公司
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