94 results about "Phenoxy acetic acid" patented technology

The invention relates to a method for synthesizing a phenoxyacetic acid derivative. The method comprises the steps of mixing a salt compound of phenol or methyl phenol and a salt compound of chloroacetic acid, putting the mixture in a solvent to carry out a heating reaction, acidifying with an inorganic acid to obtain phenoxyacetic acid, dissolving the phenoxyacetic acid in a solvent, adding a catalyst to the solvent, passing chlorine in the solvent and carrying out a heating chlorination, cooling and crystallizing to obtain a chlorinated phenoxyacetic acid derivative or a methyl phenoxyacetic acid derivative. Compared with a conventional method, the method provided by the invention can recycle the solvent of the reaction system and wastewater for cycle use during the reaction process, can meet self-production balance and realize recycle and reuse of a sealed system, and has a yield higher than 95%, a content larger than 98%, the recycle and reuse utilization rate of the solvent higher than 95% and emission reduction of the waste water in the whole production process higher than 95%.

A process for preparing 2-methyl-4-chloro-sodium phenoxyacetate from O-phenylcresol, chloroacetic acid, sodium hydroxide and chlorine gas includes such steps as neutralizing reaction, etherifying reaction, chlorating reaction and salting reaction. It can be used as herbicide.

The preparation of an intermediate, a process for the preparation thereof and the process of preparing [4-[3,3-Bis-(4-bromo-phenyl)-allyloxy]-2-methyl-phenoxy]-acetic acid using this intermediate are described.

The invention discloses a recovery method of glycolic acid in phenoxy carboxylic acid industrial wastewater. The recovery method comprises the following steps of: extracting the wastewater to remove most of the organic substances in the wastewater, and treating the extracted wastewater in the next step; evaporating and concentrating the wastewater to remove most of the inorganic salt in the wastewater; adjusting the pH value of the desalted wastewater to 1-4, carrying out reduced pressure distillation to remove most of the water in the wastewater, separating out salt from the wastewater in the distillation process, and filtering to remove the salt in the wastewater, thus obtaining more than 70% of henoxy carboxylic acid solution. The recovery method has the advantages of being simple in operation and low in cost, separating out the glycolic acid with high quality from the wastewater, solving the difficulty in treatment of phenoxy carboxylic acid industrial wastewater, being in line with national policy requirements, realizing resource utilization, obtaining good economic benefits, reducing product cost and achieving the clean production requirements.

The invention discloses a phenoxyacetic acid derivative, a preparation process thereof and use thereof as medicaments, and provides a compound shown as formula (I) and a physiologically acceptable salt thereof, wherein the symbols are as defined in the specification. The compound or physiologically acceptable salt thereofhas GPR40 (G-protein-coupled receptor) regulation function, can cause increase in insulin release, and is useful to be used as an insulin secretagogue or medicaments for prevention or treatment of diabetes and the like.

The invention discloses (thiosemicarbazideformyl) phenoxyacetic acid derivatives and application of using the (thiosemicarbazideformyl) phenoxyacetic acid derivatives as tyrosinase inhibitors. The general formula of the (thiosemicarbazideformyl) phenoxyacetic acid derivatives is shown as formula I, wherein R<1> is selected from hydrogen or alkoxy with one to six carbon; and R<2> is selected from groups shown as the accompanying drawing and the R<3> is selected from linear alkyl with one to six carbon.

The invention discloses a crop growth regulator composition. Effective components of the crop growth regulator composition are acetyl-thiazolidine-4-carboxylic acid and auxin substances, wherein the auxin substance is any one of indoleacetic acid, naphthylacetic acid, indolebutyric acid, p-chlorophenoxyacetic acid and p-iodophenoxyacetic acid; the dosage forms of the crop growth regulator composition are soluble powder, soluble granules, water aqua and ultra-low volume spray. The composition is diluted to 1-2000 mg / kg with water, dipping treatment is conducted in a photinia fraseri seedling stage, fruit dipping treatment is conducted in a kiwifruit young fruit expanding stage, spraying treatment is conducted in a soybean initial flowering stage, and the effects of promoting root system development, promoting fruit enlarging or grain plumpness and increasing the yield are achieved; and moreover, the regulator composition disclosed by the invention is a regulator compound consisting of acetyl-thiazolidine-4-carboxylic acid and auxin substances, so that the number and the root length of crop root systems are increased, the fruit enlarging speed and the fruit weight can be increased, and the regulator composition has the characteristics of the quick effect and the strong activity.

