66results about How to "Promote absorption in the body" patented technology

The invention belongs to the technical field of a macromolecular function material, and particularly relates to a novel narrow-distributed / high-purity dobby polyethylene glycol formed by using polyhydric alcohol glyceryl ether as initiator to polymerize ethylene oxide, and its active derivative. The dobby polyethylene glycol has a structure of a general formula II, wherein B is polyhydric alcohol group and n is integer from 3 to 22; PEG is the same or different -(OCH2CH2)m-, the mean value of m is integer ranged from 3 to 250; number-average molecular weight of the dobby polyethylene glycol is 1500-80000. The invention further provides gel formed by active derivative of the narrow-distributed / high-purity dobby polyethylene glycol, a drug composition formed by the gel and the drug molecule and its application in drug preparation.

The present technology relates to a cannabidiol nano powder, a composition containing the cannabidiol nano powder, a solution of the composition in an aqueous solvent, and application of the composition. The invention also relates to a preparation method of the cannabidiol nano powder. According to the composition containing cannabidiol nanocrystals, the dissolution rate of cannabidiol is improved, and the bioavailability of the cannabidiol in vivo is remarkably improved.

A compound represented by general formula (I) [wherein --- represents a single bond or a double bond; L represents -NH- or the like; X1 represents N or C, provided that in the case where X1 is N, X2 represents C-R and in the case where X1 is C, X2 represents N-R1 or the like; Y's may be either the same or different and represent CH2 or the like; A represents a non-natural sugar residue represented by general formula (II) [wherein m represents 0 to 1; --- represents a single bond or a double bond; X represents 0 or the like; and R3 to R9 may be either the same or different and represent a hydroxyl group or the like]; and B represents a group represented by general formula (III) [wherein n and k represent 0 to 5; --- represents a single bond or a double bond; Z1 to Z16 may be either the same or different and represent CH or the like; R10 and R11 may be either the same or different and represent a lower alkoxy group having 1 to 5 carbon atoms or the like; and R15 represents a hydrogen atom or the like]], a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof or a solvate thereof. Because of having an excellent CNT2 inhibitory activity and showing a high in vivo stability and stable physicochemical properties, the aforesaid compound is useful as a remedy for hyperuricemia.

The invention discloses a self-microemulsion, in particular to a curcumin self-microemulsion and a preparation method thereof. The curcumin self-microemulsion is characterized by the following components by weight percent: 0.05%-10% of curcumin, 1%-35% of oil phase, 20%-80% of surfactant, and 2%-40% of cosurfactant. The curcumin self-microemulsion and the preparation method thereof has the benefits that: a curcumin self-microemulsion release system increases the solubility of drugs, protects the drugs dissolved in oil drops, and improves the stability in a body; and the surfactant can change the flowability of cell membranes, improve membrane permeability of the drugs, enhance the absorption of the drugs in the body and increase the relative bioavailability of oral drugs.

The present invention relates to a high-effective oral silibinin (SLB) slow-released preparation. Its composition includes (by mass component portion) 1 portion of silibinin, 1.5-2.5 portions of polyvidone-K30, 0.23-0.58 portion of hydroxypropyl methyl cellulose 4000cPa.S, 0.46-1.38 portions of low-substituted hydroxypropyl cellulose. Said invention adopts the combination of solid dispersion technique and slow-released hydrophilic gel skeleton technique to raise the dissolubility of silibinin.