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Plaster matrix of tolterodine tartrate and/or tolterodine fumarate and plaster preparing process

A technology of tartaric acid and fumaric acid, applied in sheet delivery, urinary system diseases, drug combination, etc., can solve the problems of overactive bladder, such as ineffective effect, short effective time, frequent medication, etc.

Inactive Publication Date: 2007-03-21
哈尔滨健迪医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the shortcomings of the current treatment of overactive bladder drugs, such as ineffectiveness, short effective time, frequent medication, and many adverse reactions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0005] Specific embodiment one: present embodiment tolterodine tartrate and / or tolterodine fumarate patch base comprise pharmaceutical composition, adhesive and organic solvent; Pharmaceutical composition is tolterodine tartrate and / or tolterodine fumarate The terodine accounts for 0.5%-40.0% of the mass of the patch matrix, the adhesive accounts for 10%-90% of the mass of the patch matrix, and the balance is an organic solvent.

[0006] Tolterodine tartrate and / or tolterodine fumarate patch matrix of the present embodiment has good compatibility and adhesion with skin, and long-term stability test proves that the active ingredient content, in vitro release rate and None of the adhesion properties changed significantly, indicating that the matrix has good stability.

specific Embodiment approach 2

[0007] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the tolterodine tartrate and / or tolterodine fumarate patch matrix also includes 0.1% to 30% of the mass of the patch matrix Plasticizer, 0.1%-30% tackifier, 0.1%-20% transdermal absorption accelerator and / or 0.1%-10% crystallization inhibitor. Others are the same as the first embodiment.

[0008] In this embodiment, the area is 5-60 cm 2 The daily drug delivery rate of the patch matrix is ​​0.5-8mg.

specific Embodiment approach 3

[0009] Embodiment 3: The difference between this embodiment and Embodiment 1 is that the adhesive is polyisobutylene pressure-sensitive adhesive, silicone rubber pressure-sensitive adhesive, polyacrylate pressure-sensitive adhesive or acrylic pressure-sensitive adhesive. Others are the same as the first embodiment.

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PUM

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Abstract

The present invention is plaster matrix of tolterodine tartrate and / or tolterodine fumarate and the preparation process of plaster for treating bladder hypermobility syndrome. The plaster matrix includes medicine component, adhesive and organic solvent. The tolterodine tartrate and / or tolterodine fumarate plaster is prepared through the following steps: 1. mixing tolterodine tartrate and / or tolterodine fumarate, adhesive and organic solvent, and smearing the mixture onto the lining layer; and 2. covering protection film onto the matrix after the matrix become dry. The tolterodine tartrate and / or tolterodine fumarate plaster is used in treating bladder hypermobility syndrome, and has high effective rate and short curing period.

Description

technical field [0001] The invention relates to a patch matrix and a preparation method thereof. Background technique [0002] Transdermal drug delivery systems (trandermal therapeutic systems, TTS) are administered on the surface of the skin so that the drug enters the blood at a constant rate (or close to a constant rate) through the skin without accumulating under the skin, which is different from preparations that act on the skin or subcutaneous local tissues (such as Ointment, plaster, paint and aerosol, etc.) have the following advantages: (1) Avoid the liver first-pass effect and gastrointestinal inactivation that may occur after oral administration, improve the therapeutic effect, and reduce toxic and side effects; transdermal administration At this time, the drug can continue to diffuse into the blood circulation for a long time. (2) The drug is controlled to be released at a near constant rate, enters the human circulation, fully exerts the therapeutic effect of t...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/135A61P13/08A61P13/10
Inventor 徐静张艳红刘臣
Owner 哈尔滨健迪医药技术有限公司
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