The invention discloses a method for producing 2,4-dichlorphenoxyacetic acid. The method comprises the following steps of: etherifying, dehydrogenating and oxidizing phenol and epoxy ethane in the presence of an oxidation catalyst to generate phenoxy acetic acid; dissolving the phenoxy acetic acid in a mixed solvent; making the solution react with chlorine in the presence of a chlorination catalyst; and cooling, crystallizing, filtering and drying to obtain the 2,4-dichlorphenoxyacetic acid. The method has the advantages of easiness for operation, avoidance of dioxin which is an extremely toxic substance and chlorinated phenol which is a smelly substance during production, high environmental friendliness, small amount of waste water and small treating amount of three wastes; the product has high yield and good quality; and the content of active ingredients is over 98.6 percent.

The invention discloses a chlorination method for phenoxyacetic acid, which mainly solves the problems of high cost, low yield, poor selectivity and environment pollution of the existing phenoxyacetic acid prepared with the existing chlorination method for phenoxyacetic acid. The chlorination method comprises the following operation steps of: 1. preparing a phenoxyacetic acid solution; 2. carrying out electrolysis; and 3. purifying. The chlorination method has the advantage of simple step, is convenient to operate, is operated at the room temperature and does not need any catalyst so as to lower preparation cost; in addition, the chlorination method has good selectivity, and methyl 4-chlorophenoxyacetic acid, 2,4-dichlorophenoxy aceticaci and 2,4,6-trichlorophenoxyacetic acid can be prepared respectively under different electrolysis conditions with the respective yield of over 90%; and in the chlorination method, chlorine does not serve as a raw material, thereby causing small environment pollution. The chlorination method is mainly used for preparing methyl 4-chlorophenoxyacetic acid, 2,4-dichlorophenoxy aceticaci and 2,4,6-trichlorophenoxyacetic acid.

The present invention provides a cotton topping agent, which comprises, by weight, 0.8-2 parts of paichongding, 0.8-2 parts of hydroxypropylmethylcellulose, 3-6 parts of beta-methylnaphthalene, 5-10 parts of fosamine-ammonium, 10-15 parts of isonicotinic acid, 10-15 parts of iodophenoxyacetic acid, 15-20 parts of p-chlorotoluene, and 15-20 parts of sodium disec-octyl maleate sulfonate. According to the present invention, the cotton topping agent is organically dissolved, such that the cotton top can be killed, the cotton length can be effectively controlled, the ideal plant type can be shaped,the flower and the bud can be retained, the photosynthesis of cotton can be enhanced, the cotton boll can be increased, the diseases can be prevented and controlled, the boll opening early maturity can be achieved in advance by more than seven days, the micronaire value of cotton is not affected, and the purposes of high yield and stable production are achieved.

The invention provides a 2,4-dichlorophenoxyacetic acid preparation method including the following steps: A) providing phenoxyacetic acid; B) mixing hydrochloric acid, an oxidizing agent and the phenoxyacetic acid of the step A), carrying out a chlorination reaction in the presence of a chlorination catalyst, to obtain 2,4-dichlorophenoxyacetic acid, wherein the molar ratio of the phenoxyacetic acid to the hydrochloric acid to the oxidizing agent is 1 to (2-200) to (2-200), and the molar ratio of the hydrochloric acid to the oxidizing agent is 1 to (0.1-10). The 2,4-dichlorophenoxyacetic acid preparation method provided by the invention only needs one-step chlorination reaction, and then the 2,4-dichlorophenoxyacetic acid can be obtained; while the purity and yield of the 2,4-dichlorophenoxyacetic acid are ensured, the production process of the 2,4-dichlorophenoxyacetic acid is simplified. Moreover, the preparation method provided by the invention has no 'three wastes' emissions and achieves greenization of synthesis of the product.

