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Self-emulsifying eicosapentaenoic acid nutrient composition and application thereof

A nutritional composition and self-emulsifying technology, applied in the directions of drug combinations, plant raw materials, medical preparations containing active ingredients, etc., can solve the problems of irritation, easy recurrence, inconvenience in eating, etc., and achieve increased absorption in the body, significant treatment effect, effect without dependency

Inactive Publication Date: 2017-07-11
SINO NUTRACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The defective of prior art is: at present, the medicine of western medicine treatment arthritis is more, because the mechanism of western medicine to this disease is not fully understood yet, most are based on anti-inflammatory and analgesic, can not play radical effect, and these medicines are taken for a long time and are harmful to human body. The side effects of TCM are very large, and it is easy to relapse after treatment, which brings inestimable physical and psychological harm to the patient; although the treatment method of traditional Chinese medicine can relax the stiff joint muscles, dredge the meridians, reduce swelling and relieve pain, the compatibility of traditional Chinese medicine preparations is complex, It is inconvenient to eat, and some traditional Chinese medicines have toxic side effects and irritating effects; although physical therapy and acupuncture treatment have less adverse reactions, their long-term efficacy is still difficult to be confirmed.

Method used

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  • Self-emulsifying eicosapentaenoic acid nutrient composition and application thereof
  • Self-emulsifying eicosapentaenoic acid nutrient composition and application thereof
  • Self-emulsifying eicosapentaenoic acid nutrient composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Recipe: (weight)

[0023]

[0024] Mix EPA and emulsifier, then add grape seed extract and vitamin K2, stir evenly, and fill soft capsules.

[0025] EPA fish oil from deep sea cod.

Embodiment 2

[0027] Recipe: (weight)

[0028]

[0029] Mix EPA and emulsifier, then add grape seed extract and vitamin K2, stir evenly, and fill hard capsules.

[0030] The EPA is from tuna oil.

Embodiment 3

[0032] 1. Animal experiments

[0033] (1) Animal selection: 40 weaned Wistar rats with a body weight of 80-100 g were selected. Rats were reared in single cages and randomly divided into 4 groups, 10 in each group. Animals were housed in separate cages and acclimatized for at least one week prior to experimentation. The animal laboratory was equipped with automatic temperature (22±1°C) and lighting control (12 hours light / 12 hours dark). The experimental procedures and animal feeding of animals were carried out in accordance with the institutional guidelines of the "Manual for the Care and Use of Laboratory Animals" of the National Institutes of Health.

[0034] (2) Drug administration: all adopt oral administration, and the dose is expressed as administration amount (g) / body weight (kg)

[0035] (3) Acute inflammation model: the anti-inflammatory effect of the composition was studied using the acute inflammation model induced by cross-vegetable gum.

[0036] Rats received...

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PUM

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Abstract

The invention provides a self-emulsifying EPA (eicosapentaenoic acid) nutrient composition and an application thereof. The self-emulsifying EPA nutrient composition comprises, by weight, 30-85% of EPA, 10-70% of grape seed extract, 0.002-0.04% of vitamin K2, and 4-10% of an emulsifier. The self-emulsifying EPA nutrient composition has a substantial arthritis treatment effect, has small toxic and side effects, can be taken for a long term without dependence, also can promote calcium absorption to make bones healthy, and has healthcare effects. The self-emulsifying EPA nutrient composition increases in-vivo absorption, and the addition of a calcium absorption promoting factor-vitamin K2 promotes the healthiness of the bones during therapy.

Description

technical field [0001] The present invention relates to EPA nutritional composition and its application. [0002] technical background [0003] Arthritis is a common chronic disease, which generally refers to inflammatory diseases that occur in human joints and their surrounding tissues. The clinical manifestations are redness, swelling, heat, pain, dysfunction and joint deformity of joints. The two most common are osteoarthritis and rheumatoid arthritis. At present, it is estimated that there are more than 100 million arthritis patients in my country, and the number is still increasing. According to statistics, half of the people over the age of 50 in my country suffer from osteoarthritis, 90% of women and 80% of men over the age of 65 suffer from osteoarthritis; the prevalence rate of rheumatoid arthritis in my country is 0.34-0.36% . According to reports, the life expectancy of people with severe rheumatoid arthritis is shortened by about 10-15 years. Arthritis has a gre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/87A61K31/202A61P19/02A61K31/122
Inventor 顾茂健周林苏健梅
Owner SINO NUTRACEUTICAL CO LTD
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