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Preparation method of compound sulfachloropyrazine sodium suspension

The technology of sulfachlorpyrazine sodium and suspension is applied in the field of preparation of compound sulfachlorpyrazine sodium suspension, and can solve the problems of inability to perform uniform administration, high treatment cost, accumulation of poisoning and the like

Inactive Publication Date: 2014-06-04
QINGDAO BOITE BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the treatment of coccidiosis, it is generally administered orally, but there is a difference in the water solubility of the two drugs, sulfachlorpyrazine sodium and metmethoxine, which makes it impossible to uniformly administer the drug, and the absorption rate of the drug in the animal body is different, making the The cost of treatment is high, and it is easy to cause accumulation poisoning

Method used

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preparation example Construction

[0005] The preparation method step of compound recipe sulfachlorpyrazine sodium suspension among the present invention is as follows:

[0006] 1. Add EDTA-Na 2 Add appropriate amount of water to dissolve, add 2 / 3 solubilizer, add water to dilute to 50-80ml, finally add sulfachlorpyrazine sodium, stir to dissolve;

[0007] 2. Mix the preservative and the remaining volume of the solubilizer, then add sodium hydroxyethyl cellulose, and infiltrate evenly;

[0008] 3. Add the solution obtained in step 2 to the solution obtained in step 1, and add Tween-80 at the same time, and stir until it becomes clear;

[0009] 4. Mix the synergist with the solution obtained in step 3, put it in a colloid mill and grind it for 15-30 minutes until the solution is well suspended, and dilute to 100ml with water.

[0010]

Embodiment 1

[0012] Accurately weigh:

[0013] Sulfachlorpyrazine Sodium 15g

[0014] Tween-80 0.1g

[0015] Trimethoprim 2g

[0016] Benzoic acid 0.02g

[0017] Sodium hydroxyethyl cellulose 0.5g

[0018] EDTA-Na 2 0.1g

[0019] Propylene glycol 20ml

[0020] Quantify to 100ml with purified water; wherein, the particle size of trimethoprim is ≤20μm.

[0021] Preparation steps:

[0022] (1) Add EDTA-Na 2 After dissolving with a small amount of water, add 12ml of propylene glycol, dilute to 50ml with water, add sulfachlorpyrazine sodium, stir to dissolve.

[0023] (2) Mix benzoic acid and remaining propylene glycol, add sodium hydroxyethyl cellulose, and infiltrate evenly;

[0024] (3) Mix the solutions obtained in (1) and (2), add Tween-80 at the same time, and stir until it becomes clear.

[0025] (4) Add methotrexate to the solution obtained in (3), place it in a colloid mill and grind for 15-30 minutes until the solution is well suspended, then add...

Embodiment 2

[0027] Accurately weigh:

[0028] Sulfachlorpyrazine Sodium 10g

[0029] Tween-80 0.2g

[0030] Trimethoprim 4g

[0031] Sorbic acid 0.05g

[0032] Hydroxyethyl Cellulose Sodium 1.0g

[0033] EDTA-Na 2 0.2g

[0034] Glycerin 30ml

[0035] Quantify to 100ml with purified water; wherein, the particle size of trimethoprim≤20μm.

[0036] Preparation steps:

[0037] (1) Add EDTA-Na 2 After dissolving with a small amount of water, add 12ml of propylene glycol, dilute to 50ml with water, add sulfachlorpyrazine sodium, stir to dissolve.

[0038] (2) Mix sorbic acid and remaining propylene glycol, add sodium hydroxyethyl cellulose, and infiltrate evenly;

[0039] (3) Mix the solutions obtained in (1) and (2), add Tween-80 at the same time, and stir until it becomes clear.

[0040] (4) Add methotrexate to the solution obtained in (3), place it in a colloid mill and grind for 15-30 minutes until the solution is well suspended, then add pure water to make it 100ml. ...

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Abstract

The invention belongs to the technical field of veterinary drugs and discloses a preparation method of a compound sulfachloropyrazine sodium suspension. The suspension comprises sulfachloropyrazine sodium, sodium hydroxyethyl cellulose, tween-80, EDTA-Na2, a synergist, a preservative and a solubilizer. The preparation method comprises the steps of mixing 1 / 3 volume dose of solubilizer with the preservative, and then adding the sodium hydroxyethyl cellulose; adding the rest solubilizer into the EDTA-Na2, adding water for dilution, and finally adding the sulfachloropyrazine sodium and stirring for dissolution; mixing the solutions, adding the tween-80 and suspending with the synergist to obtain the compound sulfachloropyrazine sodium suspension. According to the method disclosed by the invention, by selecting scientific suspending aid, solubilizer, preservative and metal complexing agent, the medicine of the dosage form does not generate accumulative precipitate after long-time standing, so that the medicine is uniformly distributed in an aqueous phase and can be synchronously absorbed in an administration process, thus the disease treatment requirements are met, and the treatment effect is sufficiently realized.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and relates to a preparation method of compound sulfachlorpyrazine sodium suspension. Background technique [0002] Sulfachlorpyrazine sodium is a common sulfonamide anticoccidial drug, which is widely used in the production of coccidiosis treatment. Due to long-term use, coccidia have developed a certain drug resistance to sulfachlorpyrazine sodium, making the drug efficacy be affected to a certain extent. In the course of treatment, it is generally used together with the synergist trimethoprim, which not only improves the anticoccidial effect of sulfachlorpyrazine sodium, but also has a typical synergistic effect. [0003] In the treatment of coccidiosis, it is generally administered orally, but there is a difference in the water solubility of the two drugs, sulfachlorpyrazine sodium and metmethoxine, which makes it impossible to uniformly administer the drug, and the absorption r...

Claims

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Application Information

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IPC IPC(8): A61K31/635A61K31/505A61K9/10A61P33/02
Inventor 郝智慧张浩刘明强
Owner QINGDAO BOITE BIOPHARM
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