The invention provides new phenoxy carboxylic acid derivatives represented by the formula A-COX-L-ONO2. The structure is characterized by linking nitrate and carboxyl in phenoxy carboxylic acid molecule through coupling bridge structure. In the formula, A is the role for the phenoxy residues of phenoxy acetic acid compounds with lipid-lowering effect, X represents O or NH, and L is for C2-C6 alkyl and substituted alkyl, C3-C6 naphthene, hydroxyl-containing amino acid residues such as serine and threonine residues, or dialkyl substituted piperazine. The invention also provides the drug combinations using the new phenoxy carboxylic acid derivatives as active components and their applications in liver treatment and lipid-lowering.

Novel compounds having excellent PPAR α / γ agonist effects and having desirable properties for medicaments are provided. Peroxisome proliferator-activated receptor α / γ agonists of the general formula (I): (wherein Q is an optionally-substituted benzene or pyridine ring; R1 and R2 each are an optionally-substituted phenyl group or 5- or 6-membered aromatic heterocyclic group; X Y, and Z are independently C, O, S or N; R3 to R9 each are a hydrogen atom, a lower alkyl group, etc.; n is an integer of 0 to 3).

The invention discloses a method for producing 2-methyl-4-MCPA. In the presence of catalyst dimethylamino pyridine and dimethyl formamide, 2-methyl -phenoxy acetic acid introduces chlorine into sodium hydroxide aqueous solution to react so as to obtain the finished product of the 2-methyl-4-MCPA. The invention has the advantages of simple operation and good environment protection property, the yield of the 2-methyl-4-MCPA is improved to be above 95%, and the content of effective ingredients is above 97%.

The present invention relates to a method for producing an oligonucleic acid derivative characterized by using a phenoxyacetic acid derivative anhydride as an acylating agent and a pyridine derivative as the acylation reaction activator, in a capping step for protecting the 5′-hydroxyl group of a ribose of an oligonucleic acid derivative.

The invention relates to a paddy field herbicidal composition based on non-transgenic imidazolinone herbicide-resistant rice varieties, comprising active ingredients a, b and c; wherein a is selected from imazethapyr, imazamox, imazethapyr, imazamox A kind of in acid, imidazolinic acid, imazapyr, imazamox, imazamox methyl, b and c are respectively selected from aryloxyphenoxypropionic acids, sulfonylureas, sulfonamides, triazoles Pyrimidine sulfonamides, amides, pyrimidinesalicylic acids, pyridyloxyacetic acids, arylpicolinates, quinoline carboxylic acids, phenoxyacetic acids, triketones, pyrazolopyridine rings, oxadi One of azole nitrogen-containing heterocycles, fluorophenyl ethers, triazolinones, organic heterocycles, dithiophosphoric acid esters, and benzonitrile, the categories of b and c can be the same but the specific compounds are different, The combination of a, b and c in a certain proportion has a synergistic effect on the target weeds, and is suitable for preventing annual weeds in paddy fields of non-transgenic rice varieties resistant to imidazolinone herbicides.

The invention disclose a chemical structure of the 4-(2-Benzothiazolyliminomethyl)phenoxyacetic acid (1) and the copper complex (2) thereof, which is described as chart. The invention also discloses the preparing method of above two composition. The disclosed two composition has a strong antibiosis and mildewproof function, a simple and mature art, a low cost and little waste output which can be used for antibiosis and mildewproof agent in the paper industry.

The invention provides a degrading strain for dimethyltetrachloro (MCPA) of a phenoxyacetic acid herbicide and a microbial agent produced by the degrading strain, wherein the adopted strain is a gramstaining reaction negative strain DCP-6d, the strain is identified as Pigmentiphaga sp., the strain is deposited in the China Center for Type Culture Collection on December 23, 2019, and the preservation number of the strain is CCTCC M 20191085. The degrading strain DCP-6d for the MCPA of the phenoxyacetic acid herbicide can be applied to degradation of the MCPA and 2,4-dichlorphenoxyacetic acid (2,4-D), and is preferentially applied to degradation of the MCPA in soil; and a degrading microbial agent product is directly applied so that the residual quantity of the MCPA in the soil can be decreased by 90% or above, and the pollution problem of the MCPA in the soil is solved.

