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Effervescence tablet of miconazole nitrate for vagina and preparation technique

A technology of miconazole nitrate and effervescent tablets, which can be used in medical preparations containing active ingredients, drug delivery, and pill delivery, etc., and can solve problems such as not being able to satisfy patients well

Inactive Publication Date: 2006-02-01
福寿堂制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent No. 01127644.4 mentions a kind of miconazole nitrate ointment, but this product is mainly for external use on the skin, not a vaginal drug, and cannot well meet the needs of patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] ① Weigh 10.0g of povidone K30, add absolute ethanol to 100ml, stir continuously to dissolve, then add 805.0g of polysorbate into it, stir well, use as adhesive, and set aside.

[0026] ②Weigh 200.0g of miconazole nitrate and 155.0g of tartaric acid, mix them, crush them, pass through a 80-mesh sieve, use the above-mentioned adhesive to make a soft material, pass through a 14-mesh sieve to make wet granules, and dry at 60°C-70°C , granulated with a 12-mesh sieve, and set aside.

[0027] ③Weigh 170.0g of sodium bicarbonate and 128.0g of microcrystalline cellulose, mix them, pulverize them, pass through an 80-mesh sieve, use the above-mentioned binder to make a soft material, pass through a 14-mesh sieve to make wet granules, and store them at 60°C-70°C Dry at ℃, granulate with a 12-mesh sieve, and set aside.

[0028] ④Mix the granules prepared in ② and ③, add 14.0g of magnesium stearate and 28.0g of sodium carboxymethyl starch, mix well, after the granules pass the conte...

Embodiment 2

[0030] Miconazole nitrate 200g, tartaric acid 150g, sodium bicarbonate 165g, microcrystalline cellulose 120g, polysorbate 804g, sodium carboxymethyl starch 25g, magnesium stearate 12g, other steps are with embodiment 1.

Embodiment 3

[0032] 200 parts of miconazole nitrate, tartaric acid 160g, sodium bicarbonate 175g, microcrystalline cellulose 130g, polysorbate 806g, sodium carboxymethyl starch 30g, magnesium stearate 16g, other steps are with embodiment 1.

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Abstract

A vaginal effervescent tablet of miconazole nitrate is proportionally prepared from miconazole nitrate, tartaric acid, sodium dicarbonate, microcrystalline cellulose, polysorbitate, carboxymethyl starch sodium and magnesium stearate.

Description

technical field [0001] The invention relates to miconazole nitrate vaginal effervescent tablet and a preparation process thereof. Background technique [0002] Miconazole nitrate is a synthetic 1-phenylethyl imidazole derivative, and its active ingredient is miconazole. This drug can interfere with the activity of cytochrome P450, inhibit the biosynthesis of ergosterol in the fungal cell membrane, change the permeability of the membrane, and cause the leakage of intracellular substances; it can also inhibit the biosynthesis and oxidase of fungal triacylglycerol and phospholipid And the activity of peroxidase, causing the accumulation of hydrogen peroxide in cells, resulting in cell submicrostructural degeneration and cell necrosis. The drug can also inhibit the process of Candida albicans transforming from spores to invasive hyphae. This drug is a broad-spectrum antifungal drug, which has inhibitory and bactericidal effects on dermatophytes, candida, yeast and cryptococcus...

Claims

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Application Information

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IPC IPC(8): A61K31/4174A61K9/20A61K9/46A61P15/02
Inventor 胡起玮
Owner 福寿堂制药有限公司
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