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Medicament and preparation thereof for treating hyperlipemia and atherosclerosis

An atherosclerosis and drug technology, which is applied in the field of medicine to achieve the effects of reducing economic burden, regulating cardiovascular function and reducing dosage

Inactive Publication Date: 2009-09-30
BEIJING SHENKELIANHUA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term use of large doses of statins can also cause cataracts
For patients with hyperlipidemia, they generally take long-term medication, and the price of statins is the most expensive of all lipid-lowering drugs, so it brings a great economic burden to patients

Method used

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  • Medicament and preparation thereof for treating hyperlipemia and atherosclerosis
  • Medicament and preparation thereof for treating hyperlipemia and atherosclerosis
  • Medicament and preparation thereof for treating hyperlipemia and atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0017] Example 1: Capsules

[0018] Drug Composition:

[0019]

[0020] Preparation:

[0021] Weigh hypromellose and dissolve in purified water, add appropriate amount of ethanol, dilute to 2% hypromellose 30% ethanol solution, and set aside; starch, croscarmellose sodium, and sodium bicarbonate are respectively passed through 100 After the mesh sieve, take the prescription quantity for subsequent use; after taking pravastatin and beeswax through a 120 mesh sieve, take the prescription quantity, mix with the above-mentioned auxiliary materials, and use 2% hypromellose 30% ethanol solution to make a soft material, Granulate with a 20-mesh sieve, dry at 60°C, add magnesium stearate after granulation, mix well and fill capsules.

example 2

[0022] Example 2: Tablet

[0023] Drug Composition:

[0024]

[0025] Preparation:

[0026] Weigh hypromellose and dissolve in purified water, add an appropriate amount of ethanol, dilute to 50% ethanol solution of 2% PVC, and set aside; pass lactose and microcrystalline cellulose through a 100 mesh sieve respectively, weigh the prescription amount for set aside; Weigh the prescribed amount of simvastatin and beeswax through a 200-mesh sieve, mix with the above-mentioned auxiliary materials, make soft material with 50% ethanol solution of 2% PVC, dry after granulation, add the prescribed amount of magnesium stearate, mix Evenly, choose a ф6mm shallow concave die, adjust the pressure, and press the tablet.

Embodiment 3

[0027] Embodiment 3 Pharmacodynamic study

[0028] 1. Experiment preparation

[0029] 1.1 Basic feed formula (%) flour 53, rice flour 1918, corn flour 718, wheat bran 310, yeast 415, casein 110, whole milk powder 415, soybean flour 310, bone meal 112, cod liver oil 112, salt 110.

[0030] 1.2 High-fat feed formula (%) Basic feed 79, cholesterol 1, egg yolk powder 10, lard 10.

[0031] 1.3 Experimental drug: meswax was purchased from Guangzhou Baiyunshan Pharmaceutical Factory, the main components are octacosanol and triacontanol, the contents are 65% and 15% respectively.

[0032] 2. Experimental animal grouping and experimental process

[0033] Select 90 SD male rats, weighing 200-230 g, to study the effect of the compound pharmaceutical preparation for treating hyperlipidemia and atherosclerosis according to the present invention on blood lipid regulation. Animals are divided into 9 groups at random, wherein 6 groups take respectively low, middle and high dose groups (equ...

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PUM

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Abstract

The invention relates to a medicament for treating hyperlipemia and atherosclerosis. The medicament contains a lipid-regulating active ingredient A and a lipid-regulating active ingredient B, wherein the lipid-regulating active ingredient A is one or more of nicotinic acid, clofibrate, phenoxy acetic acid and HMG-CoA reductase inhibitor, and the lipid-regulating active ingredient B is one kind or more kinds in long-chain fatty alcohol. The invention also relates to the application of the medicament for treating hyperlipemia or treating atherosclerosis. The medicament greatly reduces the dosage of statins with the curative effect not lower than that of the statins which is singly used, thereby reducing the side effect of the statins, reducing the drug cost and saving the drug expense for the patients.

Description

technical field [0001] The invention relates to a compound medicinal preparation and its application, in particular to a compound medicinal preparation for treating hyperlipidemia and atherosclerosis and its application, and belongs to the field of medicine. Background technique [0002] Hyperlipidemia is the main cause of atherosclerosis. At present, the commonly used lipid-lowering drugs can treat hyperlipidemia and produce anti-arteriosclerosis effects by adjusting the disorder of plasma lipids or lipoproteins. The most new and effective drug is 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors, ie statins. There are no serious adverse reactions when statins are used in a short-term at a general dose, and a few show mild gastrointestinal reactions, headaches or rashes; however, long-term use (more than 4 weeks) often causes liver damage, so patients cannot tolerate them. After taking it for 4 weeks, the drug must be suspended to facilitate the recovery of li...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/366A61K31/22A61K9/16A61K9/20A61K9/48A61P3/06A61P9/10A61K31/045
Inventor 申静李泳周文艳
Owner BEIJING SHENKELIANHUA TECH
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