The present invention discloses a watermelon yield increasing chemical, which is confected by the raw materials of phenoxy acetic acid, brassin and potassium dichromate according to the following weight percentage: 30.97 to 41.95 percent of phenoxy acetic acid, 0.03 to 0.05 percent of brassin and 69 to 58 percent of potassium dichromate. The liquid of the confected preparation is continuously sprayed in various growth phases of watermelon, and the adversity and drought resistance of watermelon can be improved, the nutrient absorption of watermelon can be improved, the capillary root growth can be accommodated and the speed rate of photosynthesis can be increased, so as to ensure developed watermelon root system with deep root, thick stalk and luxuriant leaves, further the watermelon growth is promoted. At the same time, the present invention has obvious curing effect on continuous cropping of the watermelon crop as well as blast and bacterial blight due to the infection of epiphyte and bacteria in the seedling period. The most unique feature is that the watermelon seedlings can grow two batches of watermelons, namely, after the first batch grows up for 35 days, the seedling can continue to bear fruits and the second batch are ripe after 20 days.

The invention discloses a dimethylamine salt of 2-methyl-4-chlorophenoxyacetic acid. The specific process steps are as follows: 1. adding chloroacetic acid to a reaction kettle, and dripping caustic soda solution to generate sodium chloroacetate; Phenol is added to another reactor, and caustic soda solution is added dropwise to generate sodium o-cresol; 3, the sodium chloroacetate of the previous kettle is added dropwise to the sodium o-cresol reactor of the next kettle to generate sodium 2-methylphenoxyacetate; 4. Transfer the above reaction materials into a chlorination reaction kettle, add hydrochloric acid to generate 2-methylphenoxyacetic acid crystals, add a mixed solvent of xylene and dichloroethane to dissolve the crystals into a solution, and carry out chlorination in the chlorination reaction kettle Reaction, generate 2-methyl-4-chlorophenoxyacetic acid, then transfer to the crystallization tank for crystallization, then put it into a centrifuge for centrifugation, and dry it into crystals after centrifugation; 4 Chlorine, dimethylamine aqueous solution and water are respectively added in the salt-forming reactor to generate the product 2-methyl-4-chlorophenoxyacetic acid dimethylamine salt. The preparation process has few reaction steps, safe process, high efficiency, short cycle and low cost.

The invention relates to a medicament for treating hyperlipemia and atherosclerosis. The medicament contains a lipid-regulating active ingredient A and a lipid-regulating active ingredient B, wherein the lipid-regulating active ingredient A is one or more of nicotinic acid, clofibrate, phenoxy acetic acid and HMG-CoA reductase inhibitor, and the lipid-regulating active ingredient B is one kind or more kinds in long-chain fatty alcohol. The invention also relates to the application of the medicament for treating hyperlipemia or treating atherosclerosis. The medicament greatly reduces the dosage of statins with the curative effect not lower than that of the statins which is singly used, thereby reducing the side effect of the statins, reducing the drug cost and saving the drug expense for the patients.

The invention provides a water-soluble fertilizer containing amino acid. The water-soluble fertilizer is prepared from the following components of marine algal glycoprotein, complex amino acid, brassin, 4-ethyl iodophenoxyacetate, a plant growth regulator, medium element composition and mannitol calcium. The water-soluble fertilizer containing the amino acid has the advantages that the output capacity is increased, the yield increase rate is 20%, and the color turning rate of fruit is 98.1%. The invention also provides a preparation technology of the water-soluble fertilizer containing the amino acid. The preparation technology comprises the following steps of soaking by alcohol, primary activating, secondary activating, fermenting and mixing. The prepared water-soluble fertilizer containing the amino acid has the advantages that the growth of roots can be strongly promoted, and the damaged root is restored; after the water-soluble fertilizer is applied to the crop, the anti-freezing,anti-drought and anti-disease abilities are obviously improved, and the nematodes, whiteflies and aphids can be repelled; the effects of promoting the growth of crop, promoting swelling of fruit and advancing selling on market are realized, and the output is increased by 20%; the soil can be regulated, the air ventilating property of the soil is improved, and the effects of maintaining water and fertilizer, immobilizing nitrogen, decomposing phosphorus and decomposing potassium are realized.

The invention relates to a plant selenium-rich germanium-rich strontium-rich nutrition supplement as well as a preparation method and application thereof. The plant selenium-rich and germanium-rich nutrient supplement is a liquid preparation mainly containing the following components: compound amino acid chelated selenium, sodium octaborate tetrahydrate, organic germanium-132, strontium chloride,glycine betaine, glycine betaine Cab, ammonium heptamolybdate, sodium 4-iodophenoxyacetate and water. The nutrition supplement can significantly improve the ability of rice, rape, tea, wheat and othercrops to absorb and convert selenium element, germanium element and strontium element, significantly improve the selenium content, germanium content and strontium content of the crops, promote earlymaturing and high yield of the crops, promote income increase of farmers, and serve people's health.

The invention discloses a 2,4-dichlorphenoxyacetic acid preparation method which comprises the following special steps: adding chloroacetic acid into a sodium hydroxide solution, stirring, adding into phenol, and regulating the PH value to 11 with sodium bicarbonate; then heating for 40 minutes at 100 DEG C; adding into hydrochloric acid to regulate the PH value to 4; finally cooling in an ice-water bath, and washing and drying the obtained solid to obtain phenoxyacetic acid; adding into the phenoxyacetic acid into an acetic acid and water mixed solution, adding into an Ni-Al-Mg composite oxide, stirring and mixing, wherein the mass of the Ni-Al-Mg composite oxide is 0.05% of that of phenoxyacetic acid; then introducing chlorine to carry out chlorination; reacting for 20-40 minutes, and finishing the chlorination; then cooling the reaction product, and filtering to obtain a solid; at last, drying the solid to obtain the 2,4-dichlorphenoxyacetic acid. The product prepared by the method disclosed by the invention is high in quality, yield and purity; the preparation process is simple, convenient and stable, the industrial cost is low, and the environment is protected.

Compounds having the formulawherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of phenoxy-acetic acids and analogs capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.

Compounds having the formulawherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of phenoxy-acetic acids and analogs capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.

The invention discloses an anti-poison biological agent for plant grafting propagation and a preparation method thereof. The anti-poison biological agent comprises distilled water, indolebutyric acid,4-iodophenoxyacetic acid, indolepropionic acid, naphthylacetic acid and alcohol. According to the anti-poison biological agent for plant grafting propagation, indolebutyric acid is added to induce formation of root plasmas and promote cell differentiation and division, so that a callus surface is thickened quickly, and 4-iodobenzoxyacetic acid and naphthylacetic acid are matched to enable a cambium to inhibit loss of trace elements and reduce poison phenomena caused by lack of trace elements; the plant grafting growth rate is increased, toxic and harmful lesions of plants are effectively avoided, the yield is increased, and the use effect is good.

The invention relates to a method for synthesizing phenoxyacetic acid derivatives. The salt compound of phenol or methylphenol and the salt compound of chloroacetic acid are mixed and placed in a solvent for heating reaction, and then acidified with an inorganic acid to obtain phenoxyacetic acid. Then dissolve it in a solvent and add a catalyst therein, then pass chlorine gas into it and carry out heating and chlorination reaction, and obtain chlorophenoxyacetic acid (or methylphenoxyacetic acid) derivatives after cooling and crystallization. Compared with the prior art, in the reaction process, the present invention recovers and recycles the solvent and waste water of the reaction system, satisfies its own production balance, and can realize the recycling of the closed system, with a yield greater than 95% and a content greater than 98% , The utilization rate of solvent recycling is greater than 95%, and the waste water discharge in the whole production process is reduced by more than 95%.

The invention discloses an application method of a chitosan / glucan-containing moss sporophyte suspension to bare land greening. The application method comprises the following steps of collecting mossspores, and adding a hydrogen peroxide solution into the spores to obtain a mixed solution of disinfected spores and hydrogen peroxide; inoculating the mixed solution of the disinfected spores and thehydrogen peroxide into a spore germination induction culture medium for spore germination induction culture, adding into a solid subculture multiplication culture medium for subculture multiplicationculture after culture, mixing with a liquid culture medium after culture, and carrying out shake culture to obtain a dark green suspension; adding chitosan, glucan, ferric ammonium citrate, phenoxyacetic acid, zinc sulfate and potassium nitrate into the dark green suspension to obtain the moss sporophyte suspension; uniformly smearing a moss adhesive on bare land, then uniformly spraying the mosssporophyte suspension on the surface of the moss adhesive, using a sunshade net for covering, and carrying out spray irrigation in time. The moss sporophyte suspension is used for bare land greening,and the greening covering degree is high after growth.